In this issue of PET Clinics, guest editor Dr. Rakesh Kumar brings his considerable expertise to the topic of Applications of FDG-PET Imaging in the Management of Patients with Various Malignancies. This issue is the second of four that describes the revolutionary impact of FDG-PET on the day-to-day practice of medicine during the past five decades. Top experts discuss key topics in the areas imaging metabolically active tumors and providing both functional and anatomic information to guide cancer management.