George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.

• Part I - Epidemiology and diagnosis1. History of systemic lupus erythematosus with an emphasis on certain recent major issuesShu Man Fu and Felicia Gaskin2. The patientDonald E. Thomas, Jr.3. A plea of a young patient to the lupus expertsBrianna Fitzpatrick4. EpidemiologyManuel F. Ugarte-Gil, Guillermo J. Pons-Estel and Graciela S. Alarcón5. Measuring disease activityJoan T. Merrill6. Disease development and outcomeMary Mahieu, Dafna Gladman and Rosalind Ramsey-Goldman7. Socioeconomic aspects of SLETitilola Falasinnu and Julia F. Simard8. Biomarkers in systemic lupus erythematosusStacy P. Ardoin and Wael N. JarjourPart II - Pathogenesis9. Overview of the pathogenesis of systemic lupus erythematosusAntonio La Cava10. System lupus erythematosus and the environmentSoad Haj Yahia and Nancy Agmon-Levin11. Genes and genetics in human SLEMara L. Lennard Richard and Betty P. Tsao12. Monogenic lupusMindy S. Lo13. HormonesTakayuki Katsuyama and Vaishali R. Moulton14. Clinical aspects of the complement system in systemic lupus erythematosusJohn P. Atkinson, M. Kathryn Liszewski and C. Yung Yu15. T cellsFlorencia Rosetti and José C. Crispín16. B cells in SLEAndreia C. Lino and Thomas Dörner17. Neutrophils in systemic lupus erythematosusAmr H. Sawalha18. The role of dendritic cells in systemic lupus erythematosusManon Charrier, Christophe Richez, Estibaliz Lazaro, Vanja Sisirak and Patrick Blanco19. CytokinesTakayuki Katsuyama and Vaishali R. Moulton20. RNA/DNA sensing in SLE—Toll-like receptors and beyondCaroline A. Jefferies and Amir Sharabi21. The role of interferons in systemic lupus erythematosusRuth Fernandez-Ruiz and Timothy Niewold22. Fcγ receptors in autoimmunity and endorgan damageT. Ernandez, K. Okubo, G. Saggu and T.N. Mayadas23. Apoptosis, autophagy, and necrosisRoberto Caricchio24. Infections in early systemic lupus erythematosus pathogenesisRebecka Bourn, Samantha Slight-Webb and Judith A. James25. Microbiota influences on systemic lupus erythematosus and Sjögren’s syndromeTeri M. Greiling, Silvio Manfredo Vieira and Martin A. Kriegel26. Origin of autoantibodiesWestley H. Reeves, Shuhong Han and Haoyang Zhuang27. Anti-DNA antibodiesSusan Malkiel, Yemil Atisha-Fregoso and Betty Diamond28. Antihistone and antispliceosome antibodiesMinoru Satoh, Marvin J. Fritzler and Edward K.L. Chan29. Immune complexes in systemic lupus erythematosusKeiju Hiromura and Masaomi Nangaku30. MicroRNA in systemic lupus erythematosusBo Qu, Xiaoyue Jiang and Nan Shen31. Metabolic control of lupus pathogenesis: central role for activation of the mechanistic target of rapamycinAndras Perl32. EpigeneticsChristian M. Hedrich33. What do mouse models teach us about human SLE?Ziaur S.M. Raman and Chandra Mohan34. Genes and genetics of murine systemic lupus erythematosusDwight H. Kono and Argyrios N. TheofilopoulosPart III - Mechanisms of tissue damage35. Mechanisms of renal damage in systemic lupus erythematosusShu Man Fu, Sun-Sang J. Sung, Hongyang Wang, Zhenhuan Zhao and Felicia Gaskin36. Mechanisms of vascular damage in systemic lupus erythematosusSarfaraz A. Hasni and Mariana J. Kaplan37. The mechanism of skin damageXin Huang, Haijing Wu, Christopher Chang and Qianjin Lu38. Pathogenesis of tissue injury in the brain in patients with systemic lupus erythematosusDavid HuntPart IV - Clinical aspects of the disease39. Constitutional symptoms and fatigue in systemic lupus erythematosusSyahrul Sazliyana Shaharir and Caroline Gordon40. The musculoskeletal system in SLEMaria-Louise Barilla-LaBarca, Diane Horowitz, Galina