Dr. Helen Lavretsky is a Professor of Psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA, a geriatric psychiatrist with the research interest in geriatric depression and caregiver stress, as well as complementary and alternative medicine and mind-body approaches to treatment and prevention of disorders in older adults. She is a recipient of the two Career Development awards from NIMH and other prestigious research awards. Her current research include clinical and translational studies of geriatric depression and caregiver stress, as well as complementary and alternative interventions for stress reduction in older adults.Dr. Sajatovic is Professor of Psychiatry at Case Western Reserve University School of Medicine in Cleveland, Ohio. She is a researcher, educator, and clinician who has devoted herself to the study and treatment of traditionally hard-to treat populations with serious mental illness. Dr. Sajatovic is Director of Geropsychiatry at University Hospitals Case Medical Center (UHCMC) and holds the Willard Brown Chair in Neurological Outcomes at UHCMC/Case Western Reserve University School of Medicine.Dr. Charles F. Reynolds III, M.D. is the UPMC Professor of Geriatric Psychiatry; and professor of neurology and neuroscience; Senior Associate Dean University of Pittsburgh School of Medicine; and professor of behavioral and community health sciences at the University of Pittsburgh Graduate School of Public Health. The recipient of a National Institute of Mental Health (NIMH) Research Scientist Award and a MERIT award for studies of "Maintenance Therapies in Late Life Depression," Dr. Reynolds has twice been named one of The Best Doctors in America and has received the Exemplary Psychiatrist Award from the National Alliance for the Mentally Ill.

This is an outstanding book covering an all too frequent but often unrecognized problem of late-life mood disorders. There has been enormous progress in understanding the neurobiology of these disorders and this book presents the latest information about this burgeoning research. Written and edited by internationally recognized leaders in the field, this is a welcome addition to geriatric psychiatry... This comprehensive book is an excellent guide to the current scientific knowledge about late-life mood disorders. All clinicians involved in the care of older adults should be familiar with the information it contains.

• Table of Contents ; Contributors ; Preface ; SECTION 1: Introduction to Late-Life Mood Disorders ; 1. A National Institute of Mental Health (NIMH) Perspective on Geriatric Mood Disorder Research ; Jovier D. Evans and George T. Niederehe ; 2. Research Priorities in Late Life Mood Disorders: An International Perspective ; Briony Dow, David Ames, Xiaoping Lin, Jean Tinney, and Betty Haralambous ; 3. Epidemiology of Late Life Mood Disorders: Rates, Measures and Populations ; Patricia Marino and Jo Anne Sirey ; 4. Public Health Burden of Late-Life Mood Disorders ; Jurgen Unutzer and Mijung Park ; 5. Late Onset Mood Disorders: ICDs and DSMs ; Roger Peele ; Section 2: Diagnosis and Comorbid Conditions ; 6. The Diagnosis and Treatment of Unipolar Depression in Late Life ; John Snowdon and Osvaldo P. Almeida ; 7. Bipolar Disorder ; Robert C. Young and Nahla A. Mahgoub ; 8. Non-Major Depression ; Ganesh Kulkarni, Ipsit V. Vahia, Thomas W. Meeks and Dilip V. Jeste ; 9. Anxious Depression: Application of a Unified Model of Emotional Disorders to Older Adults ; Andrew J. Petkus, Eric J. Lenze and Julie Loebach Wetherell ; 10. The Social Determinants of Depression in Older Adulthood ; Stephen E. Gilman, Hannah Carliner and Alex Cohen ; 11. Depression in Dementia ; Christopher M. Marano, Paul B. Rosenberg