Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Dr Bonavida has vast expertise and various reported publications in the field of tumor cell sensitization to chemotherapy (a total of greater than 500 publications) and in particular the novel role of Nitric Oxide (NO) donors in chemo-sensitization and reversal of drug resistance. In addition, he was the first scientist to co-organize an international meeting on the topic (First International Workshop on NO and Cancer, 2005).Zhe-Sheng Chen opened the St. John’s University’s first cancer pharmacology laboratory. His research interest is multidrug resistance and its reversal, novel anti-cancer drug development. Chen serves as Editor of "African Journal of Pharmacy and Pharmacology"; Editor-in-Chief of “Journal of Cancer Research Updates" and "Journal of New Developments in Chemistry". He also serves as an Editorial Board member of 25 journals, an Ad Hoc reviewer of 180 journals, and a guest editor of "Current Pharmaceutical Biotechnology", "Cancer" and "Journal of International Medical Research". Chen has over 170 papers published, 6 book chapters, and 5 patents. Dong-Hua Yang is an Assistant Professor at St. John’s University College of Pharmacy and Health Sciences. She works in the fields of Cancer Biomarkers and Cancer Pharmacology. Before joining St. John’s, she was a Research Assistant Professor at Fox Chase Cancer Center, where she took charge of the Tissue Research Service at the Biosample Repository Core Facility. She is a leading expert in the field of immunohistochemistry (IHC) and IHC quantitative analysis. She applied IHC technology to study the molecular alterations of known and novel signaling pathways that regulate embryogenesis, organ morphogenesis and tumorigenesis. Yang leads the automatic quantitative analysis (AQUA) for immunohistochemistry and immunofluorescence assays for biomarker research. Yang is the regional editor of “Current Proteomics”, guest editor of “Frontiers of Pharmacology”, “Cancers” and “Molecules”, associate editor of “ Journal of Nutritional Therapeutics”, “Journal of Cancer Research Updates” and “Journal of Analytical Oncology”, ad hoc reviewer of 0ver 50 journals. Yang has over 70 papers and 4 book chapters published.

• 1. EGFR and HER2 inhibitors as sensitizing agents for cancer chemotherapy2. BCR-ABL inhibitors as sensitizing agents for cancer chemotherapy3. VEGFR inhibitors as sensitizing agents for cancer chemotherapy4. ALK inhibitors as sensitizing agents for cancer chemotherapy5. JAK2 inhibitors as sensitizing agents for cancer chemotherapy6. FLT3 inhibitors as sensitizing agents for cancer chemotherapy7. BRAF inhibitors as sensitizing agents for cancer chemotherapy8. Bruton kinase inhibitors as sensitizing agents for cancer chemotherapy