Feldman and Pike's Vitamin D

Prof. Hewison’s work focuses on different facets of vitamin D physiology, including classical skeletal effects and non-classical extra-skeletal effects. He has a particular interest in the interaction between vitamin D and the immune system, where antigen-presenting cells such as dendritic cells and macrophages synthesize active vitamin D (calcitriol) and also express the nuclear receptor for calcitriol (VDR). Vitamin D can therefore act as an endogenous regulator of both innate and adaptive immunity by enhancing antibacterial activity, and modulating antigen presentation and T lymphocyte function. Crucially these responses are highly dependent on the bioavailability of vitamin D, and Prof. Hewison has hypothesized that immune function is influenced by vitamin D status in humans. His group is using a variety of models to test this hypothesis including basic molecular and cell analyses, and vitamin D supplementation trials in human cohorts. A key objective of his work is to increase awareness of vitamin D-deficiency in the UK population. Roger Bouillon, MD, PhD, FRCP, biography Roger Bouillon is professor (emeritus since 2010) in endocrinology (internal medicine) at the University and University Hospital of the Catholic University of Leuven (K.U.Leuven) in Belgium. He is a member of the Royal Academy of Medicine (Belgium) and a Fellow of the Royal College of Physicians (London). He was a founding member and later President of the European Board of Endocrinology (UEMS 1988-2002). He was a member of several European Science Foundation Committees (Board member of the European Medical Research Council) and of the European Space Agency Life Science working group till 2012. He is past-president of the International Bone and Mineral Society (2011-13 ) and is co-organizer of the vitamin D workshop. He was vice president for research of the University of Leuven from 1995-2005. He is coauthor of more than 500 peer reviewed articles that generated about 26,000 ISI citations and a H index of 82. The topics of his research deal with (1) several aspects of diabetes an endocrinology in general but his main research focus deals with (2) hormonal aspects of bone and calcium homeostasis and this spans the spectrum of basic, translational and clinical research. (3) Vitamin D is a major research focus throughout his scientific career.Papers: Edward Giovannucci's research focuses on how nutritional, genetic, environmental and lifestyle factors relate to various malignancies, especially those of the prostate and large bowel. Much of his work is centered on large ongoing cohort studies, including the Nurses Health Study, the Health Professionals Follow-Up Study and the Physicians Health Study. A specific area of interest is the etiologic mechanisms underlying the relation between modifiable factors and cancer risk. His work has included the study of how nutrition and other lifestyle factors impact on cancer risk and progression by influencing levels of insulin, insulin-like growth factors, vitamin D metabolites, and steroid hormones. Another area of interest is how nutrients may interact with genetic susceptibilities in determining an individual's risk. David Goltzman is Professor in the Departments of Medicine and Physiology of McGill University, Director of the McGill Centre for Bone and Periodontal Research, and Senior Physician in the Endocrine Division of the Department of Medicine of the McGill University Health Centre. His research has focused on the hormonal regulation of mineral and skeletal homeostasis, and he has made many important contributions to our knowledge of parathyroid hormone (PTH), PTH related peptide and vitamin D, which have had major impact on our understanding of a variety of metabolic bone diseases. He is also principal investigator of the Canadian Multicentre Osteoporosis Study (CaMos) which examines the demographics, development, risk factors and outcomes of osteoporosis. Dr. Goltzman has received various honours and awards, including the Aurbach Award of the US Endocrine Society, the Raisz Award of the American Society for Bone and Mineral Research (ASBMR), fellowship in the Royal Society of Canada and in the Canadian Academy of Health Sciences, the Order of Canada, an honorary professorship from Nanjing University and the degree of Doctor Honoris Causa from the University of Athens. He is a past President of the ASBMR, the Canadian Society of Clinical Investigation and the Canadian Society of Endocrinology and Metabolism. Dr. Mayer is Senior Scientist and Associate Lecturer at the Department of Biochemistry, University of Wisconsin, USA. His research interest includes the characterization of several key genes modulated by the vitamin D hormone and the vitamin D receptor. These genes range from bone remodeling factors to calcium transport mechanisms in the intestine. Dr. Welsh is a preeminent researcher on the role of Vitamin D in breast cancer and studies nuclear receptors in health and disease. The Welsh lab has particular expertise in studying the role of dietary-derived ligands for nuclear receptors in cancer prevention and therapy. Recent projects have focused on the molecular mechanisms by which vitamin D and its nuclear receptor modulate adiposity, stem cell function and cancer development.Dr. Welsh recently received funding from the National Cancer Institute to examine the impact of vitamin D and other natural products on hyaluronic acid metabolism and signaling in triple negative breast cancer.

