Dr. George Patrinos is an Associate Professor at the University of Patras School of Health Sciences (Department of Pharmacy) in Patras, Greece with Adjunct positions in Rotterdam, the Netherlands and Al-Ain, United Arab Emirates. His research interests span the fields of molecular diagnostics, high-throughput mutation screening, the development of online mutation diagnostic tools, and the implementation of genomics into healthcare, particularly for health systems in developing countries. George Patrinos has published more than 170 scientific papers in peer reviewed journals on topics related to genetics, genomic medicine, pharmacogenomics, molecular diagnostics, and social and economic evaluation for genomic medicine. Dr. Patrinos is also the co-author of Economic Evaluation in Genomic Medicine (2015) and co-Editor of Molecular Diagnostics, Second Edition (2009), both published by Elsevier, and serves as Communicating Editor for the journal Human Mutation. Additionally, he is co-organizer of the international meeting series “Golden Helix Symposia” and “Golden Helix Pharmacogenomics Days”. Prof. Dr. Wilhelm Ansorge is a Senior Research Scientist and coordinator of the Biochemical Instrumentation Programme at the European Molecular Biology Laboratory in Heidelberg, Germany. His research interests include the development of the first complete Human Genome microarray, with numerous applications in gene expression studies and high-throughput Molecular Diagnostics.

"...the book is uniform in style. The text is free of jargon and is well written in an easy to understand style. ...This book is a great resource for experienced readers, giving them a wide overview of the most up-to-date methods. It is also a great book for students and medical professionals who want to learn about the molecular tools used in diagnostics. ...a great teaching aid for courses involving molecular biology, genetics and diagnostic techniques." --AUSTRALIAN BIOCHEMIST (April 2006)"...the book will be useful to investigators in the diagnostic laboratory and to scientists generally who want a summary of current methods. ...Inclusion of ethical and safety considerations (as well as a section on patents) is a distinct plus, not often seen. ...this is a well organized and edited contribution." --DOODY'S (October 2005)

• Chapter 1: Molecular Diagnostics: Past, Present, and FutureSection I: Molecular Diagnostic TechnologyChapter 2: Allele-Specific Mutation Detection by PCR-ARMS and PCR-ASOChapter 3: Competitive OligoprimingChapter 4: Oligonucleotide Ligation Assays for the Diagnosis of Inherited DiseasesChapter 5: Enzymatic and Chemical Cleavage Methods to Identify Genetic VariationChapter 6: Mutation Detection by Single Strand Conformation Polymorphism and Heteroduplex AnalysisChapter 7: Capillary ElectrophoresisChapter 8: Temperature and Denaturing Gradient Gel ElectrophoresisChapter 9: Two-Dimensional Gene ScanningChapter 10: Real-Time Polymerase Chain ReactionChapter 11: PyrosequencingChapter 12: Molecular Cytogenetics in Molecular DiagnosticsChapter 13: Detection of Genomic Duplications and DeletionsChapter 14: Analysis of Human Splicing Defects Using Hybrid MinigenesChapter 15: DNA Microarrays and Genetic TestingChapter 16: Human Genome Microarray in Biomedical ApplicationsChapter 17: Use of High Throughput Mass Spectrographic Methods to Identify Disease ProcessesChapter 18: The Application of Proteomics to Disease DiagnosticsSection II: Applications of Molecular Diagnostics and Related IssuesChapter 19: Identification of Genetically Modified OrganismsChapter 20: Pharmacogenetics and Pharmacogenomics: Impact on Drug Discovery and DevelopmentChapter 21: Molecular Diagnostic Applications in Forensic ScienceChapter 22: Molecular Diagnostics and Comparative Genomics in Clinical MicrobiologyChapter 23: Preimplantation Genetic DiagnosisChapter 24: Genetic Monitoring of Laboratory AnimalsChapter 25: The Use of Locus-Specific Databases in Molecular DiagnosticsChapter 26: Safety Analysis in Retroviral Gene Therapy: Identifying Virus Integration Sites in Gene-Modified CellsChapter 27: Automated DNA Hybridization and DetectionChapter 28: The Use of Microelectronic-Based Techniques in Molecular Diagnostic AssaysChapter 29: Miniaturization Technologies for Molecular DiagnosticsChapter 30: Human Gene Patents and Genetic TestingChapter 31: Genetic Counselling and Ethics in Molecular DiagnosticsChapter 32: Genetic Testing and PsychologyChapter 33: Safety in Biomedical and Other LaboratoriesChapter 34: Quality Management in the Laboratory