Valerie Luyckx is Affiliate Lecturer, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, Institute of Biomedical Ethics and the History of MedicineUniversity of Zurich, Zurich, Switzerland. Glenn M. Chertow is Norman S. Coplon/ Satellite Healthcare, Professor of Medicine, Chief, Division of Nephrology at Stanford University School of Medicine, Stanford, Palo Alto, California, USA Philip A. Marsden is Professor of Medicine, Elisabeth Hofmann Chair in Translational Research, Oreopoulos-Baxter Division Director of Nephrology; Vice Chair Research, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Karl Skorecki is Annie Chutick Professor and Chair in Medicine (Nephrology), Technion-Israel Institute of Technology, Director of Medical and Research Development, Rambam Health Care Campus, Haifa, Israel. Professor of Medicine Maarten W. Taal works in the Division of Medical Sciences and Graduate Entry Medicine at University of Nottingham; Honorary Consultant Nephrologist, Department of Renal Medicine, Royal Derby Hospital, Derby, UK. Alan S. L. Yu is Harry Statland and Solon Summerfield Professor of Medicine, Director, Division of Nephrology and Hypertension and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.

4 Stars! "This physical textbook is an imposing, two-volume set of hardbound books, each over 1,000 pages... [and] extensive additional illustrations and references...in the online edition. The book acts as 'a compendium of Nephrology,' covering essentially all aspects of the relevant medical care and basic science. Its excellent, thorough content accomplishes that goal, and it is still the definitive textbook in the fields of nephrology and renal physiology.... Most usefully, the condensed discussion of treatment for glomerular diseases in prior editions has been expanded from two omnibus chapters into seven different sections covering individual diseases.... Though intimidating in its length, this is an accessible and uniformly well-written, well-designed textbook. The current text appears to be the best in this field in terms of depth and clarity.... It has historically been the key title in the field of nephrology, and that remains the case with the updates in the twelfth edition." Review by Sam Beavin, MD (University of Kentucky College of Medicine), ©Doody's Review Service, 2026. Doody's Score: 94, 4 Stars!

• VOLUME 1SECTION: NORMAL STRUCTURE AND FUNCTION1. Embryology of the Kidney2. Anatomy of the Kidney3. Renal Circulation and Glomerular Filtration4. Glomerular Cell Biology and Podocytopathies5. Kidney Metabolism6. Transport of Sodium, Chloride, and Potassium7. Transport of Calcium, Magnesium, and Phosphate8. Renal Handling of Organic Solutes9. Renal Acidification Mechanisms10. Urine Concentration and Dilution11. Vasoactive Molecules and the Kidney12. Aldosterone and Mineralocorticoid Receptors: Renal and Extrarenal RolesSECTION II DISORDERS OF BODY FLUID VOLUME AND COMPOSITION13. Disorders of Sodium Balance14. Disorders of Water Balance15. Disorders of Acid-Base Balance16. Disorders of Potassium Balance17. Disorders of Calcium, Magnesium, and Phosphate BalanceSECTION III EPIDEMIOLOGY AND RISK FACTORS IN KIDNEY DISEASE18. Epidemiology of Kidney Disease19. Risk Prediction in Chronic Kidney Disease20. Early Life Origins of Hypertension and Chronic Kidney Disease21. The Physiology and Pathophysiology of the Kidneys in Aging22. Sex and Gender in Kidney Health and DiseaseSECTION IV EVALUATION OF THE PATIENT WITH KIDNEY DISEASE23. Laboratory Assessment of Kidney Disease: Glomerular Filtration Rate, Proteinuria, and Urinalysis24. Diagnostic Kidney Imaging25. The Renal Biopsy26. Point-of-Care UltrasoundSECTION V DISORDERS OF KIDNEY STRUCTURE AND FUNCTION27. Pathophysiology of Acute Kidney Injury28. Prevention and Management of Acute Kidney Injury29. Pathophysiology of Proteinuria30. Nephrotic Syndrome: Primary and Secondary31. Lupus Nephritis and Other Kidney Manifestations of Systemic Inflammatory and Autoimmune Diseases32. Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and Antiglomerular Basement Membrane Disease33. IgA Nephropathy and IgA Vasculitis34. Infection-Related Glomerulonephritis35. Kidney Lesions Associated With Dysproteinemias36. Complement-Mediated Kidney Diseases37. Tubulointerstitial Diseases38. Urinary Tract Infection in Adults39. Urinary Tract Obstruction40. Nephrolithiasis41. Diabetic Kidney Disease42. Cardiovascular Disease in Persons With Chronic Kidney Disease43. Kidney CancerVOLUME 2SECTION VI GENETICS OF KIDNEY DISEASE44. Genetics of Kidney Disease45. Cystic Kidney DiseasesSECTION VII HYPERTENSION AND THE KIDNEY46 Primary and Secondary Hypertension47. Renovascular Hypertension and Ischemic Nephropathy48. Antihypertensive Therapy49. DiureticsSECTION VIII CONSEQUENCES OF CHRONIC KIDNEY DISEASE50. Mechanisms of Progression in Chronic Kidney Disease51. The Pathophysiology of Uremia52. Chronic Kidney Disease-Mineral Bone Disorder53. Hematologic Aspects of Kidney DiseaseSECTION IX MANAGEMENT OF CHRONIC KIDNEY DISEASE54. Classification and Management of Chronic Kidney Disease55. Dietary Approaches to Kidney Diseases56. Drug Dosing Considerations in Patients With Acute Kidney Injury and Chronic Kidney Disease57. Onconephrology: Kidney Disease and Cancer58. Pregnancy and Kidney Disease59. Infectious Diseases and the Kidney60. Care of the Older Adult With Chronic Kidney Disease61. Kidney Supportive Care in Advanced Chronic Kidney DiseaseSECTION X DIALYSIS AND EXTRACORPOREAL THERAPIES62. Hemodialysis63. Peritoneal Dialysis64. Critical Care Nephrology65. Therapeutic Plasma Exchange and Other Extracorporeal Treatments in Management of Kidney and Related Diseases66. Enhanced Elimination of Poisons67. Interventional Nephrology: Managing Dialysis Access and Kidney BiopsySECTION XI KIDNEY TRANSPLANTATION68. The Immunobiology of Transplantation69. Clinical Management of the Adult Kidney Transplant Recipient70. Considerations in Living Kidney DonationSECTION XII PEDIATRIC NEPHROLOGY71. Childhood Kidney Disease72. Kidney Replacement Therapy (Dialysis and Transplantation) in ChildrenSECTION XIII GLOBAL CONSIDERATIONS IN KIDNEY DISEASE73. Global Challenges and Progress in Kidney Health74. Global Considerations in Kidney Disease: Latin America75. Global Considerations in Kidney Disease: Africa76. Global Considerations in Kidney Disease: Near and Middle East77. Global Considerations in Kidney Disease: Indian Subcontinent78. Global Considerations in Kidney Disease: The Far East79. Global Considerations in Kidney Disease: The Pacific Islands and Islands of the CaribbeanSECTION XIV CHALLENGES IN NEPHROLOGY80. Ethical Dilemmas Facing Nephrology81. Health Disparities in Nephrology82. Disaster Nephrology83. Chronic Kidney Disease of Uncertain Etiology84. Stem Cells, Kidney Regeneration, and Gene and Cell Therapy in Nephrology

Valerie Luyckx is Affiliate Lecturer, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, Institute of Biomedical Ethics and the History of MedicineUniversity of Zurich, Zurich, Switzerland. Glenn M. Chertow is Norman S. Coplon/ Satellite Healthcare, Professor of Medicine, Chief, Division of Nephrology at Stanford University School of Medicine, Stanford, Palo Alto, California, USA Philip A. Marsden is Professor of Medicine, Elisabeth Hofmann Chair in Translational Research, Oreopoulos-Baxter Division Director of Nephrology; Vice Chair Research, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Karl Skorecki is Annie Chutick Professor and Chair in Medicine (Nephrology), Technion-Israel Institute of Technology, Director of Medical and Research Development, Rambam Health Care Campus, Haifa, Israel. Professor of Medicine Maarten W. Taal works in the Division of Medical Sciences and Graduate Entry Medicine at University of Nottingham; Honorary Consultant Nephrologist, Department of Renal Medicine, Royal Derby Hospital, Derby, UK. Alan S. L. Yu is Harry Statland and Solon Summerfield Professor of Medicine, Director, Division of Nephrology and Hypertension and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.

