John A. Kellum is a Professor and Vice Chair of the Department of Critical Care Medicine at the University of Pittsburgh Medical Center in Pittsburgh, Pennsylvania. Rinaldo Bellomo is a Professor of Medicine and Director of Intensive Care Research at Melbourne University in Melbourne, Australia. Claudio Ronco is a Professor of Clinical Nephrology and Medicine and Director of the Department of Nephrology at St. Bortolo Hospital in Vicenza, Italy.

"The real success of this book is that it is the most complete yet concise reference book available on this important and ever-more present therapy. Moreover, it takes complex topics and makes them accessible to clinicians who are at the beginning of their training, but manages to add new layers of information for the more seasoned physicians." -International Anesthesia Research Society

• Part 1: Theory Chapter 1The Critically Ill Patient with Acute Kidney InjuryAditya Uppalapati and John A. Kellum Chapter 2History and Rationale for CRRTIlona Bobek and Claudio Ronco Chapter 3Nomenclature for Renal Replacement Therapy in Acute Kidney InjuryMauro Neri, Jorge Cerda, Francesco Garzotto, Gianluca Villa, and Claudio Ronco Chapter 4Basic Principles of Solute TransportZhongping Huang, Jeffrey J. Letteri, Claudio Ronco, and William R. Clark Chapter 5Principles of Fluid Management in the ICURinaldo Bellomo and Sean M. Bagshaw Chapter 6Indications, Timing, and Patient SelectionJohn A. Kellum, Raghavan Murugan, and Mitra Nadim Chapter 7Biomarkers for Initiation of Renal Replacement TherapyAlexander Zarbock and Lakhmir S. Chawla Chapter 8Extended IndicationsRinaldo Bellomo and Ian Baldwin Chapter 9Dose Adequacy and AssessmentZaccaria Ricci and Claudio Ronco Chapter 10Acid-base and Electrolyte DisordersJohn A. Kellum Part 2: Practice Chapter 11Choosing a Renal Replacement Therapy in Acute Kidney InjuryJorge Cerdá and Claudio Ronco Chapter 12Vascular Access for Continuous Renal Replacement TherapyAlexander Zarbock and Kai Singbart Chapter 13The Circuit and the PrescriptionRinaldo Bellomo and Ian Baldwin Chapter 14The Membrane: Size and MaterialZhongping Huang, Jeffrey J. Letteri, Claudio Ronco, and William R. Clark Chapter 15Fluids for Continuous Renal Replacement TherapyPaul M. Palevsky and John A. Kellum Chapter 16Alarms and TroubleshootingZaccaria Ricci, Ian Baldwin, and Claudio Ronco Chapter 17Non Anticoagulation Strategies to Optimise Circuit Function in RRTIan Baldwin Chapter 18 Anticoagulation Rinaldo Bellomo and Ian Baldwin Chapter 19Regional Citrate AnticoagulationNigel Fealy Chapter 20Drug Dosing in Continuous Renal Replacement TherapyAdrian Wong, Sandra L. Kane-Gill, and John A. Kellum Part 3: Special Situations Chapter 21Renal Replacement Therapy in ChildrenMichael L. Moritz Chapter 22Therapeutic Plasma Exchange in Critical Care MedicineJoseph E. Kiss Chapter 23MARS: Molecular Adsorbent Recirculating SystemNigel Fealy and Rinaldo Bellomo Chapter 24SorbentsDehua Gong and Claudio Ronco Chapter 25Hybrid TherapiesDinna N. Cruz and Claudio Ronco Part 4: Organizational Issues Chapter 26The ICU EnvironmentAyan Sen Chapter 27Patient Care Quality and TeamworkKimberly Whiteman and Frederick J. TasotaChapter 28Organizational Aspects: Developing Policies and Procedures for Continuous Renal Replacement Therapies (CRRT)Jorge Cerdá Chapter 29Documentation, Billing, and Reimbursement for Continuous Renal Replacement TherapyKevin W. Finkel Chapter 30Machines for CRRTLakhmir S. Chawla and Claudio Ronco Chapter 31Quality Improvement for Continuous Renal Replacement TherapiesIan Baldwin and Rinaldo Bellomo Chapter 32Educational ResourcesIan Baldwin and Kimberly Whiteman

John A. Kellum is a Professor and Vice Chair of the Department of Critical Care Medicine at the University of Pittsburgh Medical Center in Pittsburgh, Pennsylvania. Rinaldo Bellomo is a Professor of Medicine and Director of Intensive Care Research at Melbourne University in Melbourne, Australia. Claudio Ronco is a Professor of Clinical Nephrology and Medicine and Director of the Department of Nephrology at St. Bortolo Hospital in Vicenza, Italy.

