Nuklearmedicin

This textbook summarizes the basic knowledge of atomic, nuclear, and radiation physics that professionals working in medical physics and biomedical engineering need for efficient and safe use of ionizing radiation in medicine. Concentrating on the underlying principles of radiation physics, the textbook covers the prerequisite knowledge for medical physics courses on the graduate and post-graduate levels in radiotherapy physics, radiation dosimetry, imaging physics, and health physics, thus providing the link between elementary undergraduate physics and the intricacies of four medical physics specialties: diagnostic radiology physics, nuclear medicine physics, radiation oncology physics, and health physics. To recognize the importance of radiation dosimetry to medical physics three new chapters have been added to the 14 chapters of the previous edition. Chapter 15 provides a general introduction to radiation dosimetry. Chapter 16 deals with absolute radiation dosimetry systems that establish absorbed dose or some other dose related quantity directly from the signal measured by the dosimeter. Three absolute dosimetry techniques are known and described in detail: (i) calorimetric; (ii) chemical (Fricke), and (iii) ionometric. Chapter 17 deals with relative radiation dosimetry systems that rely on a previous dosimeter calibration in a known radiation field. Many relative radiation dosimetry systems have been developed to date and four most important categories used routinely in medicine and radiation protection are described in this chapter: (i) Ionometric dosimetry; (ii) Luminescence dosimetry; (iii) Semiconductor dosimetry; and (iv) Film dosimetry.The book is intended as a textbook for a radiation physics course in academic medical physics graduate programs as well as a reference book for candidates preparing for certification examinations in medical physics sub-specialties. It may also be of interest to many professionals, not only physicists, who in their daily occupations deal with various aspects of medical physics or radiation physics and have a need or desire to improve their understanding of radiation physics.

Jan Waldenström (1906-1996) was the leading Swedish internist of the twentieth century. The first chapter of the book presents his remarkable family including five generations of physicians. Born in Stockholm, we follow JW to medical school at Uppsala University during 1924–33. In 1934–5, he spent a year in the laboratory of Nobel Laureate Hans Fischer in Munich. In 1937, he defended a landmark thesis on acute intermittent porphyria. As “Docent” (assistant professor) in Uppsala, he discovered two new diseases in 1943, one of which was macroglobulinemia. In 1944–5, he spent 7 months in the US commissioned by the Swedish Health Board. This started friendships and interactions with leading colleagues and scientists. With time, JW fostered a worldwide network of contacts and became a most influential international authority. But this was just the beginning. The book follows Waldenström's remarkable career including his description of chronic active hepatitis as a new disease and the carcinoid syndrome. Among his many other significant achievements were the introduction of nuclear medicine in Sweden and his pioneering the concept of poly- and monoclonal gammopathies. His legacy is emphasized by Waldenström lectures, Waldenström Prizes, and by the International Waldenström’s Macroglobulinemia Foundation, IWMF, and the Bing Center for Waldenström’s macroglobulinemia at the Dana Farber Institute of Cancer Institute of the Harvard University in Boston. And  now, not least, by this comprehensive biography.

Dava Sobel, acclaimed and bestselling author of Longitude, chronicles the life and work of the most famous woman in the history of science – and the untold story of the young women who trained in her laboratory. ‘A fresh and feminist study of the pioneering Nobel laureate reveals her impact on the women she mentored and set on the path to prominence’ Observer ‘It is a novel lens through which to view Curie’s story, and Sobel paints her tale with characteristic deftness and eloquence’ Financial Times For decades Marie Curie was the only woman in the room at international scientific gatherings, and despite constant illness she travelled far and wide to share the secrets of radioactivity, a term she coined. She is still the only person to win a Nobel Prize in two scientific fields.Her ingenuity extended far beyond the laboratory walls; grieving the death of her husband, Pierre, she took his place as professor of physics at the Sorbonne, devotedly raised two daughters, drove a van she outfitted with X-ray equipment to the front lines of World War I, befriended Albert Einstein and inspired generations of young women to pursue science as a way of life.Approaching Marie Curie from a unique angle, Sobel navigates her remarkable discoveries and fame alongside the women who became her legacy – from Norway’s Ellen Gleditsch and France’s Marguerite Perry, who discovered the element francium, to her own daughter, Irene, a Nobel Prize winner in her own right. The Elements of Marie Curie deftly illuminates the trailblazing life and enduring influence of one of the most consequential figures of our time. ‘A lucid, literate biography, celebrating a scientific exemplar who, for all her fame, deserves to be better known’ Kirkus ‘As expected from a Pulitzer Prize finalist, Sobel writes beautifully and with clarity about the science that Curie specialised in, making clear the achievements that her lab brought about’ Daily Mail ‘This is an essential read, capturing both [Curie's] genius and her legacy’ New Scientist ‘Sobel’s book is a luminous and illuminating contribution to the cause’ Literary Review

