Firestein & Kelley's Textbook of Rheumatology, 2-Volume Set

Gary Firestein, MD, is a board-certified rheumatologist who diagnoses and treats patients with autoimmune conditions as well as diseases of the joints, muscles and bones. A professor at UC San Diego School of Medicine, Dr. Firestein is distinguished for his research and serves as director of the Altman Clinical and Translational Research Institute and the senior associate vice chancellor for health sciences. Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis. Dr. Firestein is the recipient of many awards and honors, including the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for his contributions to rheumatology; the Arthritis Foundation Lee C. Howley Sr. Prize for Arthritis Research; and the American College of Rheumatology Distinguished Investigator Award. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He has served as an editor for the Textbook of Rheumatology for since the 7th edition (2004). Iain McInnes is Director of the Institute of Infection, Immunity and Inflammation at the University of Glasgow, UK. He has extensive experience in leading multicenter programs nationally and internationally. He is Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Program, Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery program (PROMISERA), and chief investigator of numerous global phase II and III clinical trials of novel immune therapies. He has served as member or chair of numerous national grant-funding panels and as chair of several European League Against Rheumatism (EULAR) scientific committees - he is now Treasurer and President Elect of EULAR serving on its Steering Committee. He is formerly Chairman of the Foundation for European Rheumatology Research (Foreum) Scientific Committee and leads the EULAR-supported European Roadmap Program that is defining the research agenda for rheumatology for the next decade. Gary Koretzky, MD, PhD is Professor of Medicine at Weill Cornell Graduate School. Dr. Koretzky's research aims to better understand the signal transduction events that occur following engagement of the T cell antigen receptor. He has been continuously funded by the National Institutes of Health since establishing his independent research group, as the laboratory has expanded its interests to study more globally the molecular events important for immune cell development, differentiation and function. Dr. Koretzky has published more than 200 research articles. He is a past President of the American Society of Clinical Investigation (2000) and Councilor of the Association of American Physicians (2008-2012), is a Fellow of the American Association for the Advancement of Science (2004), a member of the Institute of Medicine of the National Academies (2008), a Fellow of the American Academy of Arts & Sciences (2012) and serves as the Editor-in-Chief of Immunological Reviews (2002-present). Dr. Mikuls is a rheumatologist and epidemiologist with research interests focused on the epidemiology, pathogenesis, and outcomes of rheumatoid arthritis (RA) and gout. He is actively engaged in clinical/translational research activities and has received research funding from the NIH, U.S. Department of Defense, Veterans Affairs, the Rheumatology Research Foundation, and industry. He has extensive experience conducting multi-center / multidisciplinary trials, serving as the Principal Investigator (PI) for the multicenter Veterans Affairs Rheumatoid Arthritis (VARA) registry since its inception in 2003. He has served on multiple national study sections including those convened by the NIH, VA, and the Rheumatology Research Foundation. He previously chaired the American College of Rheumatology (ACR) Subcommittee for Practice Guidelines, served on the US FDA's Arthritis Advisory Committee, and was the Lead Editor for the textbook A Color Handbook - Rheumatology. Tuhina Neogi is a rheumatologist and epidemiologist whose research has focused primarily on risk factors for knee osteoarthritis and gout, pain mechanisms in knee osteoarthritis, as well as methodologic issues of relevance for rheumatic diseases. Dr. Neogi has had continuous peer-reviewed foundation and NIH funding since 2003 and has over 250 peer-reviewed publications to date. She is a past chair of the FDA Arthritis Advisory Committee, serve(d) on the boards of two international societies: Osteoarthritis Research Society International (OARSI) and Gout, Hyperuricemia, and Crystal-Associated Diseases Network (G-CAN), and on committees for the American College of Rheumatology (ACR) and International Association for the Study Pain (IASP), among others. Her work has been recognized with the prestigious 2014 ACR Henry Kunkel Young Investigator Award for outstanding and promising independent contributions to rheumatology research and she has also engaged in developing new classification criteria for a number of rheumatic diseases. James R. O'Dell, MD is the Stokes Shackleford Professor of Internal Medicine, Vice-Chairman of Internal Medicine and Chief of the Division of Rheumatology at the University of Nebraska Medical Center (UNMC) in Omaha. Dr. O'Dell founded and has directed the Rheumatoid Arthritis Investigational Network (RAIN) for the last 25 years. Dr. O'Dell is the PI of the large multinational RA research study based at the VA through their cooperative studies program. Dr. O'Dell has published extensively, mostly in the area of rheumatoid arthritis. He has presented frequently at national and international meetings and has more than 100 published articles in top-level rheumatology journals. He has served on numerous American College of Rheumatology (ACR) committees over the last 20 years, including time on both the ACR and REF BOD, as well as a two-year term as President of the Research and Education Foundation of the ACR and was President of the College (2011-2012). Additionally, he is Editor-in-Chief of Up To Date for Rheumatology.

