Eduardo E. BenarrochProfessor of NeurologyDepartment of Neurology, Mayo Clinic, Rochester, MN

The book is an easy-to-read recapitulation of basic neuroscience concepts and mechanisms important for the development of disorders. It can almost be considered a hands-on manual serving as a quick reminder of where, how, and why some disorders develop. The content is reader-friendly, with a brief introduction and key messages listed at the end of each chapter.

• Preface Section I: Molecular and Cellular MechanismsCh1. Overview: Cellular Components of the Nervous System and Disease MechanismsCh2. Organization of the Cell MembranesCh3. Intracellular SignalingCh4. DNA: Epigenetic Control of Transcription and Repair MechanismsCh5. RNA Metabolism and Control of TranslationCh6. Proteostasis Ch7. Vesicular Trafficking Ch8. CytoskeletonCh9. Axonal Transport Ch10. Axon and MyelinCh11. Mitochondria and Energy MetabolismCh12. Mechanisms of Cell Death and Axonal DegenerationCh13. Growth Factors, Survival, and Regeneration Section II: Excitability, Signal Communication, and Plasticity Ch14. Ion Channels and ChannelopathiesCh15. Principles of Synaptic Transmission and Presynaptic SynaptopahiesCh16. Neurotransmission, Neuromodulation, and PlasticityCh17. Glutamatergic Transmission, Plasticity and SynaptopahiesCh18. Inhibitory Amino Acid Transmission and SynaptopahiesCh19. Cholinergic Transmission Ch20. Monoaminergic Neurotransmission Section III: Microenvironment and Mechanisms of Injury and repairCh21. Astrocyte-Neuron InteractionsCh22. Neuronal MicroenvironmentCh23. Microglia and Inflammation in the Nervous System Section III: Neuronal Interactions in Cortical and Subcortical Circuits Ch24. Neocortical CircuitsCh25. Hippocampal and Amygdala CircuitsCh26. Thalamocortical InteractionsCh27. Sleep Ch28. Behavioral State Control Ch29. Sensory ProcessingCh30. Cortical Motor Control Ch31. Segmental Spinal Motor ControlCh32. Brainstem Motor Control Ch33. CerbellumCh34. Basal ganglia Section V: Homeostatic Systems Ch35. NociceptorsCh36. Central Pain Processing and Modulation Ch37. Autonomic Nervous SystemCh38. Forebrain Control of Homeostasis and Adaptation Section VI: Cortical Networks and Cognitive DomainsCh39. Emotion and Social CognitionCh40. Episodic Memory, Navigation, and Inner Thoughts Ch41. Language, Speech, and Semantic CognitionCh42. Cortical Executive Networks and High-level Behavioral and Cognitive Control

Eduardo E. BenarrochProfessor of NeurologyDepartment of Neurology, Mayo Clinic, Rochester, MN

The book is an easy-to-read recapitulation of basic neuroscience concepts and mechanisms important for the development of disorders. It can almost be considered a hands-on manual serving as a quick reminder of where, how, and why some disorders develop. The content is reader-friendly, with a brief introduction and key messages listed at the end of each chapter.

