From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

Christopher Langmead is at Monash University, Vic, Australia

• The computational modeling of allosteric modulation of metabotropic glutamate receptorsLaura Pérez-Benito, Claudia Llinas del Torrent, Leonardo Pardo and Gary TresadernStructure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulatorsKirstie A. Bennett, John A. Christopher and Benjamin G. TehanThe function and allosteric control of the human sweet taste receptorGuy Servant, Terry Kenakin, Lan Zhang, Mark Williams and Nicole ServantThe different aspects of the GABAB receptor allosteric modulationJulie KniazeffRAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptorsAugen A. Pioszak and Debbie L. HayStrategies and considerations of G-protein-coupled receptor photopharmacologyAlice E. Berizzi and Cyril GoudetDiscovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP. A novel tool to probe GLP-1R pharmacologyFrancis S. Willard, Joseph D. Ho and Kyle W. SloopAllosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigationsKari A. Johnson and David M. LovingerAllosteric modulation of muscarinic receptors in alcohol and substance use disordersLeigh C. Walker and Andrew J. LawrenceM1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease? Miriam Scarpa, Sarah Hesse and Sophie J. Bradley