Widely regarded as the cornerstone text in the field, the successful series of editions continues to follow the tradition of a clear and comprehensive presentation of the physical principles and operational aspects of medical imaging.  The Essential Physics of Medical Imaging, 4th Edition, is a coherent and thorough compendium of the fundamental principles of the physics, radiation protection, and radiation biology that underlie the practice and profession of medical imaging. Distinguished scientists and educators from the University of California, Davis, provide up-to-date, readable information on the production, characteristics, and interactions of non-ionizing and ionizing radiation, magnetic fields and ultrasound used in medical imaging and the imaging modalities in which they are used, including radiography, mammography, fluoroscopy, computed tomography, magnetic resonance, ultrasound, and nuclear medicine. This vibrant, full-color text is enhanced by more than 1,000 images, charts, and graphs, including hundreds of new illustrations. This text is a must-have resource for medical imaging professionals, radiology residents who are preparing for Core Exams, and teachers and students in medical physics and biomedical engineering.   Features a new introductory overview, plus new information on informatics-oriented concepts, multisource and other x-ray tubes, new quality control procedures for digital radiography, digital breast tomosynthesis, dedicated breast CT, best practices in minimizing fluoroscopy dose to patients and staff, dosimetry in x-ray imaging, 3T and 7T MRI, MR artifacts and solutions, ultrasound elastography, nuclear cardiology,  total-body PET imaging, and much more.Provides clear but detailed explanations of the basic science important to nuclear imaging, including the physical properties and production of radioactivity, radiation detection and measurement and completely updated chapters on radiopharmaceuticals and internal dosimetry, SPECT and PET/CT.Addresses topics common to all forms of diagnostic imaging, including image quality and medical informatics as well as the non-ionizing medical imaging modalities of MRI and ultrasound.Introduces a completely updated radiation biology section with current concepts in biological effects at the molecular, cellular and organ systems levels as well as the acute radiation syndrome and the latest assessment of potential biological effects to the fetus, children and adults from medical imaging procedures, as well as principles for effective risk communication.Updates the radiation protection section relevant to all aspects of medical imaging to the latest concepts in patient and staff protection, including current Joint Commission and regulatory quality assurance requirements, as well as radiological emergency medical management.

This open access textbook focuses on the various aspects of radiobiology. The goal of radiobiological research is to better understand the effects of radiation exposure at the cellular and molecular levels in order to determine the impact on health. This book offers a unique perspective, by covering not only radiation biology but also radiation physics, radiation oncology, radiotherapy, radiochemistry, radiopharmacy, nuclear medicine, space radiation biology & physics, environmental and human radiation protection, nuclear emergency planning, molecular biology and bioinformatics, as well as the ethical, legal and social considerations related to radiobiology. This range of disciplines contributes to making radiobiology a broad and rather complex topic. This textbook is intended to provide a solid foundation to those interested in the basics and practice of radiobiological science. It is a learning resource, meeting the needs of students, scientists and medical staff with an interest in this rapidly evolving discipline, as well as a teaching tool, with accompanying teaching material to help educators.