and Constantine G. Lyketsos ; 12. The Challenge of Suicide Prevention in Later Life ; Yeates Conwell and Alisa O'Riley ; 13. Bereavement and Complicated Grief in Older Adults ; Katherine M. Shear, Angela Ghesquiere and Michael S. Katzke ; 14. Current Issues in Informal Caregiving Research: Prevalence, Health Effects and Intervention Strategies ; Richard Schulz ; 15. Post-Stroke Depression and Vascular Depression ; Sarah Volk and David C. Steffens ; 16. Depression and Medical Illness in Late Life: Race, Resources, and Stress ; Briana Mezuk and Joseph J. Gallo ; 17. Comorbid Neurological Illness ; Dylan Wint and Jeffrey Cummings ; 18. Comorbid Substance Abuse ; David W. Oslin and Amy Helstrom ; 19. Comorbid Pain Disorders ; Jordan F. Karp and Jonathan McGovern ; 20. Bidirectional relationships between sleep, insomnia and depression ; Chiara Baglioni, Mathias Berger, and Dieter Riemann ; Section 3: Treatment and prevention ; 21. Use of adjunctive therapy in older depressed adults who are resistant to antidepressant treatment ; J. Craig Nelson ; 22. Psychotherapy ; Patricia A. Arean ; 23. ECT and Neuromodulation in the Treatment of Late-Life Mood Disorders ; William M. McDonald and Arshya Vahabzadeh ; 24. Complementary and Alternative Medicine (CAM) Approaches for Treatment and Prevention in Late-Life Mood Disorders ; David Merrill, Martha Payne and Helen Lavretsky ; 25. Prevention of Depression in Later Life: A Developmental Perspective ; Aartjan T.F. Beekman, Pim Cuipers and Filip Smit ; 26. Depression Medication Treatment Adherence in Later Life ; Kara Zivin, Janet Kavanagh, Susan M. Maixner, Jo Anne Sirey and Helen C. Kales ; Section 4: Care Delivery Systems ; 27. Depression in Long-term Care ; Christina Hui and David L. Sultzer ; 28. Late Life Depression in the Primary Care Setting: Toward a Patient-Centered Future ; Marsha Wittink, Paul Duberstein and Jeffrey M. Lyness ; 29. Depression in Older Adults Receiving Hospice Care ; Abhilash K. Desai, Daphne T. Lo and George T. Grossberg ; 30. Late Life Mood Disorders and Home-based Services and Interventions ; Kisha N. Bazelais, Yolonda R. Pickett and Martha L. Bruce ; 31. Novel Platforms for Care Delivery: Internet-based Interventions and Telepsychiatry ; Pim Cuipers, Heleen Riper and Aartjan Beekman ; Section 5: Neurobiology and Biomarkers ; 32. Structural Neuroimaging in Late Life Mood Disorders ; Sean J. Colloby and John T. O'Brien ; 33. Molecular Neuroimaging in Late Life Mood Disorders ; Anand Kumar, Olusola Ajilore, Brent Forester, Jaime Deseda, Matthew Woodward and Emma Rhodes ; 34. Functional Neuroimaging in Late Life Mood Disorders ; Meenal J. Patel, Howard J. Aizenstein and Gwenn S. Smith ; 35. Cognitive Biomarkers in Depression ; Oliver J. Robinson and Barbara J. Sahakian ; 36. Neuropathological Markers in Late-Life Depression ; Jose Javier Miguel-Hidalgo and Grazyna Rajkowska ; 37. Pharmacogenetics ; Greer M. Murphy, Jr. ; 38. Pharmacokinetics and Pharmacodynamics in Late Life ; Kristin L. Bigos, Robert R. Bies and Bruce G. Pollock ; 39. Psychoneuroimmunology of Depressive Disorders: Implications for Older Adults and Late-Life Depression ; Michael R. Irwin ; 40. The HPA Axis and Late Life Depression ; Keith Sudheimer, John Flournoy, Anda Gershon, Bevin Demuth, Alan Schatzberg and Ruth O'Hara ; 41. Clinical Prediction Models ; Wesley K. Thompson, Ji-in Choi and Stewart Anderson ; 42. Integration of Biological, Clinical and Psychosocial Predictors of Treatment Response Variability in Late-Life Depression ; Linda Garand, Ellen M. Whyte, Meryl A. Butters, Elizabeth R. Skidmore, Jordan F. Karp and Mary Amanda Dew ; 43. Conclusion ; Helen Lavretsky, Martha Sajatovic and Charles Reynolds III ; Index

