R. Stokes Peebles is Professor of Medicine in the Division of Allergy, Pulmonary and Critical Care Medicine at Vanderbilt University Medical Center, Nashville, Tennessee.

Review of the previous edition: "Since its inception, this two-volume book has served as a comprehensive resource for allergists, specifically fellows-in-training.The present edition continues the reputation of the original, enjoying contributions from over 200 experts in the field." --Massoud Mahmoudi, DO, PhD (University of California San Francisco) Doodys Review Service

• SELF-ASSESSMENT QUESTIONSSelf-assessment questions are included with each chapter and are available in the eBook. See inside the front cover for access details.VOLUME 1SECTION A Basic Sciences Underlying Allergy and Immunology1. Innate Immunity2. Adaptive Immunity3. Immunoglobulin Structure and Function4. Immune Tolerance5. Cytokines in Allergic Inflammation6. Cellular Adhesion in Inflammation7. Chemokines8. The Complement System9. Lipid Mediators of Hypersensitivity and Inflammation10. Molecular Biology and Genetic Engineering11. Biology of Lymphocytes12. Innate Lymphoid Cells13. Antigen Presenting Dendritic Cells14. Biology of Mast Cells and Their Mediators15. Biology of Basophils16. Biology of Eosinophils17. Biology of Neutrophils18. Biology of Monocytes and Macrophages19. Airway Epithelial Cells20. Airway Smooth Muscle in Asthma21. Pathophysiology of Allergic Inflammation22. Genetics and Epigenetics in Allergic Diseases23. Omic and Systems Biology Approaches to Allergic Disease24. Immunobiology of IgE and IgE Receptors25. Neuronal Control of Airway Function in AllergySECTION B Aerobiology and Allergens26 The Structure and Function of Allergens27 Aerobiology of Outdoor Allergens28 Indoor Allergens29 Preparation and Standardization of Allergens and Allergen Extracts30 Air Pollution: Indoor and OutdoorSECTION C The Skin31. Structure of the Skin and Cutaneous Immunology32. Atopic Dermatitis33. Contact Dermatitis34. Urticaria and Angioedema35. Hereditary Angioedema and Bradykinin-Mediated Angioedema36. Immune Complexes in DiseaseSECTION D The Eye37. Allergic Diseases of the EyeSECTION E Respiratory Tract38. The Nose and Control of Nasal Airflow39. Allergic and Nonallergic Rhinitis40. Rhinosinusitis and Nasal Polyps41. Development, Structure, and Physiology in Normal Lung and in Asthma42. Respiratory Tract Mucosal Immunology43. Airway Mucus and the Mucociliary System44. Epidemiology of Asthma and Allergic Diseases45. Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma46. Climate Change: Allergic Diseases and Asthma47. Mouse Models of Allergic Airways Disease48. Diagnosis of Asthma in Infants and Children49. Management of Asthma in Infants and Children50. Diagnosis of Asthma in Adults51. Management of Asthma in Adolescents and Adults52. Emergency Treatment and Approach to the Patient With Acute Asthma53. Approach to the Patient With Exercise-Induced Bronchoconstriction54. Asthma and Allergic Diseases During Pregnancy55. Occupational Allergy and Asthma56. Pathology of Asthma57. Allergic Bronchopulmonary Aspergillosis, Hypersensitivity Pneumonitis, and Epidemic Thunderstorm Asthma58. Immunologic Nonasthmatic Diseases of the Lung59. Approaches to the Patient With Chronic Cough60. Bronchial and Nasal Challenge Testing61. Lung Imaging62. Pharmaceutical Aerosols and Aerosol Drug Delivery SystemsVOLUME 2SECTION F Gastrointestinal Tract63. Gastrointestinal Mucosal Immunology64. Eosinophilic Gastrointestinal DisordersSECTION G Systemic Disease65. Clinical Significance of Immunoglobulin E66. In Vivo Methods for the Study and Diagnosis of IgE-Mediated Allergy67. Approach to the Patient With Recurrent Infections68. Primary Immunodeficiency Diseases69. Treatment of Primary Immunodeficiency Diseases70. HIV Infection and Allergic Disease71. Laboratory Tests for Allergic and Immunodeficiency Diseases72. Eosinophilia and Eosinophil-Related Disorders73. Mastocytosis74. Anaphylaxis75. Insect Allergy76. Drug Allergy77. Hypersensitivity to Aspirin and Other Nonsteroidal Anti-inflammatory Drugs78. Reactions to Foods79. Oral Food Challenge Testing80. Food Allergy Management, Prevention, and Therapy81. Adverse Reactions to VaccinesSECTION H Therapeutics82. Allergen Immunotherapy for Inhalant Allergens83. Principles of Pharmacotherapeutics84. Precision Medicine in Allergic Disorders85. Optimizing Adherence in Practice86. Anti-Immunoglobulin E Therapy87. Cytokine-Specific Therapy in Asthma88. Histamine and Antihistamines89. Inhaled ?2-Agonists90. Anticholinergic Therapies91. Glucocorticoids92. Antileukotriene Therapy in Asthma93. Unconventional Theories and Unproven Methods in Allergy94. Complementary and Integrative HealthAppendix A: CD Molecules