Dava Sobel, acclaimed and bestselling author of Longitude, chronicles the life and work of the most famous woman in the history of science – and the untold story of the young women who trained in her laboratory. ‘A fresh and feminist study of the pioneering Nobel laureate reveals her impact on the women she mentored and set on the path to prominence’ Observer ‘It is a novel lens through which to view Curie’s story, and Sobel paints her tale with characteristic deftness and eloquence’ Financial Times For decades Marie Curie was the only woman in the room at international scientific gatherings, and despite constant illness she travelled far and wide to share the secrets of radioactivity, a term she coined. She is still the only person to win a Nobel Prize in two scientific fields.Her ingenuity extended far beyond the laboratory walls; grieving the death of her husband, Pierre, she took his place as professor of physics at the Sorbonne, devotedly raised two daughters, drove a van she outfitted with X-ray equipment to the front lines of World War I, befriended Albert Einstein and inspired generations of young women to pursue science as a way of life.Approaching Marie Curie from a unique angle, Sobel navigates her remarkable discoveries and fame alongside the women who became her legacy – from Norway’s Ellen Gleditsch and France’s Marguerite Perry, who discovered the element francium, to her own daughter, Irene, a Nobel Prize winner in her own right. The Elements of Marie Curie deftly illuminates the trailblazing life and enduring influence of one of the most consequential figures of our time. ‘A lucid, literate biography, celebrating a scientific exemplar who, for all her fame, deserves to be better known’ Kirkus ‘As expected from a Pulitzer Prize finalist, Sobel writes beautifully and with clarity about the science that Curie specialised in, making clear the achievements that her lab brought about’ Daily Mail ‘This is an essential read, capturing both [Curie's] genius and her legacy’ New Scientist ‘Sobel’s book is a luminous and illuminating contribution to the cause’ Literary Review

Dava Sobel, acclaimed and bestselling author of Longitude, chronicles the life and work of the most famous woman in the history of science – and the untold story of the young women who trained in her laboratory. ‘A fresh and feminist study of the pioneering Nobel laureate reveals her impact on the women she mentored and set on the path to prominence’ Observer ‘It is a novel lens through which to view Curie’s story, and Sobel paints her tale with characteristic deftness and eloquence’ Financial Times For decades Marie Curie was the only woman in the room at international scientific gatherings, and despite constant illness she travelled far and wide to share the secrets of radioactivity, a term she coined. She is still the only person to win a Nobel Prize in two scientific fields.Her ingenuity extended far beyond the laboratory walls; grieving the death of her husband, Pierre, she took his place as professor of physics at the Sorbonne, devotedly raised two daughters, drove a van she outfitted with X-ray equipment to the front lines of World War I, befriended Albert Einstein and inspired generations of young women to pursue science as a way of life.Approaching Marie Curie from a unique angle, Sobel navigates her remarkable discoveries and fame alongside the women who became her legacy – from Norway’s Ellen Gleditsch and France’s Marguerite Perry, who discovered the element francium, to her own daughter, Irene, a Nobel Prize winner in her own right. The Elements of Marie Curie deftly illuminates the trailblazing life and enduring influence of one of the most consequential figures of our time. ‘A lucid, literate biography, celebrating a scientific exemplar who, for all her fame, deserves to be better known’ Kirkus ‘As expected from a Pulitzer Prize finalist, Sobel writes beautifully and with clarity about the science that Curie specialised in, making clear the achievements that her lab brought about’ Daily Mail ‘This is an essential read, capturing both [Curie's] genius and her legacy’ New Scientist ‘Sobel’s book is a luminous and illuminating contribution to the cause’ Literary Review

