"This seventh edition book represents a worthy update to this classic hepatobiliary surgery text. Since the previous version was published in 2017, the book has been updated to include numerous color photographs and illustrations. It covers all important conditions and procedures in benign and malignant diseases of the liver and biliary tree, as well as the pancreas." -©Doody’s Review Service, 2023, Peter Nau, MD, MS, FACS (University of Iowa Hospitals and Clinics) Doody's Score: 5 Stars!

• VOLUME 1Introduction: Hepatobiliary and Pancreatic Surgery: Historical PerspectivePART 1 Liver, Biliary, and Pancreatic Anatomy and Physiology1 Embryologic Development of the Liver, Biliary Tract, and Pancreas2 Surgical and Radiologic Anatomy of the Liver, Biliary Tract, and Pancreas3 Pancreatic Physiology and Functional Assessment4 Assessment of Hepatic Function: Implications for Perioperative Outcome and Recovery5 Liver Blood Flow: Physiology, Measurement, and Clinical Relevance6 Liver Regeneration: Mechanisms and Clinical Relevance7 Liver Fibrogenesis: Mechanisms and Clinical Relevance8 Bile Secretion and Pathophysiology of Biliary Tract Obstruction9A Molecular and cell Biology of Hepatopancreatobiliary Disease: Introduction and Basic Principles9B Molecular and Cell Biology of Liver Carcinogenesis and Hepatitis9C Advances in the Molecular Characterization of Liver Tumors9D Advances in the Molecular Characterization of Pancreatic Cancer and Pre-malignant Lesions9E Advances in the Molecular Characterization of Biliary Tract and Gallbladder Cancer10 Fundamentals of Liver and Pancreas Immunology11 Infections in Hepatic, Biliary, and Pancreatic SurgeryPART 2 Diagnostic Techniques12 Clinical Investigation of Hepatopancreatobiliary and Pancreatic Disease13 Cross-Sectional Imaging of Liver, Biliary, and Pancreatic Disease: Introduction and Basic Principles14 Imaging Features of Benign and Malignant Liver Tumors and Cysts15 Imaging Features of Metastatic Liver Cancer16 Imaging Features of Gallbladder and Biliary Tract Disease17 Imaging Features of Benign and Malignant Pancreatic Disease18 The Role of Nuclear Medicine in Diagnosis and Management of Hepatopancreatobiliary Diseases19 Emerging Techniques in Diagnostic Imaging20 Direct Cholangiography: Approaches, Techniques, and Current Role21 Diagnostic Angiography in Hepatobiliary and Pancreatic Disease: Indications22 Endoscopic Ultrasound of the Biliary Tract and Pancreas23 Image-Guided Liver Biopsy24 Intraoperative Diagnostic TechniquesPART 3 Anesthetic Management, Pre- and Postoperative Care25 Liver and Pancreatic Surgery: Intraoperative Management26 Nutrition and Perioperative Critical Care in the Hepatopancreatobiliary Surgery Patient27 Enhanced Recovery Programs in Hepatobiliary Surgery28 Postoperative Complications Requiring Intervention: Diagnosis and Management29 The Impact of Hepatobiliary Interventions on Health and Quality of Life and HealthPART 4 Techniques of Biliary Tract Intervention: Radiologic, Endoscopic, and Surgical30 Interventional Endoscopy for Biliary Tract Disease: Technical Aspects31 Radiologic Hepatobiliary Interventions32 Bile Duct Exploration and Biliary-Enteric AnastomosisPART 5 Biliary Tract DiseaseSECTION I Inflammatory, Infective, and CongenitalA Gallstones and Gallbladder33 The Natural History of Symptomatic and Asymptomatic Gallstones34 Cholecystitis35 Percutaneous Treatment of Gallbladder Disease36 Cholecystectomy Techniques and Postoperative Problems37A Stones in the Bile Duct: Clinical Features and Open Surgical Approaches and Techniques37B Stones in the Bile Duct: Minimally Invasive Surgical Approaches37C Stones in the Bile Duct: Endoscopic and Percutaneous Approaches38 Cholecystolithiasis and Stones in the Common Bile Duct: Which Approach