Dr. Helen Lavretsky is a Professor of Psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA, a geriatric psychiatrist with the research interest in geriatric depression and caregiver stress, as well as complementary and alternative medicine and mind-body approaches to treatment and prevention of disorders in older adults. She is a recipient of the two Career Development awards from NIMH and other prestigious research awards. Her current research include clinical and translational studies of geriatric depression and caregiver stress, as well as complementary and alternative interventions for stress reduction in older adults.Dr. Sajatovic is Professor of Psychiatry at Case Western Reserve University School of Medicine in Cleveland, Ohio. She is a researcher, educator, and clinician who has devoted herself to the study and treatment of traditionally hard-to treat populations with serious mental illness. Dr. Sajatovic is Director of Geropsychiatry at University Hospitals Case Medical Center (UHCMC) and holds the Willard Brown Chair in Neurological Outcomes at UHCMC/Case Western Reserve University School of Medicine.Dr. Charles F. Reynolds III, M.D. is the UPMC Professor of Geriatric Psychiatry; and professor of neurology and neuroscience; Senior Associate Dean University of Pittsburgh School of Medicine; and professor of behavioral and community health sciences at the University of Pittsburgh Graduate School of Public Health. The recipient of a National Institute of Mental Health (NIMH) Research Scientist Award and a MERIT award for studies of "Maintenance Therapies in Late Life Depression," Dr. Reynolds has twice been named one of The Best Doctors in America and has received the Exemplary Psychiatrist Award from the National Alliance for the Mentally Ill.

This is an outstanding book covering an all too frequent but often unrecognized problem of late-life mood disorders. There has been enormous progress in understanding the neurobiology of these disorders and this book presents the latest information about this burgeoning research. Written and edited by internationally recognized leaders in the field, this is a welcome addition to geriatric psychiatry... This comprehensive book is an excellent guide to the current scientific knowledge about late-life mood disorders. All clinicians involved in the care of older adults should be familiar with the information it contains.

• Table of Contents ; Contributors ; Preface ; SECTION 1: Introduction to Late-Life Mood Disorders ; 1. A National Institute of Mental Health (NIMH) Perspective on Geriatric Mood Disorder Research ; Jovier D. Evans and George T. Niederehe ; 2. Research Priorities in Late Life Mood Disorders: An International Perspective ; Briony Dow, David Ames, Xiaoping Lin, Jean Tinney, and Betty Haralambous ; 3. Epidemiology of Late Life Mood Disorders: Rates, Measures and Populations ; Patricia Marino and Jo Anne Sirey ; 4. Public Health Burden of Late-Life Mood Disorders ; Jurgen Unutzer and Mijung Park ; 5. Late Onset Mood Disorders: ICDs and DSMs ; Roger Peele ; Section 2: Diagnosis and Comorbid Conditions ; 6. The Diagnosis and Treatment of Unipolar Depression in Late Life ; John Snowdon and Osvaldo P. Almeida ; 7. Bipolar Disorder ; Robert C. Young and Nahla A. Mahgoub ; 8. Non-Major Depression ; Ganesh Kulkarni, Ipsit V. Vahia, Thomas W. Meeks and Dilip V. Jeste ; 9. Anxious Depression: Application of a Unified Model of Emotional Disorders to Older Adults ; Andrew J. Petkus, Eric J. Lenze and Julie Loebach Wetherell ; 10. The Social Determinants of Depression in Older Adulthood ; Stephen E. Gilman, Hannah Carliner and Alex Cohen ; 11. Depression in Dementia ; Christopher M. Marano, Paul B. Rosenberg