Dr Elizabeth J Price is a consultant rheumatologist who has a specific interest in Sjogren's Syndrome and runs a specialist Sjogren's clinic at the Great Western Hospital in Swindon. Her interest in Sjogren's dates from her Research Fellowship at The Kennedy Institute in London where she completed an MD thesis focusing on Sjogren's syndrome. She currently focuses on extraglandular manifestations of the disease and clinical research into SS and was the lead author and driving force behind the BSR Guidelines for the management of Sjogren's syndrome.Professor Anwar R Tappuni is a consultant in Oral Medicine with a special interest in the head and neck manifestations of Sjogren's syndrome. She leads a multidisciplinary clinic for Sjogren's syndrome patients at the Institute of Dentistry, Barts Health NHS Trust. Her team has produced impactful basic science and translational research, published in internationally renowned scientific journals. Professor Tappuni is the founder and director of the Doctorate in Clinical Dentistry in Oral Medicine programme at Queen Mary University of London. She was the lead author on the oral section of the NICE approved BSR Guidelines for the management of Sjogren's syndrome.

• Section 1: Introduction 1.1: Elizabeth J. Price and Anwar R. Tappuni: Introduction 1.2: Caroline Shiboski and Troy E. Daniels: Historical background, classification and diagnostic criteria 1.3: Simon Bowman: Epidemiology and genetics of Sjögren s Syndrome Section 2: Basic science 2.1: Onorina Berardicurti, Charlotte G. Smith, Roberto Giacomelli, Elizabeth J. Price, and Francesca Barone: Biomarkers in primary Sjögren sSyndrome 2.2: Aurélie Ambrosi, Albin Björk, and Marie Wahren-Herlenius: Autoantibodies and autoantigens in Sjögren s Syndrome 2.3: Saba Nayar, Serena Colafrancesco, and Francesca Barone: Stromal cells in Sjögren s Syndrome Section 3: Diagnostic investigations 3.1: Anwar R. Tappuni: Clinical assessment of salivary glands function 3.2: Benjamin Fisher: Biopsy gland biopsy procedure and histopathology 3.3: Ashok Adams: Imaging in Sjögren s Syndrome Section 4: Head and neck manifestations and clinical management 4.1: Emily Carter: Salivary glands manifestations and management 4.2: Anwar R. Tappuni: Oral manifestations and management 4.3: Jennifer Fuller and Shakeel Shahdad: Dental related disease Section 5: Ocular manifestations and management 5.1: Nicola Roper, Pasquale Aragona, Maurizio Rolando, and Francisco C Figueiredo: Ocular Manifestations of Sjögren s Syndrome 5.2: Nicola Roper, Pasquale Aragona, Maurizio Rolando, and Francisco C Figueiredo: A therapeutic strategy for Sjögren s Syndrome dry eye Section 6: Systemic manifestations 6.1: Thomas J Tull, Emma Benton, and David D Cruz: Cutaneous involvement and management of Sjögren s Syndrome 6.2: Elizabeth J. Price: Musculoskeletal disease - presentation and management 6.3: Rhys Evans and Stephen Walsh: Renal involvement in Primary Sjögren's Syndrome 6.4: Elizabeth J. Price: Gastrointestinal Disease in Sjögren s syndrome 6.5: Aravind Ganesh, Shane Lyons, and Gabriel Yiin: Neurological complications of Sjögren s Syndrome 6.6: Sara Carty: Cardiovascular and Lung Manifestations of Sjögren s Syndrome 6.7: Coziana Ciurtin and Su-Ann Yeoh: Haematological Manifestations of Sjögren s Syndrome 6.8: Coziana Ciurtin and Su-Ann Yeoh: Fatigue in Sjögren s Syndrome 6.9: Katie Hackett and Helen Cartner: Non-pharmacological interventions for the management of Fatigue and Constitutional Symptoms in Sjögren s Syndrome 6.1: Roberta Priori, Antonina Minniti, and Serena Colafrancesco: Gynaecologic and obstetric aspects in Sjögren s Syndrome 6.11: Saad Rassam: Sjögren s Syndrome Associated Lymphoma Section 7: Juvenile and young adult 7.1: William D. Renton, Elizabeth J. Price, and A.V. Ramanan: Juvenile and young adult onset Sjögren s Syndrome Section 8: Sjogren s mimics and overlaps 8.1: Nurhan Sutcliffe: Mimics of Sjögren s Syndrome 8.2: Nurhan Sutcliffe and Arabella Waller: Sjögren s Syndrome overlaps Section 9: Experimental treatments, emerging therapies and the future 9.1: Benjamin Fisher: Experimental therapies in primary Sjögren s Syndrome 9.2: Elizabeth J. Price and Alan Baer: Sjögren s Syndrome Summary of Clinical Management