and When?39 Intrahepatic Stone DiseaseB Biliary Stricture and Fistula40 Extrahepatic Biliary Atresia41 Primary Sclerosing Cholangitis42 Benign Biliary Strictures and Biliary FistulaeC Biliary Infection and Infestation43 Cholangitis44 Recurrent Pyogenic Cholangitis45 Biliary Parasitic DiseaseD Cystic Disease of the Biliary Tract46 Bile Duct Cysts in AdultsSECTION II NeoplasticA General47 Tumors of the Bile Ducts: Pathologic FeaturesB Benign Tumors48 Benign Tumors and Pseudotumors of the Biliary Tract49 Tumors of the Gallbladder50 Intrahepatic Cholangiocarcinoma51A Extrahepatic Biliary Tumors51B Perihilar Cholangiocarcinoma: Presurgical Management52 Interventional Techniques in Hilar and Intrahepatic Biliary StricturesPART 6 Pancreatic DiseaseSECTION I Inflammatory, Infective, and CongenitalA Congenital Disorders53 Congenital Disorders of the Pancreas: Surgical ConsiderationsB Pancreatitis54 Definition and Classification of Pancreatitis55 Etiology, Pathogenesis, and Diagnostic Assessment of Acute Pancreatitis56 Management of Acute Pancreatitis and Pancreatitis-Related Complications57 Etiology, Pathogenesis, and Diagnosis of Chronic Pancreatitis58 Management of Chronic Pancreatitis: Conservative, Endoscopic, SurgicalSECTION II NeoplasticA General59 Tumors of the Pancreas and AmpullaB Benign and Premalignant Tumors60 Cystic Neoplasms of the Pancreas: Epidemiology, Clinical Features, Assessment, and ManagementC Malignant Tumors61 Pancreatic Cancer: Epidemiology62 Pancreatic Cancer: Clinical Aspects, Assessment, and Management63 Duodenal Adenocarcinoma64 Pancreas as a Site of Metastatic CancerD Endocrine Tumors65 Pancreatic Neuroendocrine Tumors: Classification, Clinical Picture, Diagnosis, and Therapy66 Chemotherapy and Radiotherapy for Pancreatic Cancer: Adjuvant, Neoadjuvant, and Palliative67 Palliative Treatment of Pancreatic and Periampullary TumorsVOLUME 2PART 7 Hepatic DiseaseSECTION I Inflammatory, Infective, and CongenitalA Hepatitis68 Chronic Hepatitis: Epidemiology, Clinical Features, and Management69 Hepatic Steatosis, Steatohepatitis, and Chemotherapy-Related Liver InjuryB Liver Infection and Infestation70 Pyogenic Liver Abscess71 Amebiasis and Other Parasitic Infections72 Hydatid Disease of the LiverC Nonparasitic Liver Cysts73 Simple Cysts and Polycystic Liver Disease: Clinical and Radiographic Features and Surgical and Nonsurgical ManagementD Hepatic Cirrhosis, Portal Hypertension, and Hepatic Failure74 Cirrhosis and Portal Hypertension: Pathologic Aspects75 Nonhepatic Surgery in the Cirrhotic Patient76 Portal Hypertension in Children77 Management of Liver Failure78 Support of the Failing Liver79 Management of Ascites in Cirrhosis and Portal Hypertension80 Medical Management of Bleeding Varices: Primary and Secondary Prophylaxis for Variceal Bleeding81 Portal Hypertensive Bleeding: Acute Management82 Portal Hypertensive Bleeding: Operative Devascularization83 Portal Hypertensive Bleeding: the Role of Portosystemic Shunting84 Techniques of Portasystemic Shunting: Selective and Nonselective Shunts85 Transjugular Portosystemic Shunting (TIPS): Indications and Technique86 Budd-Chiari Syndrome and Veno-Occlusive DiseaseSECTION II NeoplasticA General87 Tumors of the Liver: Pathologic AspectsB Benign and Premalignant Tumors88A Benign Liver Lesions88B Cystic Hepatobiliary Neoplasia89 Hepatocellular Carcinoma90 Hepatic Metastasis from Colorectal Cancer91 Hepatic Metastasis from Neuroendocrine Cancers92 Hepatic Metastasis from Noncolorectal Nonneuroendocrine Tumors93 Hepatic Tumors in ChildhoodD Treatment: Nonresectional94A Hepatic Artery Embolization and Chemoembolization of Liver Tumors94B Radioembolization for Liver Tumors95 External Beam Radiotherapy for Liver Tumors96A Ablative Treatment of Liver Tumors: