In this issue of Radiologic Clinics, guest editors Drs. Giuseppe Guglielmi and Alberto Bazzocchi bring their considerable expertise to the topic of Musculoskeletal Interventional Radiology. Top experts discuss interventional procedures in rheumatology, regenerative medicine, metabolic bone diseases, and more, as well as tips and tricks for fluoro-guided procedures, fluoroscopy-guided and intravascular procedures, ultrasound-guided procedures, CT-guided procedures, and MR-guided procedures.