Annual Reports in Medicinal Chemistry

Häftad, Engelska, 2010

Del 45 i serien Annual Reports in Medicinal Chemistry

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Beskrivning

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Covers findings related to cardiovascular, inflammation, and pulmonary diseases
Examines issues in oncology, from mTor inhibitors to drug targets
Incorporates up-to-date information on drug design and discovery, including delivery to market

Produktinformation

Utgivningsdatum:2010-11-25
Mått:152 x 229 x undefined mm
Vikt:860 g
Format:Häftad
Språk:Engelska
Serie:Annual Reports in Medicinal Chemistry
Antal sidor:648
Förlag:Elsevier Science
ISBN:9780123809025

Utforska kategorier

Farmakologi inom Medicin

Innehållsförteckning

Section I: Central Nervous System Diseases – ROBICHAUD Voltage-Gated Calcium Channel Antagonists for the Central Nervous SystemJames C. Barrow and Joseph L. DuffyRecent Developments in Glycine Transporter-1 InhibitorsChristopher L. Cioffi, Shuang Liu and Mark A.WolfModulators of Transient Receptor Potential Ion ChannelsRajagopal Bakthavatchalam and S. David KimballDefining Neuropharmacokinetic Parameters in CNS Drug Discovery to Determine Cross-species Pharmacologic Exposure-Response RelationshipsChristopher L. ShafferSection II: Cardiovascular and Metabolic Diseases - STAMFORDHigh Affinity Niacin Receptor GPR109A AgonistsHong C. Shen and Steven L. CollettiRecent Advances in Acetyl CoA Carboxylase (ACC) InhibitorsMatthew P. Bourbeau, John G. Allen, and Wei GuEnzymatic Targets in the Triglyceride Synthesis PathwayDmitry O. Koltun and Jeff ZablockiInhibitors of HIF Prolyl HydroxylasesMichael H. Rabinowitz, Terrance D. Barrett, Mark D. Rosen, Hariharan VenkatesanSection III: Inflammation / Pulmonary / GI - BARRISH/WeinsteinOpioid Receptor Antagonists for Gastrointestinal DysfunctionR. William Hipkin and Roland E. DolleCFTR Modulators for the Treatment of Cystic FibrosisSabine Hadida, Frederick Van Goor and Peter D. J. GrootenhuisTargeting B-cells in inflammatory diseaseKevin S. CurrieModulators of Toll-Like Receptor (TLR) SignalingMark Spyvee, Lynn Hawkins, and Sally IshizakaSection IV: Oncology - McAlpineJanus Kinase 2 (JAK2) inhibitors for the treatment of myeloproliferative neoplasm (MPN)Ashok V. Purandare, Matthew V. Lorenzi and Louis J. LombardoDevelopment of poly(ADP-ribose)polymerase (PARP) inhibitors in oncologyPhilip JonesEpigenetic Targets and Cancer Drug DiscoveryPatrick M. Woster, Ph.DSection V: Infectious Diseases - PrimeauHIV-1 Integrase Strand Transfer InhibitorsBrian A. JohnsRecent Advances in Drug Discovery for Neglected Tropical Diseases Caused by Infective Kinetoplastid ParasitesRobert T. Jacobs and Charles DingRecent Advances in the Inhibition of Bacterial Fatty Acid BiosynthesisVincent GeruszSection VI: Topics in Biology - LOWEBack to the Plaque: Emerging Studies That Re-Focus Attention on the Neuritic Plaque in Alzheimer’s DiseaseDr. Robert B. NelsonTargeting Methyl LysineStephen V. Frye, Tom Heightman and Jian JinChemical Proteomic Technologies for Drug Target IdentificationKieran F. Geoghegan and Douglas S. JohnsonNIH Translational Programs for Assisting Pre-Clinical Drug Discovery and DevelopmentRaj N. MisraSection VII: Topics in Drug Design and Discovery - DESAIRole of Physicochemical Properties and Lipophilic Ligand Efficiency (LipE or LLE) in addressing Drug Safety RisksMartin P. Edwards and David A. PriceReducing the Risk of Drug Attrition Associated with Physicochemical PropertiesPaul D. Leeson and James R. EmpfieldCompound Collection Enhancement and Paradigms for High Throughput Screening - an UpdateStevan W Djuric, Irini Akritopoulou-Zanze, Philip B Cox and Scott GalasinskiThe Role of Fluorine in the Discovery and Optimization of CNS Agents: Modulation of Drug-Like PropertiesKevin J. Hodgetts, Kerry J. Combs, Amy M. Elder and Geraldine C. HarrimanPatents in Drug Discovery: Case Studies, Examples, and Simple Steps Medicinal Chemists Can Take to Protect Hard-Won Intellectual PropertyCharles J. Andres, Jr. and Richard L. TreanorSection VIII: Trends and PerspectivesTo Market, To Market – 2009 Shridhar Hegde and Michelle Schmidt