Overview96B Radiofrequency Ablation of Liver Tumors96C Microwave Ablation and Irreversible Electroporation of Liver Tumors96D Cryotherapy and Ethanol Injection97 Regional Chemotherapy for Liver Tumors98 Systemic Chemotherapy for Colorectal Liver Metastasis: Impact on Surgical Management99 Advances in Systemic Therapy for Hepatocellular Carcinoma100 Isolated Hepatic Perfusion for Unresectable Hepatic MetastasesE Treatment: Resection101A Hepatic Resection: General Considerations101B Hepatic Resection for Benign and Malignant Liver and Biliary Tract Disease: Indications and Outcomes102A Parenchymal Preservation in Hepatic Resectional Surgery: Rationale, Indications and Outcomes102B Segment-Oriented Anatomic Liver Resections: Indications and Outcomes102C Preoperative Portal Vein Embolization: Indications, Technique, and Results102D Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Indications and Outcomes103 Adjuncts to Hepatic Resection: From Ultrasound Guidance to New Oncologic and Technical HorizonsPART 8 Liver and Pancreas TransplantationSECTION I General104 Liver and Pancreas Transplantation ImmunobiologySECTION II Indications105 Liver Transplantation: Indications and General Considerations106 Liver Transplantation: Perioperative Anesthetic Considerations107 Liver Transplantation in Patients with Fulminant Hepatitis108A Liver Transplantation for Hepatocellular Carcinoma108B Liver Transplantation for Nonhepatocellular Malignant Disease109 Orthotopic Liver Transplantation: Standard Donation After Brain Death, Donation After Cardiac Death, and Live Donor - Indications and Outcomes110 Liver Transplantation in Children: Indications and Outcomes111 Early and Late Complications of Liver Transplantation112 Whole Organ Pancreas and Pancreatic Islet TransplantationPART 9 Hepatobiliary Injury and Hemorrhage113 Injuries to the Liver and Biliary Tract114 Pancreatic and Duodenal Injuries115 Aneurysm and Arteriovenous Fistula of the Liver and Pancreatic Vasculature116 Hemobilia and BilhemiaPART 10 Techniques of Pancreatic and Hepatic Resection and Transplantation117A Pancreaticoduodenectomy117B Distal and Central Pancreatectomy117C Total Pancreatectomy117D Transduodenal Resection of the Papilla of Vater118A Major Hepatectomy and Extended Hepatectomy118B Segmental Resection119A Hepatic Resection for Biliary Tract Cancer: Gallbladder Cancer119B Hilar Cholangiocarcinoma: Standard and Extended Resections of Perihilar Cholangiocarcinoma120 Hepatic Resection in Cirrhosis121 Resection Technique for Live Donor Transplantation122 Vascular Reconstruction Techniques in Hepato-Pancreato-Biliary (HPB) Surgery123 Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS): Techniques124 Ex Vivo and in Situ Hypothermic Hepatic Resection125 Techniques of Liver Replacement126 Techniques of Pancreas Transplantation127A Minimally Invasive Techniques in HPB Surgery: Laparoscopic and Robotic: General Principles and Considerations127B Minimally Invasive Distal and Central Pancreatectomy127C Minimally Invasive Pancreaticoduodenectomy127D Minimally Invasive Segmental Hepatic Resection127E Laparoscopic Major and Complex Liver Resection127F Robotic-Assisted Placement of Hepatic Arterial Infusion Pump128 Minimally Invasive Surgery Techniques in Transplantation

"This seventh edition book represents a worthy update to this classic hepatobiliary surgery text. Since the previous version was published in 2017, the book has been updated to include numerous color photographs and illustrations. It covers all important conditions and procedures in benign and malignant diseases of the liver and biliary tree, as well as the pancreas." -©Doody’s Review Service, 2023, Peter Nau, MD, MS, FACS (University of Iowa Hospitals and Clinics) Doody's Score: 5 Stars!

