Abul K. Abbas, MBBS, Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California Andrew H. Lichtman is Professor of Pathology, Brigham and Women's Hospital, Harvard Medical School. Shiv Pillai is Professor of Medicine and Health Sciences and Technology, Harvard Medical School, Ragon Institute of MGH, MIT and Harvard. Sarah Henrickson is Assistant Professor, Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia Department of Pediatrics, Perelman School of Medicine Department of Microbiology, Perelman School of Medicine.

Review of the previous edition:“This is an excellent immunology textbook because it thoroughly dissects the fine developmental process of the immune system. It is well written and this edition’s illustrations are excellent.” --©Doody’s Review Service, 2022, Eric L. Brown, PhD (University of Texas Health Science Center at Houston) Doody’s Score: 92 - 4 Stars!

• 1. Overview of the Immune System2. Cells and Tissues of the Immune System3. Leukocyte Circulation and Migration Into Tissues4. Innate Immunity5. Antibodies and Antigens6. Antigen Presentation to T Lymphocytes and the Role of Major Histocompatibility Complex Molecules7. Immune Receptors and Signal Transduction8. Lymphocyte Development and Antigen Receptor Gene Rearrangement9. Activation and Regulation of T Lymphocytes10. Differentiation and Functions of CD4 + Effector T Cells11. Differentiation and Functions of CD8 + Effector T Cells12. B-Cell Activation and Antibody Production13. Effector Mechanisms of Humoral Immunity14. Specialized Immunity at Epithelial Barriers and in Immune-Privileged Tissues15. Immunologic Tolerance and Autoimmunity16. Immunity to Microbes17. Transplantation Immunology18. Tumor Immunology19. Hypersensitivity Disorders20. Allergy21. Congenital and Acquired Immunodeficiencies