An Integrated Guide to Human Drug Metabolism

Dr Mark Ashton started his career in the pharmaceutical industry in 2002 working in both medicinal chemistry and process chemistry departments. In 2010, Mark joined the School of Pharmacy at Sunderland University as a Senior Lecturer in Medicinal Chemistry where he taught across a range of both undergraduate and postgraduate chemistry-based degree programmes, including all four stages of the MPharm degree. In 2017 Mark joined the School of Pharmacy at Newcastle University as a lecturer in Medicinal Chemistry where he has overseen the redevelopment of the chemistry strand of the MPharm degree to improve the integration between the science and practice aspects of the degree. His research interests include the development of new antiviral agents and synthetic biology. Paul Groundwater gained his B.Sc. Chemistry and Ph.D. degrees from the University of Edinburgh. He was a post-doctoral fellow at the Australian National University, Canberra then joined the Cancer Research Campaign Experimental Chemotherapy Research Group, Aston University, UK. He was appointed to a Lectureship in the Department of Chemistry, Cardiff University and then was appointed to a Readership in Organic Chemistry in the Institute of Pharmacy and Chemistry at the University of Sunderland and was promoted to Professor, in the Sunderland Pharmacy School, in 2001. In 2009 he moved to the University of Sydney, where he is Prof. of Medicinal Chemistry and has served as Associate Dean (Learning and Teaching) in the Faculty of Pharmacy. He has published more than 100 refereed articles, four books and 3 patents and has been a Guest Professor in the School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P.R. China. Dr Stocker is a Senior Lecturer at the School of Pharmacy, Sydney University. She is also an Honorary Senior Hospital Scientist in the Department of Clinical Pharmacology and Toxicology at St Vincent’s Hospital, Sydney, an Adjunct Senior Lecturer of the St Vincent’s Clinical School, University of New South Wales and an Honorary Scientist at the Garvan Medical Research Institute. Dr Stocker is the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Australasian Student representative. Her research program involves clinical and experimental pharmacology, ethnopharmacology, pharmacogenomics, therapeutic drug monitoring, pharmacometrics and qualitative research on the impact of intrinsic and extrinsic factors on drug disposition, efficacy and safety. Her research focuses on understanding variability in response to medicines and how this can be managed to optimise patient care. Dr Stocker is the author of over 40 scientific articles published in peer-reviewed journals. Dr. Adam Todd is as an academic pharmacist (registrant of the General Pharmaceutical Council and a Fellow of the Royal Pharmaceutical Society) and has experience of working in clinical practice for the last 15 years – across both primary care and hospital-based settings. To complement Adam’s clinical experience of pharmacy, he also holds a PhD in medicinal chemistry and is therefore able to integrate aspects of fundamental science with pharmacy practice – a unique selling point of our proposed book. Adam is an experienced educator, and currently holds an academic position at the Newcastle University where he is a Reader in Pharmaceutical Public Health and is helping to establish a new innovative pharmacy program. Adam has published more than 80 peer reviewed research papers, two textbooks, and one international patent.

"...presents various aspects of human drug metabolism, detailing how medicines are metabolized and the factors that influence drug clearance. Its purpose is to lay a strong foundation in clinical pharmacology, including human drug metabolism, as a critical requirement of rational therapeutics, which supports the safe and effective use of medicines.... The book presents many real-world examples and is supported by many color figures, schemes and tables of an excellent quality that support and enhance the text, increasing its accessibility to health professionals, irrespective of their training level.... [It] is an up to date, condensed, yet comprehensive, guide to human drug metabolism, written in a concise, focused style,... using excellent graphics, schemes, and diagrams the book succeeds in making difficult concepts easy to understand for any health professional, from students to seasoned ones, working in pharmaceutical sciences or in clinical practice. Particularly useful are the practical examples, learning outcomes, summaries and questions, which combine and support the above-mentioned features to provide a unique, highly recommended book in human drug metabolism that will remain a reference textbook in the field." ©Doody's Review Service, 2025, Marc Ilies, PhD (Temple University School of Pharmacy)

• 1. Absorption, Distribution, Metabolism and Excretion (ADME)2. The Clinical Relevance of Metabolism3. Oxidative Phase I Metabolic Transformations4. Other Phase I Metabolic Transformations5. Phase II Metabolic Transformations6. Phase III Metabolic Processes