"The real success of this book is that it is the most complete yet concise reference book available on this important and ever-more present therapy. Moreover, it takes complex topics and makes them accessible to clinicians who are at the beginning of their training, but manages to add new layers of information for the more seasoned physicians." -International Anesthesia Research Society

• Part 1: Theory Chapter 1The Critically Ill Patient with Acute Kidney InjuryAditya Uppalapati and John A. Kellum Chapter 2History and Rationale for CRRTIlona Bobek and Claudio Ronco Chapter 3Nomenclature for Renal Replacement Therapy in Acute Kidney InjuryMauro Neri, Jorge Cerda, Francesco Garzotto, Gianluca Villa, and Claudio Ronco Chapter 4Basic Principles of Solute TransportZhongping Huang, Jeffrey J. Letteri, Claudio Ronco, and William R. Clark Chapter 5Principles of Fluid Management in the ICURinaldo Bellomo and Sean M. Bagshaw Chapter 6Indications, Timing, and Patient SelectionJohn A. Kellum, Raghavan Murugan, and Mitra Nadim Chapter 7Biomarkers for Initiation of Renal Replacement TherapyAlexander Zarbock and Lakhmir S. Chawla Chapter 8Extended IndicationsRinaldo Bellomo and Ian Baldwin Chapter 9Dose Adequacy and AssessmentZaccaria Ricci and Claudio Ronco Chapter 10Acid-base and Electrolyte DisordersJohn A. Kellum Part 2: Practice Chapter 11Choosing a Renal Replacement Therapy in Acute Kidney InjuryJorge Cerdá and Claudio Ronco Chapter 12Vascular Access for Continuous Renal Replacement TherapyAlexander Zarbock and Kai Singbart Chapter 13The Circuit and the PrescriptionRinaldo Bellomo and Ian Baldwin Chapter 14The Membrane: Size and MaterialZhongping Huang, Jeffrey J. Letteri, Claudio Ronco, and William R. Clark Chapter 15Fluids for Continuous Renal Replacement TherapyPaul M. Palevsky and John A. Kellum Chapter 16Alarms and TroubleshootingZaccaria Ricci, Ian Baldwin, and Claudio Ronco Chapter 17Non Anticoagulation Strategies to Optimise Circuit Function in RRTIan Baldwin Chapter 18 Anticoagulation Rinaldo Bellomo and Ian Baldwin Chapter 19Regional Citrate AnticoagulationNigel Fealy Chapter 20Drug Dosing in Continuous Renal Replacement TherapyAdrian Wong, Sandra L. Kane-Gill, and John A. Kellum Part 3: Special Situations Chapter 21Renal Replacement Therapy in ChildrenMichael L. Moritz Chapter 22Therapeutic Plasma Exchange in Critical Care MedicineJoseph E. Kiss Chapter 23MARS: Molecular Adsorbent Recirculating SystemNigel Fealy and Rinaldo Bellomo Chapter 24SorbentsDehua Gong and Claudio Ronco Chapter 25Hybrid TherapiesDinna N. Cruz and Claudio Ronco Part 4: Organizational Issues Chapter 26The ICU EnvironmentAyan Sen Chapter 27Patient Care Quality and TeamworkKimberly Whiteman and Frederick J. TasotaChapter 28Organizational Aspects: Developing Policies and Procedures for Continuous Renal Replacement Therapies (CRRT)Jorge Cerdá Chapter 29Documentation, Billing, and Reimbursement for Continuous Renal Replacement TherapyKevin W. Finkel Chapter 30Machines for CRRTLakhmir S. Chawla and Claudio Ronco Chapter 31Quality Improvement for Continuous Renal Replacement TherapiesIan Baldwin and Rinaldo Bellomo Chapter 32Educational ResourcesIan Baldwin and Kimberly Whiteman

John A. Kellum is a Professor and Vice Chair of the Department of Critical Care Medicine at the University of Pittsburgh Medical Center in Pittsburgh, Pennsylvania. Rinaldo Bellomo is a Professor of Medicine and Director of Intensive Care Research at Melbourne University in Melbourne, Australia. Claudio Ronco is a Professor of Clinical Nephrology and Medicine and Director of the Department of Nephrology at St. Bortolo Hospital in Vicenza, Italy.

