Nima Rezaei, MD, PhD, is Professor of Clinical Immunology and Allergy at Tehran University of Medical Sciences, where he also serves as Associate Dean of International Affairs for the School of Medicine and Director of the Global Academic Program. He is Deputy President of the Research Center for Immunodeficiencies and holds an affiliated research appointment in the Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet, Sweden. He earned his MD from Tehran University of Medical Sciences and his PhD in Clinical Immunology and Human Genetics from the University of Sheffield, United Kingdom. His research addresses primary immunodeficiencies and translational immunology, with recent work extending into computational and AI-based approaches to immune profiling. He is the founder and President of the Universal Scientific Education and Research Network (USERN) and serves as co-editor of the Springer Nature series Advances in Experimental Medicine and Biology.Parnian Jabbari is a Medical Doctor at Tehran University of Medical Sciences, and a member of the Network of Immunity in Infection, Malignancy & Autoimmunity (NIIMA). She also works with the Universal Scientific Education & Research Network (USERN), based in Tehran, Iran.

• Section I1. Introduciton to cancer immunology2. Introduction to bioinformatics3. Practical databases in immunoinformaticsSection II4. Principles of R programming5. R programming in bioinformatics6. Principle R packages in immunoinformaticsSection III7. Introduction to machine learning8. Naïve Bayes in R9. Regressions in R10. Linear and quadratic discriminant analysis11. Support-vector Machine in R12. Decision trees in R13. Random forests in R14. Neural Network in R15. K Nearest Neighbour in R16. Practice examples