Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors

Dr. Prashant Kesharwani is assistant professor of Pharmaceutics at Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya University, Sagar, Madhya Pradesh, India. He has more than 12 years of teaching, research, and industrial experience across various countries. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He has more than 350 international publications in well-reputed journals and more than 25 international books (Elsevier). He is a recipient of many research grants from various funding bodies. He is also the recipient of several internationally acclaimed awards, such as “USERN Laureate award”, and “SERB-Ramanujan Fellowship Award”. He has presented many invited talks and oral presentations at prestigious scientific peer-conferences, received international acclaims and awards for research contribution, supervised students/junior researchers and actively participated in outreach and scientific dissemination for the service of the wider community. Dr. Umesh Gupta, currently working as Assistant Professor at Department of Pharmacy, Central University of Rajasthan, India, did his bachelor's, master's and doctorate degree in Pharmaceutical Sciences from Dr. H. S. Gour University, India under the mentorship of Prof. NK Jain. He has recently been awarded for “DAAD Research Stays for Academics and Scientists” at Leibniz-institut fur Polymerforschung Dresden, Germany. He has the past experience of Research Scientist at Ranbaxy Research Laboratories, India and Post-Doctoral Research Associate at South Dakota State University, USA. HE is also recipient of Young Scientist Award by Department of Science and Technology, Government of India as well as Ranbaxy Science Scholar Award 2008 by Ranbaxy Research Laboratories, India. He has been awarded more than 3-4 times the overseas travel award by different funding agencies of Indian government to share and present his research at international platform in countries like Germany, USA and Singapore etc. He has more than ten years of research and academic experience. The area of research is mainly focused on dendrimer mediated drug delivery, solubilization and targeting. His laboratory equally focuses on effective brain delivery through nanotechnological carriers such as polymeric micelles, nanoparticles and dendrimers. He has more than 48 publications and seven book chapters to his credit with total citations of more than 2300 (h index of 23 as per Google Scholar).

• 1. Introduction: An Overview of the Anatomy and Physiology of the Brain2. Angiogenesis in brain tumors3. Physiology of the Blood Brain Barrier (BBB) and mechanisms of Transport across the BBB4. Active Targeting Systems (Ligands) / Receptor overexpressed on brain5. Nanotechnology in Brain Targeting6. Polymeric nanoparticles based drug delivery for brain tumors7. Solid lipid nanoparticles (SLN)based drug delivery for brain tumors8. Liposomes based drug delivery for brain tumors9. Dendrimers based drug delivery for brain tumors10. Micelles based drug delivery for brain tumors11. Nanoemulsions based drug delivery for brain tumors12. Nanogel based drug delivery for brain tumors13. Beyond the blood–brain barrier — facing new challenges14. Towards development of neuro-diagnostic nano-imaging platform15. Future prospects of nanoparticles on brain targeted drug delivery