In this issue of Infectious Disease Clinics of North America, guest editors Drs. Aruna Subramanian, Jennifer Ferguson, and Joanna Nelson bring their considerable expertise to the topic of Infections Related to Biologics. In this first-of-its-kind issue, top experts first discuss biologics based on the disease area for which they are used, covering infectious disease risks along with strategies for screening and monitoring for these risks. Articles then provide an overview of the bacterial, viral, fungal, and mycobacterial infections that are potentiated by biologics, and discuss recommended vaccinations and prophylaxis strategies to prevent these infections.