"The real success of this book is that it is the most complete yet concise reference book available on this important and ever-more present therapy. Moreover, it takes complex topics and makes them accessible to clinicians who are at the beginning of their training, but manages to add new layers of information for the more seasoned physicians." -International Anesthesia Research Society

• Part 1: Theory Chapter 1The Critically Ill Patient with Acute Kidney InjuryAditya Uppalapati and John A. Kellum Chapter 2History and Rationale for CRRTIlona Bobek and Claudio Ronco Chapter 3Nomenclature for Renal Replacement Therapy in Acute Kidney InjuryMauro Neri, Jorge Cerda, Francesco Garzotto, Gianluca Villa, and Claudio Ronco Chapter 4Basic Principles of Solute TransportZhongping Huang, Jeffrey J. Letteri, Claudio Ronco, and William R. Clark Chapter 5Principles of Fluid Management in the ICURinaldo Bellomo and Sean M. Bagshaw Chapter 6Indications, Timing, and Patient SelectionJohn A. Kellum, Raghavan Murugan, and Mitra Nadim Chapter 7Biomarkers for Initiation of Renal Replacement TherapyAlexander Zarbock and Lakhmir S. Chawla Chapter 8Extended IndicationsRinaldo Bellomo and Ian Baldwin Chapter 9Dose Adequacy and AssessmentZaccaria Ricci and Claudio Ronco Chapter 10Acid-base and Electrolyte DisordersJohn A. Kellum Part 2: Practice Chapter 11Choosing a Renal Replacement Therapy in Acute Kidney InjuryJorge Cerdá and Claudio Ronco Chapter 12Vascular Access for Continuous Renal Replacement TherapyAlexander Zarbock and Kai Singbart Chapter 13The Circuit and the PrescriptionRinaldo Bellomo and Ian Baldwin Chapter 14The Membrane: Size and MaterialZhongping Huang, Jeffrey J. Letteri, Claudio Ronco, and William R. Clark Chapter 15Fluids for Continuous Renal Replacement TherapyPaul M. Palevsky and John A. Kellum Chapter 16Alarms and TroubleshootingZaccaria Ricci, Ian Baldwin, and Claudio Ronco Chapter 17Non Anticoagulation Strategies to Optimise Circuit Function in RRTIan Baldwin Chapter 18 Anticoagulation Rinaldo Bellomo and Ian Baldwin Chapter 19Regional Citrate AnticoagulationNigel Fealy Chapter 20Drug Dosing in Continuous Renal Replacement TherapyAdrian Wong, Sandra L. Kane-Gill, and John A. Kellum Part 3: Special Situations Chapter 21Renal Replacement Therapy in ChildrenMichael L. Moritz Chapter 22Therapeutic Plasma Exchange in Critical Care MedicineJoseph E. Kiss Chapter 23MARS: Molecular Adsorbent Recirculating SystemNigel Fealy and Rinaldo Bellomo Chapter 24SorbentsDehua Gong and Claudio Ronco Chapter 25Hybrid TherapiesDinna N. Cruz and Claudio Ronco Part 4: Organizational Issues Chapter 26The ICU EnvironmentAyan Sen Chapter 27Patient Care Quality and TeamworkKimberly Whiteman and Frederick J. TasotaChapter 28Organizational Aspects: Developing Policies and Procedures for Continuous Renal Replacement Therapies (CRRT)Jorge Cerdá Chapter 29Documentation, Billing, and Reimbursement for Continuous Renal Replacement TherapyKevin W. Finkel Chapter 30Machines for CRRTLakhmir S. Chawla and Claudio Ronco Chapter 31Quality Improvement for Continuous Renal Replacement TherapiesIan Baldwin and Rinaldo Bellomo Chapter 32Educational ResourcesIan Baldwin and Kimberly Whiteman