Dava Sobel, acclaimed and bestselling author of Longitude, chronicles the life and work of the most famous woman in the history of science – and the untold story of the young women who trained in her laboratory. ‘A fresh and feminist study of the pioneering Nobel laureate reveals her impact on the women she mentored and set on the path to prominence’ Observer ‘It is a novel lens through which to view Curie’s story, and Sobel paints her tale with characteristic deftness and eloquence’ Financial Times For decades Marie Curie was the only woman in the room at international scientific gatherings, and despite constant illness she travelled far and wide to share the secrets of radioactivity, a term she coined. She is still the only person to win a Nobel Prize in two scientific fields.Her ingenuity extended far beyond the laboratory walls; grieving the death of her husband, Pierre, she took his place as professor of physics at the Sorbonne, devotedly raised two daughters, drove a van she outfitted with X-ray equipment to the front lines of World War I, befriended Albert Einstein and inspired generations of young women to pursue science as a way of life.Approaching Marie Curie from a unique angle, Sobel navigates her remarkable discoveries and fame alongside the women who became her legacy – from Norway’s Ellen Gleditsch and France’s Marguerite Perry, who discovered the element francium, to her own daughter, Irene, a Nobel Prize winner in her own right. The Elements of Marie Curie deftly illuminates the trailblazing life and enduring influence of one of the most consequential figures of our time. ‘A lucid, literate biography, celebrating a scientific exemplar who, for all her fame, deserves to be better known’ Kirkus ‘As expected from a Pulitzer Prize finalist, Sobel writes beautifully and with clarity about the science that Curie specialised in, making clear the achievements that her lab brought about’ Daily Mail ‘This is an essential read, capturing both [Curie's] genius and her legacy’ New Scientist ‘Sobel’s book is a luminous and illuminating contribution to the cause’ Literary Review

Dava Sobel, acclaimed and bestselling author of Longitude, chronicles the life and work of the most famous woman in the history of science – and the untold story of the young women who trained in her laboratory.‘A fresh and feminist study of the pioneering Nobel laureate reveals her impact on the women she mentored and set on the path to prominence’ Observer‘It is a novel lens through which to view Curie’s story, and Sobel paints her tale with characteristic deftness and eloquence’ Financial TimesFor decades Marie Curie was the only woman in the room at international scientific gatherings, and despite constant illness she travelled far and wide to share the secrets of radioactivity, a term she coined. She is still the only person to win a Nobel Prize in two scientific fields.Her ingenuity extended far beyond the laboratory walls; grieving the death of her husband, Pierre, she took his place as professor of physics at the Sorbonne, devotedly raised two daughters, drove a van she outfitted with x-ray equipment to the front lines of World War I, befriended Albert Einstein and inspired generations of young women to pursue science as a way of life.Approaching Marie Curie from a unique angle, Sobel navigates her remarkable discoveries and fame alongside the women who became her legacy – from Norway’s Ellen Gleditsch and France’s Marguerite Perry, who discovered the element francium, to her own daughter, Irene, a Nobel Prize winner in her own right. The Elements of Marie Curie deftly illuminates the trailblazing life and enduring influence of one of the most consequential figures of our time.‘A lucid, literate biography, celebrating a scientific exemplar who, for all her fame, deserves to be better known’Kirkus‘As expected from a Pulitzer Prize finalist, Sobel writes beautifully and with clarity about the science that Curie specialised in, making clear the achievements that her lab brought about’ Daily Mail‘This is an essential read, capturing both [Curie''s] genius and her legacy’ New Scientist‘Sobel’s book is a luminous and illuminating contribution to the cause’ Literary Review

