Precision Medicine

David B. Teplow, Ph.D., is a Professor of Neurology, Emeritus, at UCLA and an internationally recognized leader in efforts to understand and treat Alzheimer's disease. Dr. Teplow's group has used a multi-disciplinary approach to determine how neurotoxic peptides, such as the amyloid β-protein (Alzheimer's disease) and α-synuclein (Parkinson’s disease), form neurotoxic structures that kill neurons and to develop the means to block these processes. Dr. Teplow received undergraduate training at UC Berkeley; a Ph.D. from the University of Washington; and was a postdoctoral scholar at Caltech. Before coming to UCLA, Dr. Teplow was a faculty member in the Department of Neurology, Harvard Medical School. Dr. Teplow has published >250 peer-reviewed articles, books and book chapters, and commentaries, in addition to serving on numerous national and international scientific advisory boards. Dr. Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology, He is Editor-in-Chief of the Elsevier serial Progress in Molecular Biology and Translational Science and is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease.

• PrefaceDavid B. Teplow1. Introduction of medical genomics and clinical informatics integration for p-Health careLi Tong, Hang Wu, May D. Wang and Geoffrey Wang2. Precision diagnostics in cancer: Predict, prevent, and personalizeJudy S. Crabtree and Lucio Miele3. Artificial intelligence and machine learning in precision medicine: A paradigm shift in big data analysisMehar Sahu, Rohan Gupta, Rashmi K Ambasta and Pravir Kumar4. Precision medicine with multi-omics strategies, deep phenotyping, and predictive analysisZeeshan Ahmed5. Progress in molecular biology and translational science addressing the needs of nano-rare patientsStanley T. Crooke6. Precision medicine in epilepsyRyan James McGinn, Erica Leah Von Stein, Jacqueline Elizabeth Summers Stromberg and Yi Li7. EGFR, NF-κB and noncoding RNAs in precision medicineYanli Li, Xiaomin Liu and Zhongliang Ma8. Evolution of biomarker research in autoimmunity conditions for health professionals and clinical practiceArthur Silverstein, Anton Dudaev, Maria Studneva, John Aitken, Sofya Blokh, Andrew David Miller, Sofia Tanasova, Noel Rose, John Ryals, Christoph Borchers, Anders Nordstrom, Marina Moiseyakh, Arturo Solís Herrera, Nikita Skomorohov, Trevor Marshall, Alan Wu, R Holland Cheng, Ksenia Syzko, Philip D. Cotter, Marianna Podzyuban, William Thilly, Paul David Smith, Paul Barach, Khaled Bouri, Yehuda Schoenfeld, Eiji Matsuura, Veronika Medvedeva, Ilya Shmulevich, Liang Cheng, Paul Seegers, Yekaterina Khotskaya, Keith Flaherty, Steven Dooley, Eric J. Sorenson, Michael Ross and Sergey Suchkov