From Molecules to Networks

Dr. Byrne is internationally recognized for his work on the cellular and molecular mechanisms of learning. He has also contributed substantially to graduate and medical education, both locally and nationally. For example, he has authored or edited 15 books including three editions of his textbook From Molecules to Networks: An Introduction to Cellular and Molecular Neuroscience and two editions as Editor-In-Chief of the four-volume Learning and Memory: A Comprehensive Reference, both published by Academic Press. Another contribution is the development of an innovative electronic online textbook Neuroscience Online, which in 2020 received more than two million visits. His YouTube video Introduction to Neuroscience has 898,000 views. Over the past 40years, he has trained 38 postdoctoral fellows and 25 graduate students. His contributions to education and mentoring have been recognized by his receipt of the Award for Education in Neuroscience from the Society for Neuroscience, The University of Texas System Award for Innovation in Health Science Education, The UTHealth President’s Award for Mentoring Women, the UTHealth President’s Scholar Award for Teaching and the UT System Regents’ Outstanding Teaching Award.Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Heidelberger is an accomplished cellular neurophysiologist specializing in mechanisms of neurotransmitter release. She received her doctoral training under the guidance of Gary Matthews and her postdoctoral training under the direction of Nobel Laureate Erwin Neher. Dr. Heidelberger is a former president and executive board member of the Biophysical Society's Subgroup on Exocytosis and Endocytosis and serves on the editorial board of the Journal of Neurophysiology. She has directed and taught graduate-level courses in cellular neurophysiology and membrane biophysics for more than a decade. The William Wheless III Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Waxham’s multi-disciplinary laboratory focuses on the molecular and cellular mechanisms of synaptic function and plasticity. He has developed and directed graduate-level courses in cellular and molecular neurobiology for more than two decades.

"Jack Byrne is unique in neuroscience. He is at once a first class experimentalist, bringing to bear a variety of cellular, molecular and imaging approaches to study the mechanisms of learning and memory storage. Here his work has led to a number of penetrating insights, including the first demonstration of operant conditioning in Aplysia. But in addition, what makes Byrne’s thinking and work so unique, is that it combines these experimental techniques with realistic and creative mathematical modeling to determine the extent to which the observed processes and interactions are sufficient to explain the behavior of systems he studies.This has led to his finding a series of paradigms for enhancing memory storage that are quite remarkable. The Third Edition of From Molecules to Networks is eloquent testimony to this synthesis, the experimental and theoretical and to Jack Byrne’s extraordinary teaching capability, and to his ability to explain science to both students and scientists for which he was recently awarded the National Neuroscience Educational Award." --Eric R. Kandel, MD, Department of Neuroscience, Columbia University, NY, USA"Meshing together the diverse elements of neuroscience, from molecules to man, is one of the great challenges of brain science.  Conveying the integrated story to readers coherently is a major task.  This third edition of the now classic From Molecules to Networks text accomplishes all of this with elegance, even better than the preceding two volumes.  It will be of inestimable value to student and professional alike." --Soloman H. Snyder, MD, Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA"Like the previous two editions, this new edition from Byrne, Heidelberger and Waxham is a joy to read: The volume is beautifully produced, the figures make their points perfectly, and the authors of the various chapters are not only experts in their fields, but also have the knack of explaining things clearly. The two best things about this book, though, are that it is completely up-to-date with an emphasis that matches excitement of the field, and that the book’s structure, from molecules to neural circuits, emphasizes organizational principles rather than the more traditional treatment according to a list of neural systems." --Charles F. Stevens, MD, PhD, Professor, The Salk Institute, San Diego, CA, USa

• SECTION I. CELLULAR AND MOLECULAR1. Cellular Components of Nervous Tissue - Patrick R. Hof, Graham Kidd, Javier DeFelipe, Jean de Vellis, Miguel A. Gama Sosa, Gregory A. Elder and Bruce D. Trapp 2. Subcellular Organization of the Nervous System: Organelles and Their Functions - Scott Brady and Peter Brophy 3. Energy Metabolism in the Brain - Gerald Dienel4. Intracellular Signaling - Howard Schulman5. Regulation of Neuronal Gene Expression and Protein Synthesis - Cristina Alberini and Eric Klann 6. Modeling and Analysis of Intracellular Signaling Pathways - Paul D. Smolen, Douglas A. Baxter and John H. Byrne 7. Pharmacology and Biochemistry of Synaptic Transmission: Classical Transmitters - Ariel Y. Deutch and Robert H. Roth 8. Nonclassic Signaling in the Brain - Ariel Y. Deutch, Andrea Giuffrida and James L. Roberts 9. Connexin- and Pannexin-Based Channels in the Nervous System: Gap Junctions and More - Juan C. Sáez and Bruce Nicholson 10. Neurotransmitter Receptors - M. Neal Waxham11. Molecular Properties of Ion Channels - Jason Tien, Yuh Nung Jan and Lily Yeh Jan SECTION II.  PHYSIOLOGY OF ION CHANNELS, EXCITABLE MEMBRANES AND SYNAPTIC TRANSMISSION12. Membrane Potential and Action Potential - David A. McCormick13. Biophysics of Voltage-Gated Ion Channels - Diane Lipscombe14. Dynamical Properties of Excitable Membranes - Douglas A. Baxter and John H. Byrne15. Release of Neurotransmitters - Robert S. Zucker, Dimitri M. Kullmann and Pascal S. Kaeser 16. Postsynaptic Potentials and Synaptic Integration - John H. Byrne17. Cable Properties and Information Processing in Dendrites - Michael BeierleinSECTION III.  INTEGRATION18. Synaptic Plasticity - Ruth Heidelberger, Harel Shouval, Robert S. Zucker and John H. Byrne 19. Information Processing in Neural Networks - James J. Knierim20. Learning and Memory: Basic Mechanisms - John H. Byrne, Kevin S. LeBar, Joseph LeDoux, Glenn E. Schafe and Richard F. Thompson 21. Molecular Mechanisms of Neurological Disease - Monica Gireud, Natalie Sirisaengtaksin and Andrew J. Bean