Associate Professor, DNP Program Coordinator, College of Nursing, Purdue University Northwest, Hammond, Indiana; Nurse Practitioner, Medical Staff, Northwest Medical Group Pulmonary and Critical Care Medicine, Valparaiso, Indiana; Hospitalist Nurse Practitioner, Medical Staff, TeamHealth, Valparaiso, Indiana.

• PART ONE: Central Concepts of Pathophysiology: Cells and TissuesUNIT I The Cell1 Cellular Biology2 Altered Cellular and Tissue Biology: Environmental Agents3 The Cellular Environment: Fluids and Electrolytes, Acids and BasesUNIT II Genes and Gene-Environment Interaction4 Genes and Genetic Diseases5 Genes, Environment-Lifestyle, and Common Diseases6 Epigenetics and DiseaseUNIT III Mechanisms of Self-Defense7 Innate Immunity: Inflammation and Wound Healing8 Adaptive Immunity9 Alterations in Immunity10 Infection11 Stress and DiseaseUNIT IV Cellular Proliferation: Cancer12 Cancer Biology13 Cancer Epidemiology14 Cancer in Children and AdolescentsUNIT V The Neurologic System15 Structure and Function of the Neurologic System16 Pain, Temperature Regulation, Sleep, and Sensory FunctionAlterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function18 Alterations of the Brain, Spinal Cord, and Peripheral Nerves19 Neurobiology of Schizophrenia, Mood Disorders, Anxiety Disorders, Posttraumatic Stress Disorder, and Obsessive-Compulsive Disorder20 Alterations of Neurologic Function in ChildrenUNIT VI The Endocrine System21 Mechanisms of Hormonal Regulation22 Alterations of Hormonal Regulation23 Obesity, Starvation, and Anorexia of AgingUNIT VII The Reproductive Systems24 Structure and Function of the Reproductive Systems25 Alterations of the Female Reproductive System26 Alterations of the Male Reproductive System27 Sexually Transmitted InfectionsUNIT VIII The Hematologic System28 Structure and Function of the Hematologic System29 Alterations of Hematologic Function30 Alterations of Hematologic Function in ChildrenUNIT IX The Cardiovascular and Lymphatic Systems31 Structure and Function of the Cardiovascular and Lymphatic Systems32 Alterations of Cardiovascular Function33 Alterations of Cardiovascular Function in ChildrenUNIT X The Pulmonary System34 Structure and Function of the Pulmonary System35 Alterations of Pulmonary Function36 Alterations of Pulmonary Function in ChildrenUNIT XI The Renal and Urologic Systems37 Structure and Function of the Renal and Urologic Systems38 Alterations of Renal and Urinary Tract Function39 Alterations of Renal and Urinary Tract Function in ChildrenUNIT XII The Digestive System40 Structure and Function of the Digestive System, 128541 Alterations of Digestive Function42 Alterations of Digestive Function in ChildrenUNIT XIII The Musculoskeletal System43 Structure and Function of the Musculoskeletal System44 Alterations of Musculoskeletal Function45 Alterations of Musculoskeletal Function in ChildrenUNIT XIV The Integumentary System46 Structure, Function, and Disorders of the Integument47 Alterations of the Integument in ChildrenUNIT XV Multiple Interacting Systems48 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults49 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

Associate Professor, DNP Program Coordinator, College of Nursing, Purdue University Northwest, Hammond, Indiana; Nurse Practitioner, Medical Staff, Northwest Medical Group Pulmonary and Critical Care Medicine, Valparaiso, Indiana; Hospitalist Nurse Practitioner, Medical Staff, TeamHealth, Valparaiso, Indiana.

