Nima Rezaei, MD, PhD, is Professor of Clinical Immunology and Allergy at Tehran University of Medical Sciences, where he also serves as Associate Dean of International Affairs for the School of Medicine and Director of the Global Academic Program. He is Deputy President of the Research Center for Immunodeficiencies and holds an affiliated research appointment in the Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet, Sweden. He earned his MD from Tehran University of Medical Sciences and his PhD in Clinical Immunology and Human Genetics from the University of Sheffield, United Kingdom. His research addresses primary immunodeficiencies and translational immunology, with recent work extending into computational and AI-based approaches to immune profiling. He is the founder and President of the Universal Scientific Education and Research Network (USERN) and serves as co-editor of the Springer Nature series Advances in Experimental Medicine and Biology.

• 1. Introduction on the Neuroimmunology of Multiple Sclerosis2. Immunopathology of multiple sclerosis3. Biomarkers of multiple sclerosis4. Translational research into the pathogenesis of secondary progressive multiple sclerosis5. Neuroimmunology of fatigue in multiple sclerosis6. Microbiome and multiple sclerosis7. Interaction with parasites and herpesviruses in people with multiple sclerosis - potential applications for prevention and treatment8. Cytotoxic cells in multiple sclerosis: new targets for treatment9. Targeting leukocytes in multiple sclerosis: therapeutic perspectives10. Antibodies and antibody fragments developed for treatment of multiple sclerosis11. Sphingosine-1-Phosphate, its Receptors, and their Role in Multiple Sclerosis, an Inflammatory and Autoimmune Disease of the Central Nervous Systems12. Innate and adaptive immunomodulation by burton tyrosine kinase (BTK) inhibitors: review of emerging multiple sclerosis treatment