Structure, Function and Regulation of TOR complexes from Yeasts to Mammals

Part A

Inbunden, Engelska, 2010

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Beskrivning

Cell growth is highly regulated and is controlled by the TOR signaling network. Dysfunction of signaling pathways controlling cell growth results in cells of altered sizes and in turn causes developmental errors and a wide range of pathological conditions. An understanding of the TOR signaling network may lead to novel drugs for the treatment of, for example, cancer, diabetes, inflammation, muscle atrophy, learning disabilities, depression, obesity and aging.

There has been an explosion of knowledge in this area in recent years and this volume provides an in-depth review of our current knowledge of TOR complexes by the leaders in the field.

Contributions from leading authorities
Informs and updates on all the latest developments in the field

Produktinformation

Utgivningsdatum:2010-05-15
Mått:152 x 229 x undefined mm
Vikt:680 g
Format:Inbunden
Språk:Engelska
Serie:The Enzymes
Antal sidor:420
Förlag:Elsevier Science
ISBN:9780123815392

Utforska kategorier

Onkologi inom Medicin

Mer om författaren

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

Innehållsförteckning

Chapter 1: TOR complexes: composition, structure and phosphorylationMike HallChapter 2: Regulation of TOR signaling in mammalsDudley W. Lamming and David SabatiniChapter 3: Rheb G-protein and activation of mTORC1Fuyu TamanoiChapter 4: Regulation of TOR Complex1 by amino acids through small GTPasesJoe Avruch, Xiaomeng Long, Yenshou Lin, Sara Ortiz-Vega, Joseph Rapley, and Noriko OshiroChapter 5: Rag GTPases in TORC1 activation and nutrient signalingLi Li and Kun-Liang Guan Chapter 6: Amino Acid Regulation of hVps34 and mTORC1 signalingPawan Gulati and George ThomasChapter 7: mTORC1 and cell cycle controlChris ProudChapter 8: AGC Kinases in mTOR SignalingEstela Jacinto Chapter 9: TORC1 signaling in budding yeastRobbie Loewith Chapter 10: TORC2 and sphingolipid biosynthesis and signaling: Lessons from budding yeastTed PowersChapter 11: TORC1 signaling in the budding yeast endomembrane system and control of cell-cell adhesion in pathogenic fungiRobert J. Bastidas and Maria Cardenas-CoronaChapter 12: TOR and sexual development in fission yeastYoko Otsubo and Masayuki YamamotoChapter 13: Fission yeast TOR and rapamycinRonit Weisman Chapter 14: Structure of TOR complexes in fission yeastJunko Kanoh and Mitsuhiro YanagidaChapter 15: The TOR complex and signaling pathway in plantsChristophe Robaglia, Bruce Veit and Christian MeyerChapter 16: Dysregulation of TOR Signaling in Tuberous Sclerosis and Lymphangioleiomyomotosis Elizabeth Henske Chapter 17: Chemistry and Pharmacology of Rapamycin and its DerivativesRobert T. Abraham, James J. Gibbons and Edmund I. Graziani