4 Stars! "This physical textbook is an imposing, two-volume set of hardbound books, each over 1,000 pages... [and] extensive additional illustrations and references...in the online edition. The book acts as 'a compendium of Nephrology,' covering essentially all aspects of the relevant medical care and basic science. Its excellent, thorough content accomplishes that goal, and it is still the definitive textbook in the fields of nephrology and renal physiology.... Most usefully, the condensed discussion of treatment for glomerular diseases in prior editions has been expanded from two omnibus chapters into seven different sections covering individual diseases.... Though intimidating in its length, this is an accessible and uniformly well-written, well-designed textbook. The current text appears to be the best in this field in terms of depth and clarity.... It has historically been the key title in the field of nephrology, and that remains the case with the updates in the twelfth edition." Review by Sam Beavin, MD (University of Kentucky College of Medicine), ©Doody's Review Service, 2026. Doody's Score: 94, 4 Stars!

• VOLUME 1SECTION: NORMAL STRUCTURE AND FUNCTION1. Embryology of the Kidney2. Anatomy of the Kidney3. Renal Circulation and Glomerular Filtration4. Glomerular Cell Biology and Podocytopathies5. Kidney Metabolism6. Transport of Sodium, Chloride, and Potassium7. Transport of Calcium, Magnesium, and Phosphate8. Renal Handling of Organic Solutes9. Renal Acidification Mechanisms10. Urine Concentration and Dilution11. Vasoactive Molecules and the Kidney12. Aldosterone and Mineralocorticoid Receptors: Renal and Extrarenal RolesSECTION II DISORDERS OF BODY FLUID VOLUME AND COMPOSITION13. Disorders of Sodium Balance14. Disorders of Water Balance15. Disorders of Acid-Base Balance16. Disorders of Potassium Balance17. Disorders of Calcium, Magnesium, and Phosphate BalanceSECTION III EPIDEMIOLOGY AND RISK FACTORS IN KIDNEY DISEASE18. Epidemiology of Kidney Disease19. Risk Prediction in Chronic Kidney Disease20. Early Life Origins of Hypertension and Chronic Kidney Disease21. The Physiology and Pathophysiology of the Kidneys in Aging22. Sex and Gender in Kidney Health and DiseaseSECTION IV EVALUATION OF THE PATIENT WITH KIDNEY DISEASE23. Laboratory Assessment of Kidney Disease: Glomerular Filtration Rate, Proteinuria, and Urinalysis24. Diagnostic Kidney Imaging25. The Renal Biopsy26. Point-of-Care UltrasoundSECTION V DISORDERS OF KIDNEY STRUCTURE AND FUNCTION27. Pathophysiology of Acute Kidney Injury28. Prevention and Management of Acute Kidney Injury29. Pathophysiology of Proteinuria30. Nephrotic Syndrome: Primary and Secondary31. Lupus Nephritis and Other Kidney Manifestations of Systemic Inflammatory and Autoimmune Diseases32. Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and Antiglomerular Basement Membrane Disease33. IgA Nephropathy and IgA Vasculitis34. Infection-Related Glomerulonephritis35. Kidney Lesions Associated With Dysproteinemias36. Complement-Mediated Kidney Diseases37. Tubulointerstitial Diseases38. Urinary Tract Infection in Adults39. Urinary Tract Obstruction40. Nephrolithiasis41. Diabetic Kidney Disease42. Cardiovascular Disease in Persons With Chronic Kidney Disease43. Kidney CancerVOLUME 2SECTION VI GENETICS OF KIDNEY DISEASE44. Genetics of Kidney Disease45. Cystic Kidney DiseasesSECTION VII HYPERTENSION AND THE KIDNEY46 Primary and Secondary Hypertension47. Renovascular Hypertension and Ischemic Nephropathy48. Antihypertensive Therapy49. DiureticsSECTION VIII CONSEQUENCES OF CHRONIC KIDNEY DISEASE50. Mechanisms of Progression in Chronic Kidney Disease51. The Pathophysiology of Uremia52. Chronic Kidney Disease-Mineral Bone Disorder53. Hematologic Aspects of Kidney DiseaseSECTION IX MANAGEMENT OF CHRONIC KIDNEY DISEASE54. Classification and Management of Chronic Kidney Disease55. Dietary Approaches to Kidney Diseases56. Drug Dosing Considerations in Patients With Acute Kidney Injury and Chronic Kidney