• Preface Section I: Molecular and Cellular MechanismsCh1. Overview: Cellular Components of the Nervous System and Disease MechanismsCh2. Organization of the Cell MembranesCh3. Intracellular SignalingCh4. DNA: Epigenetic Control of Transcription and Repair MechanismsCh5. RNA Metabolism and Control of TranslationCh6. Proteostasis Ch7. Vesicular Trafficking Ch8. CytoskeletonCh9. Axonal Transport Ch10. Axon and MyelinCh11. Mitochondria and Energy MetabolismCh12. Mechanisms of Cell Death and Axonal DegenerationCh13. Growth Factors, Survival, and Regeneration Section II: Excitability, Signal Communication, and Plasticity Ch14. Ion Channels and ChannelopathiesCh15. Principles of Synaptic Transmission and Presynaptic SynaptopahiesCh16. Neurotransmission, Neuromodulation, and PlasticityCh17. Glutamatergic Transmission, Plasticity and SynaptopahiesCh18. Inhibitory Amino Acid Transmission and SynaptopahiesCh19. Cholinergic Transmission Ch20. Monoaminergic Neurotransmission Section III: Microenvironment and Mechanisms of Injury and repairCh21. Astrocyte-Neuron InteractionsCh22. Neuronal MicroenvironmentCh23. Microglia and Inflammation in the Nervous System Section III: Neuronal Interactions in Cortical and Subcortical Circuits Ch24. Neocortical CircuitsCh25. Hippocampal and Amygdala CircuitsCh26. Thalamocortical InteractionsCh27. Sleep Ch28. Behavioral State Control Ch29. Sensory ProcessingCh30. Cortical Motor Control Ch31. Segmental Spinal Motor ControlCh32. Brainstem Motor Control Ch33. CerbellumCh34. Basal ganglia Section V: Homeostatic Systems Ch35. NociceptorsCh36. Central Pain Processing and Modulation Ch37. Autonomic Nervous SystemCh38. Forebrain Control of Homeostasis and Adaptation Section VI: Cortical Networks and Cognitive DomainsCh39. Emotion and Social CognitionCh40. Episodic Memory, Navigation, and Inner Thoughts Ch41. Language, Speech, and Semantic CognitionCh42. Cortical Executive Networks and High-level Behavioral and Cognitive Control

Eduardo E. BenarrochProfessor of NeurologyDepartment of Neurology, Mayo Clinic, Rochester, MN

The book is an easy-to-read recapitulation of basic neuroscience concepts and mechanisms important for the development of disorders. It can almost be considered a hands-on manual serving as a quick reminder of where, how, and why some disorders develop. The content is reader-friendly, with a brief introduction and key messages listed at the end of each chapter.

• Preface Section I: Molecular and Cellular MechanismsCh1. Overview: Cellular Components of the Nervous System and Disease MechanismsCh2. Organization of the Cell MembranesCh3. Intracellular SignalingCh4. DNA: Epigenetic Control of Transcription and Repair MechanismsCh5. RNA Metabolism and Control of TranslationCh6. Proteostasis Ch7. Vesicular Trafficking Ch8. CytoskeletonCh9. Axonal Transport Ch10. Axon and MyelinCh11. Mitochondria and Energy MetabolismCh12. Mechanisms of Cell Death and Axonal DegenerationCh13. Growth Factors, Survival, and Regeneration Section II: Excitability, Signal Communication, and Plasticity Ch14. Ion Channels and ChannelopathiesCh15. Principles of Synaptic Transmission and Presynaptic SynaptopahiesCh16. Neurotransmission, Neuromodulation, and PlasticityCh17. Glutamatergic Transmission, Plasticity and SynaptopahiesCh18. Inhibitory Amino Acid Transmission and SynaptopahiesCh19. Cholinergic Transmission Ch20. Monoaminergic Neurotransmission Section III: Microenvironment and Mechanisms of Injury and repairCh21. Astrocyte-Neuron InteractionsCh22. Neuronal MicroenvironmentCh23. Microglia and Inflammation in the Nervous System Section III: Neuronal Interactions in Cortical and Subcortical Circuits Ch24. Neocortical CircuitsCh25. Hippocampal and Amygdala CircuitsCh26. Thalamocortical InteractionsCh27. Sleep Ch28. Behavioral State Control Ch29. Sensory ProcessingCh30. Cortical Motor Control Ch31. Segmental Spinal Motor ControlCh32. Brainstem Motor Control Ch33. CerbellumCh34. Basal ganglia Section V: Homeostatic Systems Ch35. NociceptorsCh36. Central Pain Processing and Modulation Ch37. Autonomic Nervous SystemCh38. Forebrain Control of Homeostasis and Adaptation Section VI: Cortical Networks and Cognitive DomainsCh39. Emotion and Social CognitionCh40. Episodic Memory, Navigation, and Inner Thoughts Ch41. Language, Speech, and Semantic CognitionCh42. Cortical Executive Networks and High-level Behavioral and Cognitive Control