• VOLUME 1Introduction: Hepatobiliary and Pancreatic Surgery: Historical PerspectivePART 1 Liver, Biliary, and Pancreatic Anatomy and Physiology1 Embryologic Development of the Liver, Biliary Tract, and Pancreas2 Surgical and Radiologic Anatomy of the Liver, Biliary Tract, and Pancreas3 Pancreatic Physiology and Functional Assessment4 Assessment of Hepatic Function: Implications for Perioperative Outcome and Recovery5 Liver Blood Flow: Physiology, Measurement, and Clinical Relevance6 Liver Regeneration: Mechanisms and Clinical Relevance7 Liver Fibrogenesis: Mechanisms and Clinical Relevance8 Bile Secretion and Pathophysiology of Biliary Tract Obstruction9A Molecular and cell Biology of Hepatopancreatobiliary Disease: Introduction and Basic Principles9B Molecular and Cell Biology of Liver Carcinogenesis and Hepatitis9C Advances in the Molecular Characterization of Liver Tumors9D Advances in the Molecular Characterization of Pancreatic Cancer and Pre-malignant Lesions9E Advances in the Molecular Characterization of Biliary Tract and Gallbladder Cancer10 Fundamentals of Liver and Pancreas Immunology11 Infections in Hepatic, Biliary, and Pancreatic SurgeryPART 2 Diagnostic Techniques12 Clinical Investigation of Hepatopancreatobiliary and Pancreatic Disease13 Cross-Sectional Imaging of Liver, Biliary, and Pancreatic Disease: Introduction and Basic Principles14 Imaging Features of Benign and Malignant Liver Tumors and Cysts15 Imaging Features of Metastatic Liver Cancer16 Imaging Features of Gallbladder and Biliary Tract Disease17 Imaging Features of Benign and Malignant Pancreatic Disease18 The Role of Nuclear Medicine in Diagnosis and Management of Hepatopancreatobiliary Diseases19 Emerging Techniques in Diagnostic Imaging20 Direct Cholangiography: Approaches, Techniques, and Current Role21 Diagnostic Angiography in Hepatobiliary and Pancreatic Disease: Indications22 Endoscopic Ultrasound of the Biliary Tract and Pancreas23 Image-Guided Liver Biopsy24 Intraoperative Diagnostic TechniquesPART 3 Anesthetic Management, Pre- and Postoperative Care25 Liver and Pancreatic Surgery: Intraoperative Management26 Nutrition and Perioperative Critical Care in the Hepatopancreatobiliary Surgery Patient27 Enhanced Recovery Programs in Hepatobiliary Surgery28 Postoperative Complications Requiring Intervention: Diagnosis and Management29 The Impact of Hepatobiliary Interventions on Health and Quality of Life and HealthPART 4 Techniques of Biliary Tract Intervention: Radiologic, Endoscopic, and Surgical30 Interventional Endoscopy for Biliary Tract Disease: Technical Aspects31 Radiologic Hepatobiliary Interventions32 Bile Duct Exploration and Biliary-Enteric AnastomosisPART 5 Biliary Tract DiseaseSECTION I Inflammatory, Infective, and CongenitalA Gallstones and Gallbladder33 The Natural History of Symptomatic and Asymptomatic Gallstones34 Cholecystitis35 Percutaneous Treatment of Gallbladder Disease36 Cholecystectomy Techniques and Postoperative Problems37A Stones in the Bile Duct: Clinical Features and Open Surgical Approaches and Techniques37B Stones in the Bile Duct: Minimally Invasive Surgical Approaches37C Stones in the Bile Duct: Endoscopic and Percutaneous Approaches38 Cholecystolithiasis and Stones in the Common Bile Duct: Which Approach and When?39 Intrahepatic Stone DiseaseB Biliary Stricture and Fistula40 Extrahepatic Biliary Atresia41 Primary Sclerosing Cholangitis42 Benign Biliary Strictures and Biliary FistulaeC Biliary Infection and Infestation43 Cholangitis44 Recurrent Pyogenic Cholangitis45 Biliary Parasitic DiseaseD Cystic Disease of the Biliary Tract46 Bile Duct Cysts in AdultsSECTION II NeoplasticA General47 Tumors of the Bile Ducts: Pathologic FeaturesB Benign Tumors48 Benign Tumors and Pseudotumors of the Biliary Tract49 Tumors of the Gallbladder50 Intrahepatic Cholangiocarcinoma51A Extrahepatic Biliary Tumors51B Perihilar Cholangiocarcinoma: Presurgical Management52 Interventional Techniques in Hilar and Intrahepatic Biliary StricturesPART 6 Pancreatic DiseaseSECTION I Inflammatory, Infective, and CongenitalA Congenital Disorders53 Congenital Disorders of the Pancreas: Surgical ConsiderationsB Pancreatitis54 Definition and Classification of Pancreatitis55 