*4 stars* "...an encyclopedically extensive comprehensive reference on our current state of knowledge and contemporary research into this intriguingly complex micronutrient.... [F]eatures expanded content and increased emphasis on the role vitamin D plays in human health, including insights revealed by the Covid pandemic. The book represents a rich and extensive reference for anyone interested in the biology, metabolism, mechanism of action, and pathology of vitamin D,... the product of over 200 contributors.... A robust collection of informative and well-constructed figures and tables, including many that present primary research data that add depth to the presentation, complements the text. [I]mpressively comprehensive in scope, well organized, and clearly written.... [A] truly encyclopedic resource regarding all things vitamin D. As such, ...the essential reference on this important micronutrient." --©Doody’s Review Service, 2024, Peter J. Kennelly, PhD (Virginia Tech)

• 1. Book introduction: Major trends in vitamin D research;2. Evolution of human skin pigmentation and vitamin D;3. Photobiology of vitamin D;4. The activating enzymes of vitamin D metabolism (25- and 1α-hydroxylases);5. CYP24A1: structure, function, and physiological role;6. Alternative pathways for vitamin D metabolism;7. Vitamin Debinding protein;8. Regulation of renal vitamin D metabolism;9. Regulation of extra-renal synthesis of 1,25(OH)2D;10. Structural basis for ligand activity in vitamin D receptor;11. Genome-wide perspectives on vitamin D receptor actions;12. Vitamin D, chromatin, and epigenetics;13. The diverse genomic mechanisms of action of the vitamin D receptor;14. Vitamin D and microRNAs;15. Pathway based-analysis of transcriptomic data from vitamin D studies16. Vitamin D and the kidney;17. Vitamin D and the calcium-sensing receptor;18. Regulation of intestinal calcium and phosphate absorption by vitamin D;19. Vitamin D and FGF23;20. Osteoclastogenesis and vitamin D;21. Vitamin D activity in osteoblasts and osteocytes;22. Cartilage;23. Vitamin D and bone: an integrated approach;24. Vitamin D in dentoalveolar and oral health;25. Role of vitamin D in skin and hair biology;26. Vitamin D and the cardiovascular system;27. Vitamin D, brain development and function;28. Vitamin D, VDR, and adipose tissue: focus on cellular mechanisms;29. Vitamin D and skeletal muscle;30. Understanding vitamin D from mouse knockout models;31. Pharmacology and pharmacokinetics of vitamin D;32. Vitamin D as a modifier of genomic function and phenotypic expression during pregnancy;33. The role of vitamin D physiology in regulating calcium and bone metabolism in mother and child: pregnancy, lactation, postweaning, fetus, and neonate;34. Vitamin D and the placenta;35. Consequences of perinatal vitamin D deficiency on later bone health;36. Adolescence and acquisition of peak bone mass;37. The role of vitamin D in orthopedic surgery;38. Vitamin D and muscle performance in athletes and older adults;39. Role in reproductive biology and dysfunction in women;40. Vitamin D, reproductive endocrinology, and male reproductive organ function in health and disease;41. Vitamin D and the renineangiotensin system;42. Vitamin D: presence and function in the eye;43. Adult vitamin D deficiency and adverse brain outcomes44. Vitamin D and the lung;45. Design and synthesis of vitamin D analogs;46. Structure function relationships of VDR ligands;47. Modulating vitamin D receptore coregulator binding with small molecules;48. Mass spectrometry assays of vitamin D metabolites;49. Measurement and quality assessment of total and free 25-hydroxyvitamin D;50. Vitamin D tissue distribution by mass spectrometry imaging;Index for Volume 1