5 Stars! "...encompasses everything needed for professionals in rheumatology, providing an easy overview where topics can be readily found. The illustrations are helpful, and the videos included with the book enhance the learning experience. [It] is exceptionally comprehensive, allowing for thorough review of any topic necessary to fully grasp the latest updates in diagnoses and treatments, as well as the fundamental principles of rheumatology. The preface is particularly noteworthy, as it provides a clear overview of the book’s organization and offers a glimpse into the meticulous effort put into each chapter. The overall tone is informative and highly appreciated, ensuring that the audience is well-prepared to delve into the content. It covers a complete list of topics essential for understanding and treating rheumatology conditions, including pathophysiology, clinical manifestations, and treatment options. The book's comprehensive structure offers in-depth coverage across multiple dimensions, with detailed illustrations, high-quality artwork, and informative photographs supporting visual clarity." Review by Joseph Yusin, MD (VA Greater Los Angeles Healthcare System), ©Doody's Review Service 2025. Doody's Score: 100, 5 Stars!

• PART 1 Structure and Function of Bone, Joints, and Connective Tissue1 Developmental Biology, Organization, and Function of the Synovial Joints2 Synovium3 Cartilage and Chondrocytes4 Development and Biology of Bone5 Muscle Anatomy, Physiology, and Biochemistry6 Biomechanics7 Regenerative Medicine and Tissue Engineering8 Proteinases and Matrix DegradationPART 2 Cells Involved in Autoimmune Diseases and Inflammation9 Dendritic Cells10 Mononuclear Phagocytes11 Neutrophils12 T Lymphocytes13 B Cells14 Fibroblasts andFibroblast-like Synoviocytes15 Mast Cells and Basophils16 Innate Lymphoid Cells and Natural Killer Cells17 Platelets and MegakaryocytesPART 3 Effector Mechanisms in Autoimmunity and Inflammation 18 Principles of Signaling19 Innate Immunity20 Adaptive Immunity21 Immune Tolerance and Autoimmunity22 Pre-clinical Autoimmunity23 The Microbiome in Rheumatic Diseases24 Genetics of Rheumatic Diseases25 Epigenetics of Rheumatic Diseases26 Complement System27 Prostaglandins, Leukotrienes, and Related Compounds28 Angiogenesis29 Cytokines and Chemokines30 Neuronal Mechanisms of Pain and InflammationPART 4 Broad Issues in the Approach to Rheumatic Disease31 Clinical Research Methods in the Rheumatic Diseases32 Epidemiology and Impact of Rheumatic Diseases33 Assessment of Health Outcomes34 Biomarkers in Rheumatology35 Occupational, Environmental, and Recreational Musculoskeletal Disorders36 Cardiovascular Risk in Inflammatory Rheumatic Disease37 Cancer Risk in Rheumatic Diseases38 Occupational Therapy, Physical Therapy, and Rehabilitation39 General Principles of Pregnancy and Rheumatic Disease: Pre-pregnancy AssessmentPART 5 Evaluation of Generalized and Localized Symptoms40 History and Physical Examination of the Musculoskeletal System41 Ultrasound in Rheumatology42 Evaluation of Monoarticular and Polyarticular Arthritis43 Skin and Rheumatic Diseases44 The Eye and Rheumatic DiseasesPART 6 Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain45 Neck Pain46 Shoulder Pain47 Low Back Pain48 Hip and Knee Pain49 Foot and Ankle Pain50 Hand and Wrist Pain51 Temporomandibular Joint Disorders52 FibromyalgiaPART 7 Diagnostic Tests and Procedures in Rheumatic Diseases53 Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology54 Arthrocentesis and Injection of Joints and Soft Tissues55 Anti-nuclear Antibodies56 Autoantibodies in Rheumatoid