Process Intensification in the Manufacturing of Biotherapeutics

Davide Moscatelli received his Laurea cum laude in Chemical Engineering at the Politecnico di Milano in 2002, and his PhD in Chemical Engineering in 2006. He is full professor of Applied Physical Chemistry at Politecnico di Milano and he collaborates with ETH Zurich since 2007. His main research interests are in the material synthesis for technological applications, with particular emphasis on polymer materials, nanomaterials and chemical compounds for biomedical and oil&gas applications. The general aim of his research is the development of new approaches to synthesize and functionalize innovative, efficient, and tunable smart materials. Davide Moscatelli is co-author of more than 120 papers on international journals and more than 10 patents. H-index: 26. Davide Moscatelli serves as lecturer of Petroleum Technologies and Refining Processes course at Politecnico di Milano. Davide Moscatelli supervised more than 100 Bachelor thesis students in Chemical Engineering, more than 100 Master thesis students in Chemical Engineering and Material Engineering, and more than 10 PhD theses in Industrial Chemistry and Chemical Engineering. He is ViceDirector of the PhD course of Industrial Chemistry and Chemical Engineering at Politecnico di Milano (http://phd.chem.polimi.it/staff/) and, since 2017, he is Member of the Faculty Committee for the strategic plan Polimi2040 at Politecnico di Milano. Davide Moscatelli is a member of the editorial board and advisory panel of several international scientific journals. He is co-founder of Captive Systems srl, a spin-off company of Politecnico di Milano active in use of smart nanomaterials for wastewater treatments. Mattia Sponchioni received his MSc cum laude in Chemical Engineering in 2015 and his PhD cum laude in Industrial Chemistry and Chemical Engineering in 2018, both at Politecnico di Milano. He is now working as a Research Associate at Politecnico di Milano, after having spent one year of Post-Doc at ETH Zürich.The main research interests of Mattia Sponchioni include the synthesis of thermo-responsive polymers and functional polymer nanoparticles for biomedical applications. During his career, Mattia gained expertise in the so-called controlled radical polymerization (CRP) techniques and in particular in the reversible addition-fragmentation chain transfer (RAFT) polymerization to impart highly controlled molecular architecture and chain length distribution to the polymers produced in his research. It is in this context that in 2017 Mattia spent six months as a visiting researcher at the University of Sheffield, in the group of Prof. Steven P. Armes, where he became expert in the RAFT-mediated polymerization-induced self-assembly (PISA) for the simultaneous synthesis of well-defined and amphiphilic block copolymers and their self-assembly into nanoparticles. Mattia Sponchioni is currently participant contact for the EU H2020 Marie-Curie innovative training network “Continuous Downstream Processing of Bioproducts” (https://www.researchgate.net/project/CODOBIO-Continuous-Downstream-Processing-of-Biologics) and teaching assistant of “Polymer Reaction Engineering” and “Applied Physical Chemistry” at Politecnico di Milano.

• 1. Evolution and design of continuous bioreactors for the production of biologics2. Continuous countercurrent chromatography for the downstream processing of bioproducts: A focus on flow-through technologies Application of multicolumn countercurrent solvent gradient purification to the polishing of therapeutic proteins3. Continuous precipitation technologies for the recovery of bioproducts4. Continuous Recovery and Purification of Bioproducts on the Basis of Adsorption Technology5. General Platform for Development of Integrated Continuous Downstream Processes6. Model-based digitalization of biopharmaceutical processes Fill-Finish: large scale manufacturing consideration