The Design and Development of Novel Drugs and Vaccines

Tarun Kumar Bhatt is an Assistant Professor in the Department of Biotechnology, at the Central University of Rajasthan, India. He received his PhD from the International Centre for Genetic Engineering and Biotechnology, New Delhi and gained post-doctoral experience at the Scripps Research Institute in San Diego, California. He has published over 25 articles and has extensive experience researching drug and vaccine development. Surendra Nimesh, UGC Assistant Professor at Central University of Rajasthan, Rajasthan, India. Surendra received his M.S. in Biomedical Science from the Dr. B.R. Ambedkar Center for Biomedical Research (ACBR), University of Delhi. He completed his PhD. In Nanotechnology at the Institute of Genomics and Integrative Biology (CSIR), Delhi. After completing his postdoctoral studies at the Ecole Polyetchnique of Montreal, Surendra joined the Clinical Research Institute of Montreal (IRCM), Canada as Postdoctoral Fellow. After completing his commitment at IRCM, he joined McGill University for short time. He also worked as NSERC visiting fellow at Health Canada, Canada. His research interests include nanoparticles-mediated gene, siRNA and drug delivery.

"I have read other books on clinical research, but none with the level of detail and particular focus on drug design (the computational drug design sections) that this one has. This book is very detailed-oriented from that standpoint, and it can certainly serve as a useful tool for those developing vaccines." --© Doody’s Review Service, 2021, Patrick J Scoble, PharmD(PJS Pharma Consulting LLC), reviewer, expert opinion

• 1. Introduction of structural bioinformatics with respect to drug discovery2. Target identification and validation3. Retrieval of compounds4. Lead identification and optimization5. Molecular dynamics simulations6. An overview of vaccine design7. Key steps in the selection of vaccine targets8. Epitope prediction and selection of linkers and adjuvant9. Design of vaccine constructs10. In-silico validation through protein-protein docking11. Molecular cloning12. Protein expression13. Protein purification and desalting14. Biological assay15. Biophysical methods16. Outline of animal study for lead/ vaccine testing17. Evaluation of immunogenicity of vaccine candidate18. In-vitro evaluation of lead molecule19. Medical physiological parameter for lead/vaccine testing20. Brief introduction of clinical research and trials21. An overview of IND, NDA, approval agencies and FDA post-marketing surveillance22. Introduction of Intellectual property rights