Marder and Richard Furie41. Cutaneous lupus erythematosusAnnegret Kuhn, Aysche Landmann and Gisela Bonsmann42. The clinical evaluation of kidney disease in systemic lupus erythematosusBrad H. Rovin, Isabelle Ayoub and Swati Arora43. The pathology of lupus nephritisIsaac Ely Stillman44. Cardiovascular disease in systemic lupus erythematosus: an updateStephanie Saeli, Tanmayee Bichile, Payal Thakkar and Susan Manzi45. The lung in systemic lupus erythematosusLindsy Forbess, Daniel J. Wallace and Caroline Jefferies46. Gastrointestinal, hepatic, and pancreatic disorders in systemic lupus erythematosusChi Chiu Mok47. Systemic lupus erythematosus and infectionsAmy Devlin and Robert H. Shmerling48. Malignancies in systemic lupus erythematosusAlexandra Ladouceur, Hiromi Tissera, Ann E. Clarke, Rosalind Ramsey-Goldman, Caroline Gordon, James E. Hansen and Sasha Bernatsky49. The nervous system in systemic lupus erythematosusDavid Hunt50. Overlap syndromesEric L. Greidinger51. Systemic lupus erythematosus and the eyeErika M. Damato, Philip I. Murray and Alastair K.O. Denniston52. Fertility and pregnancy in systemic lupus erythematosusBonnie L. Bermas and Lisa R. Sammaritano53. Neonatal lupusClinical spectrum, biomarkers, pathogenesis, and approach to treatmentJill P. Buyon, Amit Saxena, Peter M. Izmirly, Bettina Cuneo and Benjamin Wainwright54. Incomplete lupus syndromesNancy J. Olsen55. Lupus in childrenMindy S. Lo56. Drug-induced lupusRobert L. Rubin57. Vasculitis in lupusAnisur RahmanPart V - Antiphospholipid Syndrome58. Pathogenesis of antiphospholipid syndromeOlga Amengual and Tatsuya Atsumi59. Antibodies and diagnostic tests in antiphosholipid syndromeCecilia Beatrice Chighizola, Maria Orietta Borghi and Pier Luigi Meroni60. Clinical manifestationsMiyuki Bohgaki and Takao Koike61. Nonsteroidal antiinflammatory drugs in systemic lupus erythematosusRobert G. Lahita and Trina Pal62. Value of antimalarial drugs in the treatment of lupusFadi Hassan, Mohammad E. Naffaa and Ziv Paz63. Systemic glucocorticoidsZahi Touma and Murray B. Urowitz64. Cytotoxic drug treatmentEleni A. Frangou, George Bertsias and Dimitrios T. Boumpas65. Treatment of antiphospholipid syndromeSavino Sciascia and Munther Khamashta66. New treatments of systemic lupus erythematosusVasileios C Kyttaris67. Repositioning drugs for systemic lupus erythematosusKathryn M. Kingsmore, Peter E. Lipsky and Amrie C. Grammer

George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.

• Part I - Epidemiology and diagnosis1. History of systemic lupus erythematosus with an emphasis on certain recent major issuesShu Man Fu and Felicia Gaskin2. The patientDonald E. Thomas, Jr.3. A plea of a young patient to the lupus expertsBrianna Fitzpatrick4. EpidemiologyManuel F. Ugarte-Gil, Guillermo J. Pons-Estel and Graciela S. Alarcón5. Measuring disease activityJoan T. Merrill6. Disease development and outcomeMary Mahieu, Dafna Gladman and Rosalind Ramsey-Goldman7. Socioeconomic aspects of SLETitilola Falasinnu and Julia F. Simard8. Biomarkers in systemic lupus erythematosusStacy P. Ardoin and Wael N. JarjourPart II - Pathogenesis9. Overview of the pathogenesis of systemic lupus erythematosusAntonio La Cava10. System lupus erythematosus and the environmentSoad Haj Yahia and Nancy Agmon-Levin11. Genes and genetics in human SLEMara L. Lennard Richard and Betty P. Tsao12. Monogenic lupusMindy S. Lo13. HormonesTakayuki Katsuyama and Vaishali R. Moulton14. Clinical aspects of the complement system in systemic lupus erythematosusJohn P. Atkinson, M. Kathryn Liszewski and C. Yung Yu15. T cellsFlorencia Rosetti and José