Etiology, Pathogenesis, and Diagnostic Assessment of Acute Pancreatitis56 Management of Acute Pancreatitis and Pancreatitis-Related Complications57 Etiology, Pathogenesis, and Diagnosis of Chronic Pancreatitis58 Management of Chronic Pancreatitis: Conservative, Endoscopic, SurgicalSECTION II NeoplasticA General59 Tumors of the Pancreas and AmpullaB Benign and Premalignant Tumors60 Cystic Neoplasms of the Pancreas: Epidemiology, Clinical Features, Assessment, and ManagementC Malignant Tumors61 Pancreatic Cancer: Epidemiology62 Pancreatic Cancer: Clinical Aspects, Assessment, and Management63 Duodenal Adenocarcinoma64 Pancreas as a Site of Metastatic CancerD Endocrine Tumors65 Pancreatic Neuroendocrine Tumors: Classification, Clinical Picture, Diagnosis, and Therapy66 Chemotherapy and Radiotherapy for Pancreatic Cancer: Adjuvant, Neoadjuvant, and Palliative67 Palliative Treatment of Pancreatic and Periampullary TumorsVOLUME 2PART 7 Hepatic DiseaseSECTION I Inflammatory, Infective, and CongenitalA Hepatitis68 Chronic Hepatitis: Epidemiology, Clinical Features, and Management69 Hepatic Steatosis, Steatohepatitis, and Chemotherapy-Related Liver InjuryB Liver Infection and Infestation70 Pyogenic Liver Abscess71 Amebiasis and Other Parasitic Infections72 Hydatid Disease of the LiverC Nonparasitic Liver Cysts73 Simple Cysts and Polycystic Liver Disease: Clinical and Radiographic Features and Surgical and Nonsurgical ManagementD Hepatic Cirrhosis, Portal Hypertension, and Hepatic Failure74 Cirrhosis and Portal Hypertension: Pathologic Aspects75 Nonhepatic Surgery in the Cirrhotic Patient76 Portal Hypertension in Children77 Management of Liver Failure78 Support of the Failing Liver79 Management of Ascites in Cirrhosis and Portal Hypertension80 Medical Management of Bleeding Varices: Primary and Secondary Prophylaxis for Variceal Bleeding81 Portal Hypertensive Bleeding: Acute Management82 Portal Hypertensive Bleeding: Operative Devascularization83 Portal Hypertensive Bleeding: the Role of Portosystemic Shunting84 Techniques of Portasystemic Shunting: Selective and Nonselective Shunts85 Transjugular Portosystemic Shunting (TIPS): Indications and Technique86 Budd-Chiari Syndrome and Veno-Occlusive DiseaseSECTION II NeoplasticA General87 Tumors of the Liver: Pathologic AspectsB Benign and Premalignant Tumors88A Benign Liver Lesions88B Cystic Hepatobiliary Neoplasia89 Hepatocellular Carcinoma90 Hepatic Metastasis from Colorectal Cancer91 Hepatic Metastasis from Neuroendocrine Cancers92 Hepatic Metastasis from Noncolorectal Nonneuroendocrine Tumors93 Hepatic Tumors in ChildhoodD Treatment: Nonresectional94A Hepatic Artery Embolization and Chemoembolization of Liver Tumors94B Radioembolization for Liver Tumors95 External Beam Radiotherapy for Liver Tumors96A Ablative Treatment of Liver Tumors: Overview96B Radiofrequency Ablation of Liver Tumors96C Microwave Ablation and Irreversible Electroporation of Liver Tumors96D Cryotherapy and Ethanol Injection97 Regional Chemotherapy for Liver Tumors98 Systemic Chemotherapy for Colorectal Liver Metastasis: Impact on Surgical Management99 Advances in Systemic Therapy for Hepatocellular Carcinoma100 Isolated Hepatic Perfusion for Unresectable Hepatic MetastasesE Treatment: Resection101A Hepatic Resection: General Considerations101B Hepatic Resection for Benign and Malignant Liver and Biliary Tract Disease: Indications and Outcomes102A Parenchymal Preservation in Hepatic Resectional Surgery: Rationale, Indications and Outcomes102B Segment-Oriented Anatomic Liver Resections: Indications and Outcomes102C Preoperative Portal Vein Embolization: Indications, Technique, and Results102D Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Indications and Outcomes103 Adjuncts to Hepatic Resection: From Ultrasound Guidance to New Oncologic and Technical HorizonsPART 8 Liver and Pancreas TransplantationSECTION I General104 Liver and Pancreas Transplantation ImmunobiologySECTION II Indications105 Liver Transplantation: Indications and General Considerations106 Liver Transplantation: Perioperative Anesthetic Considerations107 Liver Transplantation in Patients with Fulminant Hepatitis108A Liver Transplantation for Hepatocellular Carcinoma108B Liver