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• 1 A Summary of Recent Updates on the Genetic Determinants of Depression2 Epigenetics of Major Depressive Disorder3 Brain Structural Abnormalities of Major Depressive Disorder4 Cognitive Deficits in Major Depression: From Mechanisms to Management5 Neuroendocrine Alterations in Major Depressive Disorder6 Inflammatory Abnormalities in Major Depressive Disorder7 Psychiatric Comorbidity in Major Depressive Disorder8 Pharmacological Treatment of Major Depressive Disorder9 Neurocircuitry-Based Treatments for Major Depressive Disorder10 Pharmacological and Nonpharmacological Treatment Effects on Functional Outcomes in Major Depressive Disorder11 Internet-Based/Technology-Based Interventions in Major Depressive Disorder12 Dysregulation of the Glutamatergic System in Major Depressive Disorder13 Glutamate Modulators in Major Depressive Disorder14 Depression in Children and Adolescents