C. Crispín16. B cells in SLEAndreia C. Lino and Thomas Dörner17. Neutrophils in systemic lupus erythematosusAmr H. Sawalha18. The role of dendritic cells in systemic lupus erythematosusManon Charrier, Christophe Richez, Estibaliz Lazaro, Vanja Sisirak and Patrick Blanco19. CytokinesTakayuki Katsuyama and Vaishali R. Moulton20. RNA/DNA sensing in SLE—Toll-like receptors and beyondCaroline A. Jefferies and Amir Sharabi21. The role of interferons in systemic lupus erythematosusRuth Fernandez-Ruiz and Timothy Niewold22. Fcγ receptors in autoimmunity and endorgan damageT. Ernandez, K. Okubo, G. Saggu and T.N. Mayadas23. Apoptosis, autophagy, and necrosisRoberto Caricchio24. Infections in early systemic lupus erythematosus pathogenesisRebecka Bourn, Samantha Slight-Webb and Judith A. James25. Microbiota influences on systemic lupus erythematosus and Sjögren’s syndromeTeri M. Greiling, Silvio Manfredo Vieira and Martin A. Kriegel26. Origin of autoantibodiesWestley H. Reeves, Shuhong Han and Haoyang Zhuang27. Anti-DNA antibodiesSusan Malkiel, Yemil Atisha-Fregoso and Betty Diamond28. Antihistone and antispliceosome antibodiesMinoru Satoh, Marvin J. Fritzler and Edward K.L. Chan29. Immune complexes in systemic lupus erythematosusKeiju Hiromura and Masaomi Nangaku30. MicroRNA in systemic lupus erythematosusBo Qu, Xiaoyue Jiang and Nan Shen31. Metabolic control of lupus pathogenesis: central role for activation of the mechanistic target of rapamycinAndras Perl32. EpigeneticsChristian M. Hedrich33. What do mouse models teach us about human SLE?Ziaur S.M. Raman and Chandra Mohan34. Genes and genetics of murine systemic lupus erythematosusDwight H. Kono and Argyrios N. TheofilopoulosPart III - Mechanisms of tissue damage35. Mechanisms of renal damage in systemic lupus erythematosusShu Man Fu, Sun-Sang J. Sung, Hongyang Wang, Zhenhuan Zhao and Felicia Gaskin36. Mechanisms of vascular damage in systemic lupus erythematosusSarfaraz A. Hasni and Mariana J. Kaplan37. The mechanism of skin damageXin Huang, Haijing Wu, Christopher Chang and Qianjin Lu38. Pathogenesis of tissue injury in the brain in patients with systemic lupus erythematosusDavid HuntPart IV - Clinical aspects of the disease39. Constitutional symptoms and fatigue in systemic lupus erythematosusSyahrul Sazliyana Shaharir and Caroline Gordon40. The musculoskeletal system in SLEMaria-Louise Barilla-LaBarca, Diane Horowitz, Galina Marder and Richard Furie41. Cutaneous lupus erythematosusAnnegret Kuhn, Aysche Landmann and Gisela Bonsmann42. The clinical evaluation of kidney disease in systemic lupus erythematosusBrad H. Rovin, Isabelle Ayoub and Swati Arora43. The pathology of lupus nephritisIsaac Ely Stillman44. Cardiovascular disease in systemic lupus erythematosus: an updateStephanie Saeli, Tanmayee Bichile, Payal Thakkar and Susan Manzi45. The lung in systemic lupus erythematosusLindsy Forbess, Daniel J. Wallace and Caroline Jefferies46. Gastrointestinal, hepatic, and pancreatic disorders in systemic lupus erythematosusChi Chiu Mok47. Systemic lupus erythematosus and infectionsAmy Devlin and Robert H. Shmerling48. Malignancies in systemic lupus erythematosusAlexandra Ladouceur, Hiromi Tissera, Ann E. Clarke, Rosalind Ramsey-Goldman, Caroline Gordon, James E. Hansen and Sasha Bernatsky49. The nervous system in systemic lupus erythematosusDavid Hunt50. Overlap syndromesEric L. Greidinger51. Systemic lupus erythematosus and the eyeErika M. Damato, Philip I. Murray and Alastair K.O. Denniston52. Fertility and pregnancy in systemic lupus erythematosusBonnie L. Bermas and Lisa R. Sammaritano53. Neonatal lupusClinical