and Constantine G. Lyketsos ; 12. The Challenge of Suicide Prevention in Later Life ; Yeates Conwell and Alisa O'Riley ; 13. Bereavement and Complicated Grief in Older Adults ; Katherine M. Shear, Angela Ghesquiere and Michael S. Katzke ; 14. Current Issues in Informal Caregiving Research: Prevalence, Health Effects and Intervention Strategies ; Richard Schulz ; 15. Post-Stroke Depression and Vascular Depression ; Sarah Volk and David C. Steffens ; 16. Depression and Medical Illness in Late Life: Race, Resources, and Stress ; Briana Mezuk and Joseph J. Gallo ; 17. Comorbid Neurological Illness ; Dylan Wint and Jeffrey Cummings ; 18. Comorbid Substance Abuse ; David W. Oslin and Amy Helstrom ; 19. Comorbid Pain Disorders ; Jordan F. Karp and Jonathan McGovern ; 20. Bidirectional relationships between sleep, insomnia and depression ; Chiara Baglioni, Mathias Berger, and Dieter Riemann ; Section 3: Treatment and prevention ; 21. Use of adjunctive therapy in older depressed adults who are resistant to antidepressant treatment ; J. Craig Nelson ; 22. Psychotherapy ; Patricia A. Arean ; 23. ECT and Neuromodulation in the Treatment of Late-Life Mood Disorders ; William M. McDonald and Arshya Vahabzadeh ; 24. Complementary and Alternative Medicine (CAM) Approaches for Treatment and Prevention in Late-Life Mood Disorders ; David Merrill, Martha Payne and Helen Lavretsky ; 25. Prevention of Depression in Later Life: A Developmental Perspective ; Aartjan T.F. Beekman, Pim Cuipers and Filip Smit ; 26. Depression Medication Treatment Adherence in Later Life ; Kara Zivin, Janet Kavanagh, Susan M. Maixner, Jo Anne Sirey and Helen C. Kales ; Section 4: Care Delivery Systems ; 27. Depression in Long-term Care ; Christina Hui and David L. Sultzer ; 28. Late Life Depression in the Primary Care Setting: Toward a Patient-Centered Future ; Marsha Wittink, Paul Duberstein and Jeffrey M. Lyness ; 29. Depression in Older Adults Receiving Hospice Care ; Abhilash K. Desai, Daphne T. Lo and George T. Grossberg ; 30. Late Life Mood Disorders and Home-based Services and Interventions ; Kisha N. Bazelais, Yolonda R. Pickett and Martha L. Bruce ; 31. Novel Platforms for Care Delivery: Internet-based Interventions and Telepsychiatry ; Pim Cuipers, Heleen Riper and Aartjan Beekman ; Section 5: Neurobiology and Biomarkers ; 32. Structural Neuroimaging in Late Life Mood Disorders ; Sean J. Colloby and John T. O'Brien ; 33. Molecular Neuroimaging in Late Life Mood Disorders ; Anand Kumar, Olusola Ajilore, Brent Forester, Jaime Deseda, Matthew Woodward and Emma Rhodes ; 34. Functional Neuroimaging in Late Life Mood Disorders ; Meenal J. Patel, Howard J. Aizenstein and Gwenn S. Smith ; 35. Cognitive Biomarkers in Depression ; Oliver J. Robinson and Barbara J. Sahakian ; 36. Neuropathological Markers in Late-Life Depression ; Jose Javier Miguel-Hidalgo and Grazyna Rajkowska ; 37. Pharmacogenetics ; Greer M. Murphy, Jr. ; 38. Pharmacokinetics and Pharmacodynamics in Late Life ; Kristin L. Bigos, Robert R. Bies and Bruce G. Pollock ; 39. Psychoneuroimmunology of Depressive Disorders: Implications for Older Adults and Late-Life Depression ; Michael R. Irwin ; 40. The HPA Axis and Late Life Depression ; Keith Sudheimer, John Flournoy, Anda Gershon, Bevin Demuth, Alan Schatzberg and Ruth O'Hara ; 41. Clinical Prediction Models ; Wesley K. Thompson, Ji-in Choi and Stewart Anderson ; 42. Integration of Biological, Clinical and Psychosocial Predictors of Treatment Response Variability in Late-Life Depression ; Linda Garand, Ellen M. Whyte, Meryl A. Butters, Elizabeth R. Skidmore, Jordan F. Karp and Mary Amanda Dew ; 43. Conclusion ; Helen Lavretsky, Martha Sajatovic and Charles Reynolds III ; Index