Transplantation for Nonhepatocellular Malignant Disease109 Orthotopic Liver Transplantation: Standard Donation After Brain Death, Donation After Cardiac Death, and Live Donor - Indications and Outcomes110 Liver Transplantation in Children: Indications and Outcomes111 Early and Late Complications of Liver Transplantation112 Whole Organ Pancreas and Pancreatic Islet TransplantationPART 9 Hepatobiliary Injury and Hemorrhage113 Injuries to the Liver and Biliary Tract114 Pancreatic and Duodenal Injuries115 Aneurysm and Arteriovenous Fistula of the Liver and Pancreatic Vasculature116 Hemobilia and BilhemiaPART 10 Techniques of Pancreatic and Hepatic Resection and Transplantation117A Pancreaticoduodenectomy117B Distal and Central Pancreatectomy117C Total Pancreatectomy117D Transduodenal Resection of the Papilla of Vater118A Major Hepatectomy and Extended Hepatectomy118B Segmental Resection119A Hepatic Resection for Biliary Tract Cancer: Gallbladder Cancer119B Hilar Cholangiocarcinoma: Standard and Extended Resections of Perihilar Cholangiocarcinoma120 Hepatic Resection in Cirrhosis121 Resection Technique for Live Donor Transplantation122 Vascular Reconstruction Techniques in Hepato-Pancreato-Biliary (HPB) Surgery123 Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS): Techniques124 Ex Vivo and in Situ Hypothermic Hepatic Resection125 Techniques of Liver Replacement126 Techniques of Pancreas Transplantation127A Minimally Invasive Techniques in HPB Surgery: Laparoscopic and Robotic: General Principles and Considerations127B Minimally Invasive Distal and Central Pancreatectomy127C Minimally Invasive Pancreaticoduodenectomy127D Minimally Invasive Segmental Hepatic Resection127E Laparoscopic Major and Complex Liver Resection127F Robotic-Assisted Placement of Hepatic Arterial Infusion Pump128 Minimally Invasive Surgery Techniques in Transplantation

"This seventh edition book represents a worthy update to this classic hepatobiliary surgery text. Since the previous version was published in 2017, the book has been updated to include numerous color photographs and illustrations. It covers all important conditions and procedures in benign and malignant diseases of the liver and biliary tree, as well as the pancreas." -©Doody’s Review Service, 2023, Peter Nau, MD, MS, FACS (University of Iowa Hospitals and Clinics) Doody's Score: 5 Stars!

• VOLUME 1Introduction: Hepatobiliary and Pancreatic Surgery: Historical PerspectivePART 1 Liver, Biliary, and Pancreatic Anatomy and Physiology1 Embryologic Development of the Liver, Biliary Tract, and Pancreas2 Surgical and Radiologic Anatomy of the Liver, Biliary Tract, and Pancreas3 Pancreatic Physiology and Functional Assessment4 Assessment of Hepatic Function: Implications for Perioperative Outcome and Recovery5 Liver Blood Flow: Physiology, Measurement, and Clinical Relevance6 Liver Regeneration: Mechanisms and Clinical Relevance7 Liver Fibrogenesis: Mechanisms and Clinical Relevance8 Bile Secretion and Pathophysiology of Biliary Tract Obstruction9A Molecular and cell Biology of Hepatopancreatobiliary Disease: Introduction and Basic Principles9B Molecular and Cell Biology of Liver Carcinogenesis and Hepatitis9C Advances in the Molecular Characterization of Liver Tumors9D Advances in the Molecular Characterization of Pancreatic Cancer and Pre-malignant Lesions9E Advances in the Molecular Characterization of Biliary Tract and Gallbladder Cancer10 Fundamentals of Liver and Pancreas Immunology11 Infections in Hepatic, Biliary, and Pancreatic SurgeryPART 2 Diagnostic Techniques12 Clinical Investigation of Hepatopancreatobiliary and Pancreatic Disease13 Cross-Sectional Imaging of Liver, Biliary, and Pancreatic Disease: Introduction and Basic Principles14 Imaging Features of Benign and Malignant Liver Tumors and Cysts15 Imaging Features of Metastatic Liver Cancer16 Imaging Features of Gallbladder and Biliary Tract Disease17 Imaging Features of Benign and Malignant Pancreatic Disease18 The Role of Nuclear Medicine in Diagnosis and Management of Hepatopancreatobiliary Diseases19 Emerging Techniques in Diagnostic Imaging20 Direct Cholangiography: Approaches, Techniques, and Current Role21 Diagnostic Angiography in Hepatobiliary and Pancreatic