Biomedical Applications of Inorganic Photochemistry

Peter C. Ford is at the Department of Chemistry and Biochemistry, University of California Santa Barbara, CA, USA. Rudi van Eldik was born in Amsterdam (The Netherlands) in 1945 and grew up in Johannesburg (South Africa). He received his chemistry education and DSc degree at the former Potchefstroom University (SA), followed by post-doctoral work at the State University of New York at Buffalo (USA) and the University of Frankfurt (Germany). After completing his Habilitation in Physical Chemistry at the University of Frankfurt in 1982, he was appointed as Professor of Inorganic Chemistry at the Private University of Witten/Herdecke in 1987. In 1994 he became Professor of Inorganic and Analytical Chemistry at the University of Erlangen-Nürnberg, from where he retired in 2010. At present he is Professor of Inorganic Chemistry at the Jagiellonian University in Krakow, Poland, and Visiting Professor of Inorganic Chemistry at the N. Copernicus University in Torun, Poland.His research interests cover the elucidation of inorganic and bioinorganic reaction mechanisms, with special emphasis on the application of high pressure thermodynamic and kinetic techniques. In recent years his research team also focused on the application of low-temperature rapid-scan techniques to identify and study reactive intermediates in catalytic cycles, and on mechanistic studies in ionic liquids. He is Editor of the series Advances in Inorganic Chemistry since 2003. He serves on the Editorial Boards of several chemistry journals. He is the author of over 880 research papers and review articles in international journals and supervised 80 PhD students. He has received honorary doctoral degrees from the former Potchefstroom University, SA (1997), Kragujevac University, Serbia (2006), Jagiellonian University, Krakow, Poland (2010), University of Pretoria, SA (2010), and Ivanovo State University of Chemistry and Technology, Russia (2012). He has developed a promotion activity for chemistry and related experimental sciences in the form of chemistry edutainment presentations during the period 1995-2010. In 2009 he was awarded the Federal Cross of Merit (‘Bundesverdienstkreuz’) by the Federal President of Germany, and the Inorganic Mechanisms Award by the Royal Society of Chemistry (London).His hobbies include music, hiking, jogging, cycling and motor-biking. He is the father of two and grandfather of four children.

• PrefacePeter C. Ford and Rudi van Eldik1. Leveraging the photophysical properties of rhenium(I) tricarbonyl complexes for biomedical applicationsJustin J. Wilson2. Strategic design of photofunctional transition metal complexes for cancer diagnosis and therapyLawrence Cho-Cheung Lee and Kenneth Kam-Wing Lo3. Advances in the design of photoactivated platinum anticancer complexesHuayun Shi and Peter J. Sadler4. Adventures in the photo-uncaging of small molecule bioregulatorsPeter C. Ford5. Inorganic nanoparticles engineered for light-triggered unconventional therapiesAurore Fraix and Salvatore Sortino6. Photoactive manganese carbonyl complexes with fac-{Mn(CO)3} moiety: Design, application, and potential as prodrugs in CO therapyIndranil Chakraborty and Pradip K. Mascharak7. Mechanistic insight into photoactivation of small inorganic molecules from the biomedical applications perspectivesA. Kyzioł, Ł. Orzeł, I. Gurgul, O. Mazuryk, P. Łabuz and G. Stochel8. Ruthenium complexes for photoactivated dual activity: Drug delivery and singlet oxygen generationSean J. Steinke, Jeremy J. Kodanko and Claudia Turro9. Photochemical biosignaling with ruthenium complexesOscar Filevich and Roberto Etchenique10. Ruthenium phthalocyanines in nitric oxide modulation and singlet oxygen release: selectivity and cytotoxic effect on cancer cell linesRenata Galvão de Lima, Rafaella Rebecchi Rios, Antonio Eduardo da Hora Machado and Roberto Santana da Silva11. Photoactive Organometallics as Antimicrobial AgentsAshwene Rajagopal, Jack Biddulph, Leila Tabrizi, Deirdre Fitzgerald-Hughes and Mary T. Pryce12. Mitochondria-Targeting Transition Metal ComplexesRyan J. Morris and Massimiliano Massi