spectrum, biomarkers, pathogenesis, and approach to treatmentJill P. Buyon, Amit Saxena, Peter M. Izmirly, Bettina Cuneo and Benjamin Wainwright54. Incomplete lupus syndromesNancy J. Olsen55. Lupus in childrenMindy S. Lo56. Drug-induced lupusRobert L. Rubin57. Vasculitis in lupusAnisur RahmanPart V - Antiphospholipid Syndrome58. Pathogenesis of antiphospholipid syndromeOlga Amengual and Tatsuya Atsumi59. Antibodies and diagnostic tests in antiphosholipid syndromeCecilia Beatrice Chighizola, Maria Orietta Borghi and Pier Luigi Meroni60. Clinical manifestationsMiyuki Bohgaki and Takao Koike61. Nonsteroidal antiinflammatory drugs in systemic lupus erythematosusRobert G. Lahita and Trina Pal62. Value of antimalarial drugs in the treatment of lupusFadi Hassan, Mohammad E. Naffaa and Ziv Paz63. Systemic glucocorticoidsZahi Touma and Murray B. Urowitz64. Cytotoxic drug treatmentEleni A. Frangou, George Bertsias and Dimitrios T. Boumpas65. Treatment of antiphospholipid syndromeSavino Sciascia and Munther Khamashta66. New treatments of systemic lupus erythematosusVasileios C Kyttaris67. Repositioning drugs for systemic lupus erythematosusKathryn M. Kingsmore, Peter E. Lipsky and Amrie C. Grammer

George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.

• Part I - Epidemiology and diagnosis1. History of systemic lupus erythematosus with an emphasis on certain recent major issuesShu Man Fu and Felicia Gaskin2. The patientDonald E. Thomas, Jr.3. A plea of a young patient to the lupus expertsBrianna Fitzpatrick4. EpidemiologyManuel F. Ugarte-Gil, Guillermo J. Pons-Estel and Graciela S. Alarcón5. Measuring disease activityJoan T. Merrill6. Disease development and outcomeMary Mahieu, Dafna Gladman and Rosalind Ramsey-Goldman7. Socioeconomic aspects of SLETitilola Falasinnu and Julia F. Simard8. Biomarkers in systemic lupus erythematosusStacy P. Ardoin and Wael N. JarjourPart II - Pathogenesis9. Overview of the pathogenesis of systemic lupus erythematosusAntonio La Cava10. System lupus erythematosus and the environmentSoad Haj Yahia and Nancy Agmon-Levin11. Genes and genetics in human SLEMara L. Lennard Richard and Betty P. Tsao12. Monogenic lupusMindy S. Lo13. HormonesTakayuki Katsuyama and Vaishali R. Moulton14. Clinical aspects of the complement system in systemic lupus erythematosusJohn P. Atkinson, M. Kathryn Liszewski and C. Yung Yu15. T cellsFlorencia Rosetti and José C. Crispín16. B cells in SLEAndreia C. Lino and Thomas Dörner17. Neutrophils in systemic lupus erythematosusAmr H. Sawalha18. The role of dendritic cells in systemic lupus erythematosusManon Charrier, Christophe Richez, Estibaliz Lazaro, Vanja Sisirak and Patrick Blanco19. CytokinesTakayuki Katsuyama and Vaishali R. Moulton20. RNA/DNA sensing in SLE—Toll-like receptors and beyondCaroline A. Jefferies and Amir Sharabi21. The role of interferons in systemic lupus erythematosusRuth Fernandez-Ruiz and Timothy Niewold22. Fcγ receptors in autoimmunity and endorgan damageT. Ernandez, K. Okubo, G. Saggu and T.N. Mayadas23. Apoptosis, autophagy, and necrosisRoberto Caricchio24. Infections in early systemic lupus erythematosus pathogenesisRebecka Bourn, Samantha Slight-Webb and Judith A. James25. Microbiota influences on systemic lupus erythematosus and Sjögren’s syndromeTeri M. Greiling, Silvio Manfredo Vieira and Martin A. Kriegel26. Origin of autoantibodiesWestley H. Reeves, Shuhong Han and Haoyang Zhuang27. Anti-DNA antibodiesSusan Malkiel, Yemil Atisha-Fregoso and Betty Diamond28. Antihistone and antispliceosome antibodiesMinoru Satoh, Marvin J. Fritzler and Edward K.L. Chan29. Immune complexes