Chalcones

Dr. Carradori is a very prolific researcher with papers dealing with both synthetic and natural products characterized by promising biological activities. Regarding this topic, he has been involved in the study of HAT inhibitors, hCA IX and XII inhibitors, kinesin Eg5 inhibitors and natural compounds active in the field of oncology. Recently, he has been focusing on “drug repurposing” disclosing a patent on new roles played by antiparasitic benzimidazoles as anti-cancer agents. He also was Co-Guest Editor of several special issues, co-author of chapters for two books (one edited by Elsevier) and acts as Editorial Board member of several peer-reviewed journals. Dr. Moi Davide is a researcher involved in the design, synthesis, and characterization of small molecules endowed with promising biological activity. He is mainly involved in the study of compounds with multitarget activity in the cancer field, as well as in the study of epigenetic modulators, such as HDACs and Carbonic Anhydrase modulators. In the last years, he has been involved in the synthesis of high-value scaffolds through photo- and organo-catalysis, as well as in the development of fluorescent molecules for bio-imaging. He is also the author of several research articles and, Guest and Co-Guest editor of different special issues.Dr. Ilaria D’Agostino is a medicinal chemist involved in the development of small molecules as putative anticancer, antifibrotic, and antiinfective agents and hybrid compounds for a multitarget approach. Currently, she is mainly involved in the design and synthesis of compounds targeting cancer stem cells for an antitumoral application along with innovative targeted theranostic agents for precision medicine. She is the author of several research articles and book chapters, and Co-Guest editor of different special issues.

• Part I - Foundations of Chalcones research1. Natural sources of Chalcones2. Extraction methods from traditional to green approaches3. Structural and spectroscopic characterization of Chalcones4. Synthesis, structural modifications and scale-up methods5. Medicinal Chemistry Strategies in the Chalcone scaffold6. Chalcones as versatile intermediates in organic chemistry7. Chalcones in metal complexesPart II – Pharmacology of Chalcones8. PK properties and bioavailability of Chalcones9. Chalcone Toxicity10. Natural Chalcones in Traditional Medicine11. Chalcones as Antiviral Agents12. Chalcones as Antibacterial and Antitubercular Agents13. Anticancer Potential of Chalcones14. Chalcones as Neuroprotective and Anti-Alzheimer’s Disease Agents15. Chalcones as Antiprotozoal, Antiparasitic and Insecticidal Agents16. Chalcones as Antifungal Agents17. Chalcones as Anti-inflammatory, Anti-ulcer and Antioxidant Agents18. Chalcones as Anti-hyperlipidemic, Anti-diabetic and Insulin Regulating AgentsPart III – Prospects19. Chalcone-containing Products (food supplements, nutraceuticals, functional food)20. Formulations and Drug Delivery of Chalcones21. Chalcone-protein co-crystals in the PDB22. Clinical Trials of Chalcone-based drug candidates