Disease57. Onconephrology: Kidney Disease and Cancer58. Pregnancy and Kidney Disease59. Infectious Diseases and the Kidney60. Care of the Older Adult With Chronic Kidney Disease61. Kidney Supportive Care in Advanced Chronic Kidney DiseaseSECTION X DIALYSIS AND EXTRACORPOREAL THERAPIES62. Hemodialysis63. Peritoneal Dialysis64. Critical Care Nephrology65. Therapeutic Plasma Exchange and Other Extracorporeal Treatments in Management of Kidney and Related Diseases66. Enhanced Elimination of Poisons67. Interventional Nephrology: Managing Dialysis Access and Kidney BiopsySECTION XI KIDNEY TRANSPLANTATION68. The Immunobiology of Transplantation69. Clinical Management of the Adult Kidney Transplant Recipient70. Considerations in Living Kidney DonationSECTION XII PEDIATRIC NEPHROLOGY71. Childhood Kidney Disease72. Kidney Replacement Therapy (Dialysis and Transplantation) in ChildrenSECTION XIII GLOBAL CONSIDERATIONS IN KIDNEY DISEASE73. Global Challenges and Progress in Kidney Health74. Global Considerations in Kidney Disease: Latin America75. Global Considerations in Kidney Disease: Africa76. Global Considerations in Kidney Disease: Near and Middle East77. Global Considerations in Kidney Disease: Indian Subcontinent78. Global Considerations in Kidney Disease: The Far East79. Global Considerations in Kidney Disease: The Pacific Islands and Islands of the CaribbeanSECTION XIV CHALLENGES IN NEPHROLOGY80. Ethical Dilemmas Facing Nephrology81. Health Disparities in Nephrology82. Disaster Nephrology83. Chronic Kidney Disease of Uncertain Etiology84. Stem Cells, Kidney Regeneration, and Gene and Cell Therapy in Nephrology

Valerie Luyckx is Affiliate Lecturer, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, Institute of Biomedical Ethics and the History of MedicineUniversity of Zurich, Zurich, Switzerland. Glenn M. Chertow is Norman S. Coplon/ Satellite Healthcare, Professor of Medicine, Chief, Division of Nephrology at Stanford University School of Medicine, Stanford, Palo Alto, California, USA Philip A. Marsden is Professor of Medicine, Elisabeth Hofmann Chair in Translational Research, Oreopoulos-Baxter Division Director of Nephrology; Vice Chair Research, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Karl Skorecki is Annie Chutick Professor and Chair in Medicine (Nephrology), Technion-Israel Institute of Technology, Director of Medical and Research Development, Rambam Health Care Campus, Haifa, Israel. Professor of Medicine Maarten W. Taal works in the Division of Medical Sciences and Graduate Entry Medicine at University of Nottingham; Honorary Consultant Nephrologist, Department of Renal Medicine, Royal Derby Hospital, Derby, UK. Alan S. L. Yu is Harry Statland and Solon Summerfield Professor of Medicine, Director, Division of Nephrology and Hypertension and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.

4 Stars! "This physical textbook is an imposing, two-volume set of hardbound books, each over 1,000 pages... [and] extensive additional illustrations and references...in the online edition. The book acts as 'a compendium of Nephrology,' covering essentially all aspects of the relevant medical care and basic science. Its excellent, thorough content accomplishes that goal, and it is still the definitive textbook in the fields of nephrology and renal physiology.... Most usefully, the condensed discussion of treatment for glomerular diseases in prior editions has been expanded from two omnibus chapters into seven different sections covering individual diseases.... Though intimidating in its length, this is an accessible and uniformly well-written, well-designed textbook. The current text appears to be the best in this field in terms of depth and clarity.... It has historically been the key title in the field of nephrology, and that remains the case with the updates in the twelfth edition." Review by Sam Beavin, MD (University of Kentucky College of Medicine), ©Doody's Review Service, 2026. Doody's Score: 94, 4 Stars!

