Endothelium and Cardiovascular Diseases

Professor Protásio L. da Luz, MD, FACC received his medical degree and completed a Residency and Specialization in Cardiology at Universidade de São Paulo Brazil (USP), and completed a postgraduate Fellowship in Critical Care Medicine at the University of Southern California. He has been a Research Scientist at Cedars-Sinai Medical Center, Full Professor of Cardiology at the Heart Institute (InCor) School of Medicine, USP, and Director of the InCor’s Cardiology Division and Atherosclerosis Unit. He is a Full Member of the Brazilian Academy of Sciences, Academy of Sciences of the State of São Paulo, and has authored or co-authored over 490 scientific publications and book chapters (258 of them peer-reviewed). Primary research interests include endothelium, atherosclerosis, coronary artery disease and prevention, and translational medicine. He received the Brazilian National Award for Scientific Merit, the Order of Medical Merit from the Brazilian government, and the Fundação Conrado Wessel Award in Medicine. Dr. Peter Libby is a cardiovascular medicine specialist at Brigham and Women’s Hospital and Mallinckrodt Professor of Medicine at Harvard Medical School (HMS). Receiving his medical degree from the University of California, San Diego School of Medicine, he undertook a cellular physiology research fellowship at HMS. After a residency in internal medicine and a fellowship in cardiovascular disease, he became board certified in both. He is an editor of the leading cardiovascular medicine textbook, and the author of over 500 peer-reviewed publications, 575 reviews, chapters, etc. He has received funding from the American Heart Association (AHA) and National Institutes of Health, plus recognitions on four continents, including the AHA and American College of Cardiology’s highest research awards, the Gold Medal of the European Society of Cardiology, the Anitschkow award from the European Atherosclerosis Society, the Ernst Jung Gold Medal for Medicine, and the Earl Benditt award for vascular biology. Antonio Carlos Palandri Chagas MD, PhD, is Professor of Medicine and Chief of Cardiology at the Medical School of ABC, São Paulo Brazil, where he earned his medical degree. His Residency in Internal Medicine and postgraduate work in cardiology were at the University of São Paulo; his PhD thesis covered myocardial ischemia. His postdoctoral fellowship was at the University of California San Francisco’s Cardiovascular Research Institute. A Fellow of the American College of Cardiology (ACC) who serves on the board of the JACC, he was the Brazilian Chapter’s first governor. He belongs to the European Society of Cardiology. He was president of the São Paulo State Society of Cardiology, and the Brazilian Society of Cardiology. He attained ACC’s International Service Award; Chief of the Department of Internal Medicine at the Medical School of ABC; and Chair of ACC’s International Assembly of Governors. He has authored over 145 peer-reviewed journal publications. Professor Francisco Rafael Martins Laurindo, MD received his medical degree and completed his Internal Medicine and Cardiology residency at the Heart Institute at the University of São Paulo School of Medicine in Brazil (FMUSP), where he earned his PhD on signaling processes in the vascular system. He trained in Physiology and Pharmacology at the University of Health Sciences, Bethesda, Maryland. He founded and has directed the Vascular Biology Laboratory at the Heart Institute (InCor), FMUSP since 2008. He is author or co-author of over 145 publications in peer-reviewed journals. He is a member of the Board of Directors of the Brazilian Academy of Sciences and a past Council Member of the Society for Free Radical Biology. He belongs to the Editorial Boards of Free Radical Biology and Medicine and Clinical Science, and served as Chair and Vice-Chair of the Gordon Research Conference on Nox Family NADPH Oxidases.

• 1. Signal Transduction Pathways in Endothelial Cells: Implications for Angiogenesis2. Endothelial Barrier: Factors That Regulate Its Permeability3. Hemodynamic Forces in the Endothelium: From Mechanotransduction to Implications on Development of Atherosclerosis4. Endothelium-Dependent Vasodilation: Nitric Oxide and Other Mediators5. Vasoconstrictor Substances Produced by the Endothelium6. Redox Cellular Signaling Pathways in Endothelial Dysfunction and Vascular Disease7. Endothelium and Immune System8. Progenitor Cells - Origins and Endothelium Regeneration9. Blood Coagulation and Endothelium10. Platelets and Endothelium11. Endothelium and Genetics12. Regulation of Endothelial Function: With Focus RNAs, MicroRNAs, and LncRNAs13. Endothelium and Renin-Angiotensin System14. Methods to Investigate Endothelial Function in Humans15. Endothelium to Mesenchymal Transition - Contributions to Vascular Diseases16. Endothelial Products as Plasmatic Biomarker of Vascular Dysfunction17. Endothelial Alterations in Aging18. Vascular Function and Cognitive Decline19. Emotional Stress and Influences on Endothelium20. Cardiac Arrhythmias and Endothelium21. Lipids and Lipoprotein Mediators of Endothelial Function and Dysfunction22. Non-HDL Particles, Triglycerides and Endothelium - NEW CHAPTER23. Risk Factors for Endothelial Dysfunction and Early Onset of Cardiovascular Diseases in the Young24. Endothelial Dysfunction and Myocardial Injury in COVID-1925. Colchicine for the Prevention of Cardiovascular Disease26. Venous Thromboembolism and Endothelium27. Artificial Lipoproteins in Endothelial Dysfunction and Atherosclerosis28. Influences of Diet on Endothelial Dysfunction29. Endothelium and Microbiota as Regulators of Metabolic Process30. Effects of Red Wine and Polyphenols on Endothelial Function and Clinical Events31. Kidney and the Endothelium32. Endothelial Alterations in Pulmonary Hypertension33. Endothelial Alterations in Chronic Coronary Disease34. Molecular Mechanisms of the Arterial Wall in Acute Coronary Syndromes35. Integrating Multiomic Approaches to Uncover Candidate Gene Networks for Endothelial Dysfunction in Response do CVD Risk Factors36. Endothelium - Coordinator of Acute and Chronic Inflammation37. Endothelium in Atherosclerosis: Plaque Formation and Its Complications38. Endothelial Function and Cardiovascular Risk Factors Interactions39. Sleep Disorders and Endothelial Dysfunction40. Smoking and the Endothelium41. Effects of radiation upon Vascular Endothelium42. Endothelial Dysfunction and Coronary Microvascular Dysfunction in Women with Angina and Non-obstructive Coronaries43. Endothelial Alterations in Heart Failure—Mechanisms and Molecular Basis44. Endothelium Function in HF with Preserved EF45. Endothelium in Cardiomyopathies46. Post percutaneous Interventions: Endothelial Repair47. Stents and the Endothelium48. Vascular Disease of the Transplanted Heart: Physiopathology and Therapeutic Options49. Erectile Dysfunction and the Endothelium50. Cardiovascular Actions and Therapeutic Implications of Endothelium-Derived Catecholamines51. Obesity, Endothelium and Metabolic Syndrome52. Endothelium in Diabetes53. Endothelial Mechanisms in Preeclampsia54. Angiogenesis and Tumor Vasculature Function55. Corneal Endothelium Cell Dysfunction56. Connective Tissue and Endothelium57. Physical Exercise and the Endothelium58. The Translational Concept in Endothelium - From Research to Clinical Practice59. Advancements in Understanding the Interplay between Endothelial Dysfunction and Arterial Hypertension