• PART ONE: Central Concepts of Pathophysiology: Cells and TissuesUNIT I The Cell1 Cellular Biology2 Altered Cellular and Tissue Biology: Environmental Agents3 The Cellular Environment: Fluids and Electrolytes, Acids and BasesUNIT II Genes and Gene-Environment Interaction4 Genes and Genetic Diseases5 Genes, Environment-Lifestyle, and Common Diseases6 Epigenetics and DiseaseUNIT III Mechanisms of Self-Defense7 Innate Immunity: Inflammation and Wound Healing8 Adaptive Immunity9 Alterations in Immunity10 Infection11 Stress and DiseaseUNIT IV Cellular Proliferation: Cancer12 Cancer Biology13 Cancer Epidemiology14 Cancer in Children and AdolescentsUNIT V The Neurologic System15 Structure and Function of the Neurologic System16 Pain, Temperature Regulation, Sleep, and Sensory FunctionAlterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function18 Alterations of the Brain, Spinal Cord, and Peripheral Nerves19 Neurobiology of Schizophrenia, Mood Disorders, Anxiety Disorders, Posttraumatic Stress Disorder, and Obsessive-Compulsive Disorder20 Alterations of Neurologic Function in ChildrenUNIT VI The Endocrine System21 Mechanisms of Hormonal Regulation22 Alterations of Hormonal Regulation23 Obesity, Starvation, and Anorexia of AgingUNIT VII The Reproductive Systems24 Structure and Function of the Reproductive Systems25 Alterations of the Female Reproductive System26 Alterations of the Male Reproductive System27 Sexually Transmitted InfectionsUNIT VIII The Hematologic System28 Structure and Function of the Hematologic System29 Alterations of Hematologic Function30 Alterations of Hematologic Function in ChildrenUNIT IX The Cardiovascular and Lymphatic Systems31 Structure and Function of the Cardiovascular and Lymphatic Systems32 Alterations of Cardiovascular Function33 Alterations of Cardiovascular Function in ChildrenUNIT X The Pulmonary System34 Structure and Function of the Pulmonary System35 Alterations of Pulmonary Function36 Alterations of Pulmonary Function in ChildrenUNIT XI The Renal and Urologic Systems37 Structure and Function of the Renal and Urologic Systems38 Alterations of Renal and Urinary Tract Function39 Alterations of Renal and Urinary Tract Function in ChildrenUNIT XII The Digestive System40 Structure and Function of the Digestive System, 128541 Alterations of Digestive Function42 Alterations of Digestive Function in ChildrenUNIT XIII The Musculoskeletal System43 Structure and Function of the Musculoskeletal System44 Alterations of Musculoskeletal Function45 Alterations of Musculoskeletal Function in ChildrenUNIT XIV The Integumentary System46 Structure, Function, and Disorders of the Integument47 Alterations of the Integument in ChildrenUNIT XV Multiple Interacting Systems48 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults49 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

Associate Professor, DNP Program Coordinator, College of Nursing, Purdue University Northwest, Hammond, Indiana; Nurse Practitioner, Medical Staff, Northwest Medical Group Pulmonary and Critical Care Medicine, Valparaiso, Indiana; Hospitalist Nurse Practitioner, Medical Staff, TeamHealth, Valparaiso, Indiana.

• PART ONE: Central Concepts of Pathophysiology: Cells and TissuesUNIT I The Cell1 Cellular Biology2 Altered Cellular and Tissue Biology: Environmental Agents3 The Cellular Environment: Fluids and Electrolytes, Acids and BasesUNIT II Genes and Gene-Environment Interaction4 Genes and Genetic Diseases5 Genes, Environment-Lifestyle, and Common Diseases6 Epigenetics and DiseaseUNIT III Mechanisms of Self-Defense7 Innate Immunity: Inflammation and Wound Healing8 Adaptive Immunity9 Alterations in Immunity10 Infection11 Stress and DiseaseUNIT IV Cellular Proliferation: Cancer12 Cancer Biology13 Cancer Epidemiology14 Cancer in Children and AdolescentsUNIT V The Neurologic System15 Structure and Function of the Neurologic System16 Pain, Temperature Regulation, Sleep, and Sensory FunctionAlterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function18 Alterations of the Brain, Spinal Cord, and Peripheral Nerves19 Neurobiology of Schizophrenia, Mood Disorders, Anxiety Disorders, Posttraumatic Stress Disorder, and Obsessive-Compulsive Disorder20 Alterations of Neurologic Function in ChildrenUNIT VI The Endocrine System21 Mechanisms of Hormonal Regulation22 Alterations of Hormonal Regulation23 Obesity, Starvation, and Anorexia of AgingUNIT VII The Reproductive Systems24 Structure and Function of the Reproductive Systems25 Alterations of the Female Reproductive System26 Alterations of the Male Reproductive System27 Sexually Transmitted InfectionsUNIT VIII The Hematologic System28 Structure and Function of the Hematologic System29 Alterations of Hematologic Function30 Alterations of Hematologic Function in ChildrenUNIT IX The Cardiovascular and Lymphatic Systems31 Structure and Function of the Cardiovascular and Lymphatic Systems32 Alterations of Cardiovascular Function33 Alterations of Cardiovascular Function in ChildrenUNIT X The Pulmonary System34 Structure and Function of the Pulmonary System35 Alterations of Pulmonary Function36 Alterations of Pulmonary Function in ChildrenUNIT XI The Renal and Urologic Systems37 Structure and Function of the Renal and Urologic Systems38 Alterations of Renal and Urinary Tract Function39 Alterations of Renal and Urinary Tract Function in ChildrenUNIT XII The Digestive System40 Structure and Function of the Digestive System, 128541 Alterations of Digestive Function42 Alterations of Digestive Function in ChildrenUNIT XIII The Musculoskeletal System43 Structure and Function of the Musculoskeletal System44 Alterations of Musculoskeletal Function45 Alterations of Musculoskeletal Function in ChildrenUNIT XIV The Integumentary System46 Structure, Function, and Disorders of the Integument47 Alterations of the Integument in ChildrenUNIT XV Multiple Interacting Systems48 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults49 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children