Disease: Indications22 Endoscopic Ultrasound of the Biliary Tract and Pancreas23 Image-Guided Liver Biopsy24 Intraoperative Diagnostic TechniquesPART 3 Anesthetic Management, Pre- and Postoperative Care25 Liver and Pancreatic Surgery: Intraoperative Management26 Nutrition and Perioperative Critical Care in the Hepatopancreatobiliary Surgery Patient27 Enhanced Recovery Programs in Hepatobiliary Surgery28 Postoperative Complications Requiring Intervention: Diagnosis and Management29 The Impact of Hepatobiliary Interventions on Health and Quality of Life and HealthPART 4 Techniques of Biliary Tract Intervention: Radiologic, Endoscopic, and Surgical30 Interventional Endoscopy for Biliary Tract Disease: Technical Aspects31 Radiologic Hepatobiliary Interventions32 Bile Duct Exploration and Biliary-Enteric AnastomosisPART 5 Biliary Tract DiseaseSECTION I Inflammatory, Infective, and CongenitalA Gallstones and Gallbladder33 The Natural History of Symptomatic and Asymptomatic Gallstones34 Cholecystitis35 Percutaneous Treatment of Gallbladder Disease36 Cholecystectomy Techniques and Postoperative Problems37A Stones in the Bile Duct: Clinical Features and Open Surgical Approaches and Techniques37B Stones in the Bile Duct: Minimally Invasive Surgical Approaches37C Stones in the Bile Duct: Endoscopic and Percutaneous Approaches38 Cholecystolithiasis and Stones in the Common Bile Duct: Which Approach and When?39 Intrahepatic Stone DiseaseB Biliary Stricture and Fistula40 Extrahepatic Biliary Atresia41 Primary Sclerosing Cholangitis42 Benign Biliary Strictures and Biliary FistulaeC Biliary Infection and Infestation43 Cholangitis44 Recurrent Pyogenic Cholangitis45 Biliary Parasitic DiseaseD Cystic Disease of the Biliary Tract46 Bile Duct Cysts in AdultsSECTION II NeoplasticA General47 Tumors of the Bile Ducts: Pathologic FeaturesB Benign Tumors48 Benign Tumors and Pseudotumors of the Biliary Tract49 Tumors of the Gallbladder50 Intrahepatic Cholangiocarcinoma51A Extrahepatic Biliary Tumors51B Perihilar Cholangiocarcinoma: Presurgical Management52 Interventional Techniques in Hilar and Intrahepatic Biliary StricturesPART 6 Pancreatic DiseaseSECTION I Inflammatory, Infective, and CongenitalA Congenital Disorders53 Congenital Disorders of the Pancreas: Surgical ConsiderationsB Pancreatitis54 Definition and Classification of Pancreatitis55 Etiology, Pathogenesis, and Diagnostic Assessment of Acute Pancreatitis56 Management of Acute Pancreatitis and Pancreatitis-Related Complications57 Etiology, Pathogenesis, and Diagnosis of Chronic Pancreatitis58 Management of Chronic Pancreatitis: Conservative, Endoscopic, SurgicalSECTION II NeoplasticA General59 Tumors of the Pancreas and AmpullaB Benign and Premalignant Tumors60 Cystic Neoplasms of the Pancreas: Epidemiology, Clinical Features, Assessment, and ManagementC Malignant Tumors61 Pancreatic Cancer: Epidemiology62 Pancreatic Cancer: Clinical Aspects, Assessment, and Management63 Duodenal Adenocarcinoma64 Pancreas as a Site of Metastatic CancerD Endocrine Tumors65 Pancreatic Neuroendocrine Tumors: Classification, Clinical Picture, Diagnosis, and Therapy66 Chemotherapy and Radiotherapy for Pancreatic Cancer: Adjuvant, Neoadjuvant, and Palliative67 Palliative Treatment of Pancreatic and Periampullary TumorsVOLUME 2PART 7 Hepatic DiseaseSECTION I Inflammatory, Infective, and CongenitalA Hepatitis68 Chronic Hepatitis: Epidemiology, Clinical Features, and Management69 Hepatic Steatosis, Steatohepatitis, and Chemotherapy-Related Liver InjuryB Liver Infection and Infestation70 Pyogenic Liver Abscess71 Amebiasis and Other Parasitic Infections72 Hydatid Disease of the LiverC Nonparasitic Liver Cysts73 Simple Cysts and Polycystic Liver Disease: Clinical and Radiographic Features and Surgical and Nonsurgical ManagementD Hepatic Cirrhosis, Portal Hypertension, and Hepatic Failure74 Cirrhosis and Portal Hypertension: Pathologic Aspects75 Nonhepatic Surgery in the Cirrhotic Patient76 Portal Hypertension in Children77 Management of Liver Failure78 Support of the Failing Liver79 Management of Ascites in Cirrhosis and Portal Hypertension80 Medical Management of Bleeding Varices: Primary and Secondary Prophylaxis for Variceal Bleeding81 Portal