Low-Grade Glioma, An Issue of Neurosurgery Clinics of North America

Dr. McKhann is Professor of Neurological Surgery at Columbia University Irving Medical Center/New York Presbyterian Hospital, where he is Director of Epilepsy Surgery and co-Director of the Division of Neuro-Oncology. He has over 25 years of experience at CUIMC/NYP, combining clinical skill and compassionate care to maximize patient outcomes. He is a member of both the Columbia P&S Virginia Apgar Academy of Medical Educators and the P&S Academy of Clinical Excellence. His areas of particular technical expertise include epilepsy surgery; awake and asleep brain mapping; brain tumor surgery, in particular low and high grade glioma and brain metastasis surgery; and stereotactic laser ablation for epilepsy and tumors. Dr. McKhann also works as a translational neuroscientist, directing the Epilepsy Neurophysiology Laboratory.

• 1. Epidemiology and Molecular Epidemiology 2. Molecular Pathogenesis 3. Alterations in the Brain Microenvironment in Diffusely Infiltrating Low Grade Glioma 4. Clinical Presentation, Natural History and Prognosis of Diffuse Low-Grade Gliomas 5. LGG Epilepsy 6. Mapping in Low Grade Glioma Surgery: Low and High Frequency Stimulation 7. Surgical Adjuncts to Increase EOR iMRI, Fluorescence, Raman Histology 8. Beyond Language: Mapping Cognition and Emotion 9. Evidence for Improving Outcome through Extent of Resection 10. EOR Versus Molecular Classification: What Matters When? 11. Chemotherapy Treatment and Trials in Low Grade Gliomas 12. Low-Grade Glioma Radiotherapy Treatment and Trials 13. Higher Order Surgical Questions for Diffuse Low-Grade Gliomas: Supramaximal Resection, Neuroplasticity and Screening 14. Building a Glioma Practice