Dr. Marie-Ève Tremblay is a Full Professor at the School of Medical Sciences, University of Victoria, British Columbia, Canada. She was awarded a Tier II Canada Research Chair in Neurobiology of Aging and Cognition until 2025. Dr. Tremblay is an internationally recognized leader in microglial research. Her career goal is to become a world leader in the development of innovative therapies normalizing microglial functions upon exposure to various environmental risk factors for disease throughout life. She has been invited to present her work over 143 times, at seminars, lectures at symposia, specialized courses, and other meetings. She has 182 publications cited 11,854 times, corresponding to an h-index of 50 and i10-index of 116 (Google Scholar). She was also named a Clarivate Highly Cited Researcher, being among the top 1% across fields in 2021 and 2022 and is ranked 4th world microglial expert by ExpertScape.

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• SECTION 1: Introduction to microglial aging and its involvement in neurodegenerative diseases1 Introduction to microglial aging and its involvement in neurodegenerative diseases2 Involvement of microglial aging in neurodegenerative diseases: a focus on Parkinson’s disease3 Involvement of microglial aging in neurodegenerative diseases: a focus on multiple sclerosis4 Involvement of microglial aging in neurodegenerative diseases: a focus on amyotrophic lateral sclerosisSECTION 2: Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory5 Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory: diet and the gut-brain axis6 Sleep disturbance as a modulator of microglial morphology and function: implications for neurodegenerative disease7 The effects of bacterial and viral infections on microglia8 Physical activity and microglial metabolism in neurodegenerative diseasesSECTION 3: Emerging treatment strategies to rejuvenate microglia in aging and neurodegenerative diseases9 Microglial senescence and senolytic drugs10 Cannabinoids as modulators for Alzheimer’s disease: a role for microglia?11 Psychedelics and microglia in aging: unraveling the secret dialogue behind healthy aging, mental health, and neuroinflammation12 Effects of plasmalogens on microglial function and neuroinflammation: mechanisms and implications in aging and neurodegenerative diseasesAppendix: EpilogueIndex