Arthritis57 Acute Phase Reactants58 Imaging in Rheumatic DiseasesPART 8 Pharmacology of Anti-rheumatic Drugs59 Therapeutic Targeting of Prostanoids60 Glucocorticoid Therapy61 Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies62 Immunosuppressive Drugs63 Anti-cytokine Biologics64 Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics65 Janus Kinase and Other Intra-cellular Targets66 Urate-Lowering Therapy67 Bisphosphonates68 Analgesic Agents in Rheumatic Disease69 Nutrition and Rheumatic DiseasesPART 9 Rheumatoid Arthritis and Sjögren’s Syndrome70 Etiology of Rheumatoid Arthritis71 Pathogenesis of Rheumatoid Arthritis72 Clinical Features of Rheumatoid Arthritis73 Treatment of Rheumatoid Arthritis74 Sjögren’s SyndromePART 10 Spondyloarthritis75 Classification and Epidemiology of Spondyloarthritis76 Axial Spondyloarthritis77 Reactive Arthritis78 Psoriatic Arthritis79 Inflammatory Bowel Disease-Associated Arthritis and Other Enteropathic ArthropathiesPART 11 Systemic Lupus Erythematosus and Related Syndromes80 Etiology and Pathogenesis of Systemic Lupus Erythematosus81 Clinical Features of Systemic Lupus Erythematosus82 Treatment of Systemic Lupus Erythematosus83 Antiphospholipid SyndromePART 12 Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes84 Etiology and Pathogenesis of Systemic Sclerosis85 Clinical Features and Treatment of Scleroderma86 Inflammatory Diseases of Muscle and Other Myopathies87 Overlap SyndromesPART 13 Vasculitis88 Classification and Epidemiology of Systemic Vasculitis89 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis90 Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis91 Polyarteritis Nodosa92 Immune Complex-Mediated Small Vessel Vasculitis93 Primary Central Nervous System Vasculitis94 Behçet’s DiseasePART 14 Crystal-Induced and Inflammasome-Mediated Inflammation95 Pathogenesis of Inflammasome-Mediated Diseases96 Etiology and Pathogenesis of Hyperuricemia and Gout97 Clinical Features and Treatment of Gout98 Calcium Crystal Disease: Calcium Pyrophosphate Deposition Disease and Basic Calcium Phosphate-Associated Syndromes99 Familial and Nonfamilial Autoinflammatory SyndromesPART 15 Cartilage, Bone, and Heritable Connective Tissue Disorders100 Etiology and Pathogenesis of Osteoarthritis101 Clinical Features of Osteoarthritis102 Treatment of Osteoarthritis103 Metabolic Bone Disease104 Proliferative Bone Diseases105 Osteonecrosis106 Relapsing Polychondritis107 Heritable Diseases of Connective TissuesPART 16 Rheumatic Diseases of Childhood108 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis109 Clinical Features and Treatment of Juvenile Idiopathic Arthritis110 Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus111 Juvenile Dermatomyositis, Scleroderma, and VasculitisPART 17 Infections and Rheumatic Disease112 Bacterial Arthritis113 Lyme Disease114 Mycobacterial Infections of Bones and Joints115 Fungal Infections of Bones and Joints116 Rheumatic Manifestations of Human Immunodeficiency Virus Infection117 Viral Arthritis118 Rheumatic Fever and Post-streptococcal Arthritis119 COVID-19 and Rheumatic Disease120 Vaccination in Rheumatic DiseasePART 18 Arthritis Accompanying Systemic Disease121 Amyloidosis122 Sarcoidosis123 Hemochromatosis124 Hemophilic Arthropathy125 Rheumatic Manifestations of Hemoglobinopathies126 IgG4-Related Disease127 Arthritis Accompanying Endocrine and Metabolic Disorders128 Rheumatic Paraneoplastic Syndromes and Malignancies With Rheumatic Manifestations129 Tumors and Tumor-like Lesions of Joints and Related Structures130 Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer