Microglial Aging

Basic, Translational and Clinical Advances

Häftad, Engelska, 2026

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Beskrivning

Microglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves into the physiological roles of microglia, the effects of aging on their structure and activity, and their significance in age-related neurodegenerative diseases. With insights from basic, translational, and clinical studies, it provides a thorough understanding of microglial health and its impact on aging. The book discusses how lifestyle choices can enhance microglial functions and prevent neurodegenerative diseases. It covers both pharmacological and non-pharmacological approaches, such as the ketogenic diet, cannabinoids, psychedelics, and non-invasive vagal nerve stimulation.

This text is invaluable for researchers and clinicians focused on improving the quality of life for an aging population.

Covers basic, translational, and clinical research advances in microglial aging
Reviews the most up-to-date research findings on microglial aging and their implication in age-related neurodegenerative diseases
Includes current knowledge on the effects of lifestyle on microglial aging and on promising strategies, both pharmacological and non-pharmacological, for rejuvenating microglia

Produktinformation

Utgivningsdatum:2026-02-17
Mått:191 x 235 x 20 mm
Vikt:450 g
Format:Häftad
Språk:Engelska
Antal sidor:382
Förlag:Elsevier Science
ISBN:9780443273407

Utforska kategorier

Geriatrik inom Medicin
Fysiologi inom Medicin

Mer om författaren

Dr. Marie-Ève Tremblay is a Full Professor at the School of Medical Sciences, University of Victoria, British Columbia, Canada. She was awarded a Tier II Canada Research Chair in Neurobiology of Aging and Cognition until 2025. Dr. Tremblay is an internationally recognized leader in microglial research. Her career goal is to become a world leader in the development of innovative therapies normalizing microglial functions upon exposure to various environmental risk factors for disease throughout life. She has been invited to present her work over 143 times, at seminars, lectures at symposia, specialized courses, and other meetings. She has 182 publications cited 11,854 times, corresponding to an h-index of 50 and i10-index of 116 (Google Scholar). She was also named a Clarivate Highly Cited Researcher, being among the top 1% across fields in 2021 and 2022 and is ranked 4th world microglial expert by ExpertScape.

Innehållsförteckning

SECTION 1: Introduction to microglial aging and its involvement in neurodegenerative diseases1 Introduction to microglial aging and its involvement in neurodegenerative diseases2 Involvement of microglial aging in neurodegenerative diseases: a focus on Parkinson’s disease3 Involvement of microglial aging in neurodegenerative diseases: a focus on multiple sclerosis4 Involvement of microglial aging in neurodegenerative diseases: a focus on amyotrophic lateral sclerosisSECTION 2: Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory5 Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory: diet and the gut-brain axis6 Sleep disturbance as a modulator of microglial morphology and function: implications for neurodegenerative disease7 The effects of bacterial and viral infections on microglia8 Physical activity and microglial metabolism in neurodegenerative diseasesSECTION 3: Emerging treatment strategies to rejuvenate microglia in aging and neurodegenerative diseases9 Microglial senescence and senolytic drugs10 Cannabinoids as modulators for Alzheimer’s disease: a role for microglia?11 Psychedelics and microglia in aging: unraveling the secret dialogue behind healthy aging, mental health, and neuroinflammation12 Effects of plasmalogens on microglial function and neuroinflammation: mechanisms and implications in aging and neurodegenerative diseasesAppendix: EpilogueIndex