• VOLUME 1SECTION: NORMAL STRUCTURE AND FUNCTION1. Embryology of the Kidney2. Anatomy of the Kidney3. Renal Circulation and Glomerular Filtration4. Glomerular Cell Biology and Podocytopathies5. Kidney Metabolism6. Transport of Sodium, Chloride, and Potassium7. Transport of Calcium, Magnesium, and Phosphate8. Renal Handling of Organic Solutes9. Renal Acidification Mechanisms10. Urine Concentration and Dilution11. Vasoactive Molecules and the Kidney12. Aldosterone and Mineralocorticoid Receptors: Renal and Extrarenal RolesSECTION II DISORDERS OF BODY FLUID VOLUME AND COMPOSITION13. Disorders of Sodium Balance14. Disorders of Water Balance15. Disorders of Acid-Base Balance16. Disorders of Potassium Balance17. Disorders of Calcium, Magnesium, and Phosphate BalanceSECTION III EPIDEMIOLOGY AND RISK FACTORS IN KIDNEY DISEASE18. Epidemiology of Kidney Disease19. Risk Prediction in Chronic Kidney Disease20. Early Life Origins of Hypertension and Chronic Kidney Disease21. The Physiology and Pathophysiology of the Kidneys in Aging22. Sex and Gender in Kidney Health and DiseaseSECTION IV EVALUATION OF THE PATIENT WITH KIDNEY DISEASE23. Laboratory Assessment of Kidney Disease: Glomerular Filtration Rate, Proteinuria, and Urinalysis24. Diagnostic Kidney Imaging25. The Renal Biopsy26. Point-of-Care UltrasoundSECTION V DISORDERS OF KIDNEY STRUCTURE AND FUNCTION27. Pathophysiology of Acute Kidney Injury28. Prevention and Management of Acute Kidney Injury29. Pathophysiology of Proteinuria30. Nephrotic Syndrome: Primary and Secondary31. Lupus Nephritis and Other Kidney Manifestations of Systemic Inflammatory and Autoimmune Diseases32. Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and Antiglomerular Basement Membrane Disease33. IgA Nephropathy and IgA Vasculitis34. Infection-Related Glomerulonephritis35. Kidney Lesions Associated With Dysproteinemias36. Complement-Mediated Kidney Diseases37. Tubulointerstitial Diseases38. Urinary Tract Infection in Adults39. Urinary Tract Obstruction40. Nephrolithiasis41. Diabetic Kidney Disease42. Cardiovascular Disease in Persons With Chronic Kidney Disease43. Kidney CancerVOLUME 2SECTION VI GENETICS OF KIDNEY DISEASE44. Genetics of Kidney Disease45. Cystic Kidney DiseasesSECTION VII HYPERTENSION AND THE KIDNEY46 Primary and Secondary Hypertension47. Renovascular Hypertension and Ischemic Nephropathy48. Antihypertensive Therapy49. DiureticsSECTION VIII CONSEQUENCES OF CHRONIC KIDNEY DISEASE50. Mechanisms of Progression in Chronic Kidney Disease51. The Pathophysiology of Uremia52. Chronic Kidney Disease-Mineral Bone Disorder53. Hematologic Aspects of Kidney DiseaseSECTION IX MANAGEMENT OF CHRONIC KIDNEY DISEASE54. Classification and Management of Chronic Kidney Disease55. Dietary Approaches to Kidney Diseases56. Drug Dosing Considerations in Patients With Acute Kidney Injury and Chronic Kidney Disease57. Onconephrology: Kidney Disease and Cancer58. Pregnancy and Kidney Disease59. Infectious Diseases and the Kidney60. Care of the Older Adult With Chronic Kidney Disease61. Kidney Supportive Care in Advanced Chronic Kidney DiseaseSECTION X DIALYSIS AND EXTRACORPOREAL THERAPIES62. Hemodialysis63. Peritoneal Dialysis64. Critical Care Nephrology65. Therapeutic Plasma Exchange and Other Extracorporeal Treatments in Management of Kidney and Related Diseases66. Enhanced Elimination of Poisons67. Interventional Nephrology: Managing Dialysis Access and Kidney BiopsySECTION XI KIDNEY TRANSPLANTATION68. The Immunobiology of Transplantation69. Clinical Management of the Adult Kidney Transplant Recipient70. Considerations in Living Kidney DonationSECTION XII PEDIATRIC NEPHROLOGY71. Childhood Kidney Disease72. Kidney Replacement Therapy (Dialysis and Transplantation) in ChildrenSECTION XIII GLOBAL CONSIDERATIONS IN KIDNEY DISEASE73. Global Challenges and Progress in Kidney Health74. Global Considerations in Kidney Disease: Latin America75. Global Considerations in Kidney Disease: Africa76. Global Considerations in Kidney Disease: Near and Middle East77. Global Considerations in Kidney Disease: Indian Subcontinent78. Global Considerations in Kidney Disease: The Far East79. Global Considerations in Kidney Disease: The Pacific Islands and Islands of the CaribbeanSECTION XIV CHALLENGES IN NEPHROLOGY80. Ethical Dilemmas Facing Nephrology81. Health Disparities in Nephrology82. Disaster Nephrology83. Chronic Kidney Disease of Uncertain Etiology84. Stem Cells, Kidney Regeneration, and Gene and Cell Therapy in Nephrology