Breathborne Biomarkers and the Human Volatilome

Jonathan Beauchamp is manager of the Emissions Analytics and Diagnostics group at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising, Germany. He has been involved in academic and industrial breath research for the past 15 years and is currently principal investigator in several breath-related projects. He is an active member and current treasurer of the International Association of Breath Research (IABR). Cristina Davis is chair and professor of Mechanical and Aerospace Engineering at the University of California Davis, United States. Her research focuses on development of novel chemical and biological sensor systems and biomarker identification in agriculture and human/animal health monitoring. She has 12 issued patents and has coauthored over 100 peer-reviewed journal articles and book chapters. She is current chair-elect of IABR. Joachim Pleil is adjunct professor at the University of North Carolina, School of Public Health, United States. He has published over 150 journal articles, many involving breath biomarker research and statistical interpretation of breath-based data. He has retired from US Environmental Protection Agency after 32 years as a research scientist. He is currently a consultant for NASA on a pilot breathing assessment project and is a founding member of IABR.

• PART A: Concepts and modeling1. Breath biomakers and the exposome2. Breath sampling and standardization3. Physiological modeling of exhaled compounds4. Exhaled nitric oxide physiology and modelingPART B: Inorganics and non-volatiles5. Exhaled nitric oxide in clinical practice6. Exhaled carbon monoxide7. Exhaled breath condensate and aerosol8. Exhaled particlesPART C: Analytics9. Selected ion flow tube mass spectrometry10. Proton transfer reaction—mass spectrometry11. Ion mobility spectrometry12. Secondary electrospray ionization13. Sensor systems14. Optical spectroscopy15. Comprehensive gas chromatography-mass spectrometry16. High-resolution mass spectrometryPART D: Breath tests17. 13C breath tests18. Breath monitoring in the intensive care unit19. Chronic obstructive pulmonary disease and smokers20. Clinical phenotyping21. Breath analysis for respiratory infections22. Volatile biomarkers of malaria infection23. Lifestyle applicationsPART E: Beyond human breath24. Biomarkers in urine and stool25. Volatile emissions from skin26. Cell cultures as in vitro models for breath research27. Ruminants28. Breath analysis in marine mammalsPART F: Field applications29. Breath analysis in law enforcement30. Drugs in breath31. Urban search and rescue32. Breath analysis in occupational medicine33. Breath biomarkers in human xenobiotic exposure studies34. Canine olfactionPART G: Design and interpretation35. Clinical study design36. Challenges in clinical breath research development37. Mathematical interpretation of targeted volatilome data38. Preprocessing and analysis of volatilome data39. Applications of the US EPA CompTox Chemicals Dashboard to support mass spectrometry and breath research