Essentials of Pharmatoxicology in Drug Research, Volume 1

Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.

• 1. Understanding Pharmacotoxicology2. Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development3. Omics in Mechanistic and Predictive Toxicology4. Role of Micro RNAs in Toxicology5. Exosomes as Mediators of Chemical-Induced Toxicity6. Types of Cellular Responses to Chemical Toxicants7. Tissue Repair as A Key Determinant in Toxicant-Induced Injury8. Role Of “Toxicant-Induced Loss of Tolerance” in the Emergence of Disease9. Computer-Aided Technologies in Drug Discovery and Toxicity Prediction10. Adverse Outcome Pathway for Chemical Toxicity11. Toxicokinetics and Organ-Specific Toxicity12. Dose Selection for Toxicity Studies13. Tissue-Based Models as A Replacement for Animal Models in Toxicity Testing14. Medication Error and its Toxicity Connection15. Idiosyncratic Toxicity16. Toxicological Risk Assessment17. Clinical Detoxification of the Body18. Principles of Management of Acute Poisoning19. Predicting Toxicity and Modes of Toxic Action from Chemical Structure20. Toxicity Labels21. Toxic Potential Indicator22. Aquatic Toxicology23. Concept of Pharmacotherapy and Managed Care in Clinical Interventions24. Psychopharmacology in Late Life: Key Challenges and Opportunities25. Regulatory Agencies for Toxicity Studies26. Key Challenges for Toxicologists in the 21st Century