Robert Wyllie is Chief of Medical Operations, Associate Chief of Staff at Cleveland Clinic, Professor of Pediatrics, Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio. Jeffrey S. Hyams is Head, Division of Digestive Diseases, Hepatology, and Nutrition at Connecticut Children's Medical Center, Hartford, Connecticut; Professor of Pediatrics at University of Connecticut School of Medicine, Farmington, Connecticut. Marsha Kay is Chair in the Department of Pediatric Gastroenterology and Nutrition, Director, Pediatric Endoscopy at Cleveland Clinic Children's Hospital, Cleveland, Ohio.

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• SECTION 1 Biologic Aspects of Gastrointestinal Function1. Development of the Gastrointestinal Tract2. Basic Aspects of Digestion and Absorption3. Bile Acid Physiology and Alterations in the Enterohepatic Circulation4. The Gut Microbiome in PediatricsSECTION 2 Clinical Problems5. Gastrointestinal Mucosal Immunology and Mechanisms of Inflammation6. Chronic Abdominal Pain of Childhood and Adolescence7. Approach to the Child With a Disorder of Gut-Brain Interaction8. Vomiting and Nausea9. Diarrhea10. Colic and Gastrointestinal Gas11. Functional Constipation and Fecal Incontinence12. Growth Faltering (Failure to Thrive)13. Gastrointestinal Hemorrhage14. Obesity15. Eating Disorders in Children and Adolescents16. Jaundice: Unconjugated Hyperbilirubinemia17. Ascites18. Caustic Ingestion and Foreign BodiesSECTION 3 The Esophagus19. Developmental Anatomy and Physiology of the Esophagus20. Congenital Malformations of the Esophagus21. Gastroesophageal Reflux22. Achalasia and Other Motor Disorders23. Other Diseases of the EsophagusSECTION 4 The Stomach24. Developmental Anatomy and Physiology of the Stomach25. Congenital Anomalies and Surgical Disorders of the Stomach26. Gastritis, Gastropathy, and Ulcer Disease27. Helicobacter pylori in Childhood28. Gastric Motility Disorders29. BezoarsSECTION 5 The Small and Large Intestine30. Anatomy and Physiology of the Small and Large Intestines31. Maldigestion and Malabsorption32. Protracted Diarrhea33. Protein-Losing Enteropathy34. Celiac Disease35. Short Bowel Syndrome36. Surgical Management of Pediatric Gut Failure: Decades of Innovation and Integration With Rewarding Long-Term Outcomes37. Allergic and Eosinophilic Gastrointestinal Disease38. Infectious Diarrhea39. Enteric Parasites40. Gastrointestinal Manifestations of Immunodeficiency41. Pediatric Polyposis Syndromes42. Crohn’s Disease43. Ulcerative Colitis in Children and Adolescents44. Chronic Intestinal Pseudo-Obstruction45. Neonatal Necrotizing Enterocolitis46. Disorders of the Anorectum Fissures, Fistulas, Prolapse, Hemorrhoids, Tags47. Neoplasms of the Gastrointestinal Tract48. Neoplasms of the Liver49. Other Diseases of the Small Intestine and Colon50. AppendicitisSECTION 6 Pediatric Surgical Disorders51. Intussusception in Infants and Children52. Inguinal Hernias and Hydroceles53. Meckel Diverticula and Omphalomesenteric Duct Remnants54. Hirschsprung Disease55. Imperforate Anus56. Abnormal Rotation and Fixation of the Intestine57. Small and Large Bowel Stenosis and Atresias58. Newborn Abdominal Wall Defects59. Gastrostomy, Jejunostomy, and Stomas of the Small and Large IntestineSECTION 7 Gastrointestinal Procedures60. Esophagogastroduodenoscopy and Related Techniques61. Colonoscopy, Polypectomy, and Related Techniques62. Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound63. Capsule Endoscopy and Small Bowel Enteroscopy64. Gastrointestinal Motility Procedures65. Gastrointestinal Pathology66. Liver Pathology67. Anesthesia and Sedation for Pediatric Gastroenterology Procedures and PatientsSECTION 8 The Liver and Bile Ducts68. Structural and Functional Development of the Hepatobiliary System69. Neonatal Hepatitis70. Biliary Atresia and Neonatal Disorders of the Bile Ducts71. Pediatric Cholestatic Liver Disease72. Mitochondrial Hepatopathies: Disorders of Fatty Acid Oxidation and the Respiratory Chain73. Abnormalities of Hepatic Protein Metabolism74. Abnormalities of Carbohydrate Metabolism and the Liver75. Nonalcoholic Fatty Liver Disease76. Acute and Chronic Hepatitis77. Portal Hypertension78. Liver Failure79. Liver Transplantation in Children80. Diseases of the GallbladderSECTION 9 The Pancreas81. Pancreatic Development82. Cystic Fibrosis and Congenital Anomalies of the Exocrine Pancreas83. Pancreatitis84. Total Pancreatectomy With Islet Autotransplantation85. Pancreatic Neuroendocrine TumorsSECTION 10 Nutrition86. Infant and Toddler Nutrition87. Nutritional Assessment88. Tubes for Enteric Access89. Parenteral Nutrition90. Enteral Nutrition91. Management of Diarrhea92. Effects of Digestive Diseases on Bone Metabolism93. Nutrition and Feeding for Children With Developmental Disabilities94. Fecal Transplant

Robert Wyllie is Chief of Medical Operations, Associate Chief of Staff at Cleveland Clinic, Professor of Pediatrics, Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio. Jeffrey S. Hyams is Head, Division of Digestive Diseases, Hepatology, and Nutrition at Connecticut Children's Medical Center, Hartford, Connecticut; Professor of Pediatrics at University of Connecticut School of Medicine, Farmington, Connecticut. Marsha Kay is Chair in the Department of Pediatric Gastroenterology and Nutrition, Director, Pediatric Endoscopy at Cleveland Clinic Children's Hospital, Cleveland, Ohio.

