Advances in Immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

• 1. Chromosome 17q21 Genes ORMDL3 and GSDMB in Asthma and Immune DiseasesSudipta Das, Marina Miller and David H. Broide2. Complement System in Neural Synapse Elimination in Development and DiseaseJessy Presumey, Allison R. Bialas and Michael C. Carroll3. A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive InfectionXing Liu and Judy Lieberman4. Chemokine-Driven CD4+ T Cell Homing: New Concepts and Recent AdvancesCarly E. Gregor, Jade Foeng, Iain Comerford and Shaun R. McColl