Hypertensive Bleeding: Acute Management82 Portal Hypertensive Bleeding: Operative Devascularization83 Portal Hypertensive Bleeding: the Role of Portosystemic Shunting84 Techniques of Portasystemic Shunting: Selective and Nonselective Shunts85 Transjugular Portosystemic Shunting (TIPS): Indications and Technique86 Budd-Chiari Syndrome and Veno-Occlusive DiseaseSECTION II NeoplasticA General87 Tumors of the Liver: Pathologic AspectsB Benign and Premalignant Tumors88A Benign Liver Lesions88B Cystic Hepatobiliary Neoplasia89 Hepatocellular Carcinoma90 Hepatic Metastasis from Colorectal Cancer91 Hepatic Metastasis from Neuroendocrine Cancers92 Hepatic Metastasis from Noncolorectal Nonneuroendocrine Tumors93 Hepatic Tumors in ChildhoodD Treatment: Nonresectional94A Hepatic Artery Embolization and Chemoembolization of Liver Tumors94B Radioembolization for Liver Tumors95 External Beam Radiotherapy for Liver Tumors96A Ablative Treatment of Liver Tumors: Overview96B Radiofrequency Ablation of Liver Tumors96C Microwave Ablation and Irreversible Electroporation of Liver Tumors96D Cryotherapy and Ethanol Injection97 Regional Chemotherapy for Liver Tumors98 Systemic Chemotherapy for Colorectal Liver Metastasis: Impact on Surgical Management99 Advances in Systemic Therapy for Hepatocellular Carcinoma100 Isolated Hepatic Perfusion for Unresectable Hepatic MetastasesE Treatment: Resection101A Hepatic Resection: General Considerations101B Hepatic Resection for Benign and Malignant Liver and Biliary Tract Disease: Indications and Outcomes102A Parenchymal Preservation in Hepatic Resectional Surgery: Rationale, Indications and Outcomes102B Segment-Oriented Anatomic Liver Resections: Indications and Outcomes102C Preoperative Portal Vein Embolization: Indications, Technique, and Results102D Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Indications and Outcomes103 Adjuncts to Hepatic Resection: From Ultrasound Guidance to New Oncologic and Technical HorizonsPART 8 Liver and Pancreas TransplantationSECTION I General104 Liver and Pancreas Transplantation ImmunobiologySECTION II Indications105 Liver Transplantation: Indications and General Considerations106 Liver Transplantation: Perioperative Anesthetic Considerations107 Liver Transplantation in Patients with Fulminant Hepatitis108A Liver Transplantation for Hepatocellular Carcinoma108B Liver Transplantation for Nonhepatocellular Malignant Disease109 Orthotopic Liver Transplantation: Standard Donation After Brain Death, Donation After Cardiac Death, and Live Donor - Indications and Outcomes110 Liver Transplantation in Children: Indications and Outcomes111 Early and Late Complications of Liver Transplantation112 Whole Organ Pancreas and Pancreatic Islet TransplantationPART 9 Hepatobiliary Injury and Hemorrhage113 Injuries to the Liver and Biliary Tract114 Pancreatic and Duodenal Injuries115 Aneurysm and Arteriovenous Fistula of the Liver and Pancreatic Vasculature116 Hemobilia and BilhemiaPART 10 Techniques of Pancreatic and Hepatic Resection and Transplantation117A Pancreaticoduodenectomy117B Distal and Central Pancreatectomy117C Total Pancreatectomy117D Transduodenal Resection of the Papilla of Vater118A Major Hepatectomy and Extended Hepatectomy118B Segmental Resection119A Hepatic Resection for Biliary Tract Cancer: Gallbladder Cancer119B Hilar Cholangiocarcinoma: Standard and Extended Resections of Perihilar Cholangiocarcinoma120 Hepatic Resection in Cirrhosis121 Resection Technique for Live Donor Transplantation122 Vascular Reconstruction Techniques in Hepato-Pancreato-Biliary (HPB) Surgery123 Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS): Techniques124 Ex Vivo and in Situ Hypothermic Hepatic Resection125 Techniques of Liver Replacement126 Techniques of Pancreas Transplantation127A Minimally Invasive Techniques in HPB Surgery: Laparoscopic and Robotic: General Principles and Considerations127B Minimally Invasive Distal and Central Pancreatectomy127C Minimally Invasive Pancreaticoduodenectomy127D Minimally Invasive Segmental Hepatic Resection127E Laparoscopic Major and Complex Liver Resection127F Robotic-Assisted Placement of Hepatic Arterial Infusion Pump128 Minimally Invasive Surgery Techniques in Transplantation