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• SECTION 1 Biologic Aspects of Gastrointestinal Function1. Development of the Gastrointestinal Tract2. Basic Aspects of Digestion and Absorption3. Bile Acid Physiology and Alterations in the Enterohepatic Circulation4. The Gut Microbiome in PediatricsSECTION 2 Clinical Problems5. Gastrointestinal Mucosal Immunology and Mechanisms of Inflammation6. Chronic Abdominal Pain of Childhood and Adolescence7. Approach to the Child With a Disorder of Gut-Brain Interaction8. Vomiting and Nausea9. Diarrhea10. Colic and Gastrointestinal Gas11. Functional Constipation and Fecal Incontinence12. Growth Faltering (Failure to Thrive)13. Gastrointestinal Hemorrhage14. Obesity15. Eating Disorders in Children and Adolescents16. Jaundice: Unconjugated Hyperbilirubinemia17. Ascites18. Caustic Ingestion and Foreign BodiesSECTION 3 The Esophagus19. Developmental Anatomy and Physiology of the Esophagus20. Congenital Malformations of the Esophagus21. Gastroesophageal Reflux22. Achalasia and Other Motor Disorders23. Other Diseases of the EsophagusSECTION 4 The Stomach24. Developmental Anatomy and Physiology of the Stomach25. Congenital Anomalies and Surgical Disorders of the Stomach26. Gastritis, Gastropathy, and Ulcer Disease27. Helicobacter pylori in Childhood28. Gastric Motility Disorders29. BezoarsSECTION 5 The Small and Large Intestine30. Anatomy and Physiology of the Small and Large Intestines31. Maldigestion and Malabsorption32. Protracted Diarrhea33. Protein-Losing Enteropathy34. Celiac Disease35. Short Bowel Syndrome36. Surgical Management of Pediatric Gut Failure: Decades of Innovation and Integration With Rewarding Long-Term Outcomes37. Allergic and Eosinophilic Gastrointestinal Disease38. Infectious Diarrhea39. Enteric Parasites40. Gastrointestinal Manifestations of Immunodeficiency41. Pediatric Polyposis Syndromes42. Crohn’s Disease43. Ulcerative Colitis in Children and Adolescents44. Chronic Intestinal Pseudo-Obstruction45. Neonatal Necrotizing Enterocolitis46. Disorders of the Anorectum Fissures, Fistulas, Prolapse, Hemorrhoids, Tags47. Neoplasms of the Gastrointestinal Tract48. Neoplasms of the Liver49. Other Diseases of the Small Intestine and Colon50. AppendicitisSECTION 6 Pediatric Surgical Disorders51. Intussusception in Infants and Children52. Inguinal Hernias and Hydroceles53. Meckel Diverticula and Omphalomesenteric Duct Remnants54. Hirschsprung Disease55. Imperforate Anus56. Abnormal Rotation and Fixation of the Intestine57. Small and Large Bowel Stenosis and Atresias58. Newborn Abdominal Wall Defects59. Gastrostomy, Jejunostomy, and Stomas of the Small and Large IntestineSECTION 7 Gastrointestinal Procedures60. Esophagogastroduodenoscopy and Related Techniques61. Colonoscopy, Polypectomy, and Related Techniques62. Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound63. Capsule Endoscopy and Small Bowel Enteroscopy64. Gastrointestinal Motility Procedures65. Gastrointestinal Pathology66. Liver Pathology67. Anesthesia and Sedation for Pediatric Gastroenterology Procedures and PatientsSECTION 8 The Liver and Bile Ducts68. Structural and Functional Development of the Hepatobiliary System69. Neonatal Hepatitis70. Biliary Atresia and Neonatal Disorders of the Bile Ducts71. Pediatric Cholestatic Liver Disease72. Mitochondrial Hepatopathies: Disorders of Fatty Acid Oxidation and the Respiratory Chain73. Abnormalities of Hepatic Protein Metabolism74. Abnormalities of Carbohydrate Metabolism and the Liver75. Nonalcoholic Fatty Liver Disease76. Acute and Chronic Hepatitis77. Portal Hypertension78. Liver Failure79. Liver Transplantation in Children80. Diseases of the GallbladderSECTION 9 The Pancreas81. Pancreatic Development82. Cystic Fibrosis and Congenital Anomalies of the Exocrine Pancreas83. Pancreatitis84. Total Pancreatectomy With Islet Autotransplantation85. Pancreatic Neuroendocrine TumorsSECTION 10 Nutrition86. Infant and Toddler Nutrition87. Nutritional Assessment88. Tubes for Enteric Access89. Parenteral Nutrition90. Enteral Nutrition91. Management of Diarrhea92. Effects of Digestive Diseases on Bone Metabolism93. Nutrition and Feeding for Children With Developmental Disabilities94. Fecal Transplant