In this issue of Clinics in Plastic Surgery, guest editors Drs. Jesse A. Goldstein and Francesco Egro bring their considerable expertise to the topic of Artificial Intelligence in Plastic Surgery. Top experts explore the breadth and depth of AI’s impact on plastic surgery, from foundational principles to ethical issues, advanced clinical applications in all plastic surgery sub-specialties, and the use of AI in research and clinical practice. Together, these sections showcase how AI is not replacing surgical judgment but enhancing it, empowering surgeons to deliver more individualized, data-informed, and effective care