In this issue of Facial Plastic Surgery Clinics, guest editors Drs. Richard D. Gentile and Brian J. Wong bring their considerable expertise to the topic of Skin Rejuvenation: Old, New, and Next. Top experts offer a comprehensive look at the evolving landscape of skin and hair rejuvenation, from foundational techniques like chemexfoliation to next-generation biologics such as exosome therapies and platelet-rich plasma. This issue delivers actionable insights grounded in science and clinical experience, covering topics such as synergistic protocols that combine plasma skin rejuvenation with conventional laser modalities, how PICO technology is redefining scar revision and tattoo clearance, optimizing outcomes in challenging areas like the neck with energy-based devices, and much more-equipping surgeons with the tools to expand their aesthetic repertoire and deliver transformative results with precision and confidence.