Platform Technologies in Drug Discovery and Validation

Robert A. Goodnow, Jr. is currently Vice President, Chemistry Innovation at Pharmaron, Inc in Boston, MA. He completed a Ph.D. in bioorganic chemistry at Columbia University, New York, USA, followed by postdoctoral training at Princeton University, New Jersey, USA. He has worked at Roche and AstraZeneca, focusing on new lead and target discovery as well as implementing chemistry technologies in support of early drug discovery. He is the editor and author of The Handbook of DNA-Encoded Chemistry, which was published in 2014 by Wiley.

• 1. DNA-Encoded Library Technology: A Brief Guide to Its Evolution and Impact on Drug DiscoveryRobert A. Goodnow Jr. and Christopher P. Davie2. The Chemistry of Oligonucleotide DeliveryDavid B. Rozema3. CRISPR–Cas9 for Drug Discovery in OncologySylvie M. Guichard4. Recent Advances of Microfluidics Technologies in the Field of Medicinal ChemistryLászló Ürge, Jesus Alcazar, Lena Huck and György Dormán5. High-Throughput ScreeningMary Jo Wildey, Anders Haunso, Matthew Tudor, Maria Webb and Jonathan H. Connick6. Kinase-Centric Computational Drug DevelopmentAlbert J. Kooistra and Andrea Volkamer7. Free Energy Calculation Guided Virtual Screening of Synthetically Feasible Ligand R-Group and Scaffold Modifications: An Emerging Paradigm for Lead OptimizationRobert Abel and Sathesh Bhat8. Phenotypic ScreeningAlleyn T. Plowright and Lauren Drowley9. Targeted Protein DegradationNello Mainolfi and Tim Rasmusson10. Chemical Biology in Drug DiscoveryM. Paola Castaldi, Andrea Zuhl, Piero Ricchiuto and J. Adam Hendricks11. Fragment-Based Lead DiscoveryBen J. Davis and Stephen D. Roughley12. Antibody-Drug ConjugatesAmit Kumar, Jason White, R. James Christie, Nazzareno Dimasi and Changshou Gao13. Antibody-Recruiting Small Molecules: Synthetic Constructs as ImmunotherapeuticsPatrick J. McEnaney, Christopher G. Parker and Andrew X. Zhang14. A Decade of Deuteration in Medicinal ChemistryJulie F. Liu, Scott L. Harbeson, Christopher L. Brummel, Roger Tung, Robert Silverman and Dario Doller15. From Natural Peptides to MarketClaudio D. Schteingart and Jolene L. Lau