Immuno-oncology and Immunotherapy Part E

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience. Norma received her master’s degree in health biology from Paris Saclay. In 2013, she joined the laboratory of Dr. Guido Kroemer at the Centre de Recherche des Cordeliers (Paris, France) and at Gustave Roussy (Villejuif, France), the largest center for oncological patients in Europe. She worked on several projects linked to immunosurveillance, culminating with her obtaining her PhD in 2017 with an original work on “Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance”. She then moved to Weill Cornell Medicine to join the program in radiation and immunity under the mentorship of Dr. Galluzzi. Her current research is focused on investigating resistance to immunotherapy in a mouse model of HR+ breast cancer.Maud Charpentier received her M.Sc. in Cellular Biology and her Ph.D. in Immunology from the University of Nantes, France. She chose to pursue an academic career and continued her postdoctoral training in the United States. She joined the Department of Radiation Oncology at Weill Cornell Medicine under the mentorship of Dr. Sandra Demaria. Maud has a long-standing interest in the anti-tumor immune response and its role in controlling cancer progression and treatment outcomes. Her research focuses on understanding the synergy between radiation therapy and immunotherapy in solid tumors, with the aim of overcoming resistance to treatment and developing innovative therapeutic approaches in preclinical models. Jose Manuel Bravo-San Pedro is currently a researcher at the Department of Physiology of the Complutense University of Madrid thanks to a Ramon y Cajal contract grant. He got his Ph.D. in biochemistry, cellular biology and genetics from the University of Extremadura (Caceres, Spain) in 2011, and he did a post-doctoral stage in the laboratory of Prof. Guido Kroemer. His main research interests have always been linked to autophagy, addressing this cellular process associated with neurodegenerative diseases or cancer and recently obesity and specifically related to problems in the correct functioning of the cilium. He is co-inventor of two patents and co-author of 110 publications indexed in PubMed in prestigious international journals, with h-index 45 and 23768 cites (Dec 2022).

• 1. Evaluation of agents that affect anti-tumor function of CD8+ T cells at activationDouglas McNeel2. Cancer cyro-immunotherapy: Models and methodsGeorge Prendergast3. Methods for analysis of cancer- and TLS-associated immune infiltrates by multiplex immunofluorescence histologyIleana Mauldin and Leon Zheng4. In-vivo measurement of the extracellular ATP concentration by bio-luminescent probesMario Tarantini, Anna Lisa GIULIANI, Valentina Vultaggio-Poma, Simonetta Falzoni, Elena Adinolfi and Francesco Di Virgilio5. Analysis of the tumor microenvironment using imaging mass cytometry dataZlatko Trajanoski and Zuzana Loncova6. Saphenous vein blood collection for different immune analyses of living miceAna Carolina Martinez Torres, Kenny Misael Calvillo-Rodriguez, Reyes Tamez-Guerra, Cristina Rodriguez-Padilla and Kassandra Ofelia Rodriguez-Aguillon7. Use of mouse KO models to validate the specificity of monoclonal antibodiesGeorge Prendergast, Lisa D. Laury-Kleintop, Summer Sedano and Kaylend Manley8. Imaging mass cytometry to analyze the immune TMELouis M. Weiner9. Autoimmune arthritis: Transgenic mouse models and methodsLaura Mandik-Nayak, Lauren Merlo and Weidan Peng10. Assessment of human and mouse tumor-antigen specific CD8+ T cells by multimer staining in multiple compartmentsMaha Ayyoub, Clara Maria SCARLATA, Virginie Feliu and Christel Devaud11. Generation and functional evaluation of bispecific antibodiesLuis Alvarez-Vallina, Antonio Tapia Galisteo, Anaïs Jiménez-Reinoso, Rodrigo Lázaro Gorines and Belén Blanco12. Isolation and phenotype analysis of intraepithelial lymphocytes from the mouse colonLaura Bracci, Alessia Fiore, Michela Tozzi, Paola Rinzo, Daniele Macchia, Massimo Spada and Alessia Fabbri13. Analysis of single cell TCR repertoires and gene expression from multi-modal scRNA-seq dataDietmar Rieder, Christina Plattner and Gregor Sturm14. Analysis of the tumor immune microenvironment of brain tumors by flow-cytometryClaire I. Vanpouille-Box15. Assessment of in vitro interactions between eosinophils and cancer cells by imaging-enhanced flow cytometry and time-lapse microscopy.Fabrizio Mattei, Giovanna Schiavoni, Caterina Antonucci, Adriana Rosa Gambardella and Valentina Tirelli16. Pharmacological screening to identify potential regulators of antigen presentation by dendritic cellsPeng LIU, Liwei Zhao, Guido Kroemer, Oliver Kepp, Yuhong Pan and Shuai Zhang