in systemic lupus erythematosusKeiju Hiromura and Masaomi Nangaku30. MicroRNA in systemic lupus erythematosusBo Qu, Xiaoyue Jiang and Nan Shen31. Metabolic control of lupus pathogenesis: central role for activation of the mechanistic target of rapamycinAndras Perl32. EpigeneticsChristian M. Hedrich33. What do mouse models teach us about human SLE?Ziaur S.M. Raman and Chandra Mohan34. Genes and genetics of murine systemic lupus erythematosusDwight H. Kono and Argyrios N. TheofilopoulosPart III - Mechanisms of tissue damage35. Mechanisms of renal damage in systemic lupus erythematosusShu Man Fu, Sun-Sang J. Sung, Hongyang Wang, Zhenhuan Zhao and Felicia Gaskin36. Mechanisms of vascular damage in systemic lupus erythematosusSarfaraz A. Hasni and Mariana J. Kaplan37. The mechanism of skin damageXin Huang, Haijing Wu, Christopher Chang and Qianjin Lu38. Pathogenesis of tissue injury in the brain in patients with systemic lupus erythematosusDavid HuntPart IV - Clinical aspects of the disease39. Constitutional symptoms and fatigue in systemic lupus erythematosusSyahrul Sazliyana Shaharir and Caroline Gordon40. The musculoskeletal system in SLEMaria-Louise Barilla-LaBarca, Diane Horowitz, Galina Marder and Richard Furie41. Cutaneous lupus erythematosusAnnegret Kuhn, Aysche Landmann and Gisela Bonsmann42. The clinical evaluation of kidney disease in systemic lupus erythematosusBrad H. Rovin, Isabelle Ayoub and Swati Arora43. The pathology of lupus nephritisIsaac Ely Stillman44. Cardiovascular disease in systemic lupus erythematosus: an updateStephanie Saeli, Tanmayee Bichile, Payal Thakkar and Susan Manzi45. The lung in systemic lupus erythematosusLindsy Forbess, Daniel J. Wallace and Caroline Jefferies46. Gastrointestinal, hepatic, and pancreatic disorders in systemic lupus erythematosusChi Chiu Mok47. Systemic lupus erythematosus and infectionsAmy Devlin and Robert H. Shmerling48. Malignancies in systemic lupus erythematosusAlexandra Ladouceur, Hiromi Tissera, Ann E. Clarke, Rosalind Ramsey-Goldman, Caroline Gordon, James E. Hansen and Sasha Bernatsky49. The nervous system in systemic lupus erythematosusDavid Hunt50. Overlap syndromesEric L. Greidinger51. Systemic lupus erythematosus and the eyeErika M. Damato, Philip I. Murray and Alastair K.O. Denniston52. Fertility and pregnancy in systemic lupus erythematosusBonnie L. Bermas and Lisa R. Sammaritano53. Neonatal lupusClinical spectrum, biomarkers, pathogenesis, and approach to treatmentJill P. Buyon, Amit Saxena, Peter M. Izmirly, Bettina Cuneo and Benjamin Wainwright54. Incomplete lupus syndromesNancy J. Olsen55. Lupus in childrenMindy S. Lo56. Drug-induced lupusRobert L. Rubin57. Vasculitis in lupusAnisur RahmanPart V - Antiphospholipid Syndrome58. Pathogenesis of antiphospholipid syndromeOlga Amengual and Tatsuya Atsumi59. Antibodies and diagnostic tests in antiphosholipid syndromeCecilia Beatrice Chighizola, Maria Orietta Borghi and Pier Luigi Meroni60. Clinical manifestationsMiyuki Bohgaki and Takao Koike61. Nonsteroidal antiinflammatory drugs in systemic lupus erythematosusRobert G. Lahita and Trina Pal62. Value of antimalarial drugs in the treatment of lupusFadi Hassan, Mohammad E. Naffaa and Ziv Paz63. Systemic glucocorticoidsZahi Touma and Murray B. Urowitz64. Cytotoxic drug treatmentEleni A. Frangou, George Bertsias and Dimitrios T. Boumpas65. Treatment of antiphospholipid syndromeSavino Sciascia and Munther Khamashta66. New treatments of systemic lupus erythematosusVasileios C Kyttaris67. Repositioning drugs for systemic lupus erythematosusKathryn M. Kingsmore, Peter E. Lipsky and Amrie C. Grammer