Dava Sobel, acclaimed and bestselling author of Longitude, chronicles the life and work of the most famous woman in the history of science – and the untold story of the young women who trained in her laboratory.‘A fresh and feminist study of the pioneering Nobel laureate reveals her impact on the women she mentored and set on the path to prominence’ Observer‘It is a novel lens through which to view Curie’s story, and Sobel paints her tale with characteristic deftness and eloquence’ Financial TimesFor decades Marie Curie was the only woman in the room at international scientific gatherings, and despite constant illness she travelled far and wide to share the secrets of radioactivity, a term she coined. She is still the only person to win a Nobel Prize in two scientific fields.Her ingenuity extended far beyond the laboratory walls; grieving the death of her husband, Pierre, she took his place as professor of physics at the Sorbonne, devotedly raised two daughters, drove a van she outfitted with X-ray equipment to the front lines of World War I, befriended Albert Einstein and inspired generations of young women to pursue science as a way of life.Approaching Marie Curie from a unique angle, Sobel navigates her remarkable discoveries and fame alongside the women who became her legacy – from Norway’s Ellen Gleditsch and France’s Marguerite Perry, who discovered the element francium, to her own daughter, Irene, a Nobel Prize winner in her own right. The Elements of Marie Curie deftly illuminates the trailblazing life and enduring influence of one of the most consequential figures of our time.‘A lucid, literate biography, celebrating a scientific exemplar who, for all her fame, deserves to be better known’Kirkus‘As expected from a Pulitzer Prize finalist, Sobel writes beautifully and with clarity about the science that Curie specialised in, making clear the achievements that her lab brought about’ Daily Mail‘This is an essential read, capturing both [Curie''s] genius and her legacy’ New Scientist‘Sobel’s book is a luminous and illuminating contribution to the cause’ Literary Review

A subject index and a comprehensive index of radionuclides considered in all parts and supplements of ICRP Publication 30.

This report is a revision of ICRP Publication No 13. The recommendations it contains apply to the protection of pupils/students from ionizing radiation. They apply mainly to the teaching of natural science at secondary level, but they may be adapted to some forms of tertiary education.

This report provides guidance on the application of the ICRP system of radiological protection to prolonged exposure situations effecting members of the public. It addresses the general application of the Commission′s system to the control of prolonged exposures resulting from practices and to the undertaking of interventions in prolonged exposure situations. Additionally, it provides recommendations on generic reference levels for such interventions. The report also considers some specific situations and discusses a number of issues that have been of concern, namely: natural radiation sources that may give rise to high doses; the restoration and rehabilitation of sites where human activities involving radioactive substances have been carried out; the return to `normality′ following an accident that has released radioactive substances to the environment; and the global marketing of commodities for public consumption that contain radioactive substances. Annexes provide some examples of prolonged exposure situations and discuss the radiological protection quantities, radiation-induced health effects and aspects of the Commission′s system of radiological protection relevant to prolonged exposure.

Percutaneous Surgery of the Upper Urinary Tract: Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies.

In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine.

As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows as well as those teaching in the field.

Offers review content for urologists in training and "refresher� content for experts in endourology Explores new surgical techniques and technology through review-level content and extensive images of pathologies Includes over 500 images per volume; images taken from more than 4000 endourologic procedures performed annually at the editor's hospital

Nuclear cardiac imaging refers to cardiac radiological diagnostic techniques performed with the aid of radiopharmaceuticals, which are perfused into the myocardium as markers. These imaging studies provide a wide range of information about the heart, including the contractility of the heart, the amount of blood supply to the heart and whether parts of the heart muscle are alive or dead. This is essential information for cardiologists, and nuclear imaging has become an increasingly important part of the cardiologist's armamentarium. Chapters in Nuclear Cardiac Imaging cover historical, technical and physiological considerations, diagnosis and prognosis, conditions other than Coronary Artery Disease (CAD), advanced cardiac imaging, and challenges and opportunities. New to the sixth edition are key point summaries at the start of each chapter, clinical cases with videos, and a question and answer chapter on practical issues. This volume is ideal for nuclear cardiologists in training and nuclear clinicians alike who are searching for quick answers to important clinical and technical questions.

Nuclear cardiac imaging refers to cardiac radiological diagnostic techniques performed with the aid of radiopharmaceuticals, which are perfused into the myocardium as markers. These imaging studies provide a wide range of information about the heart, including the contractility of the heart, the amount of blood supply to the heart and whether parts of the heart muscle are alive or dead. This is essential information for cardiologists, and nuclear imaging has become an increasingly important part of the cardiologist''s armamentarium. Chapters in Nuclear Cardiac Imaging cover historical, technical and physiological considerations, diagnosis and prognosis, conditions other than Coronary Artery Disease (CAD), advanced cardiac imaging, and challenges and opportunities. New to the sixth edition are key point summaries at the start of each chapter, clinical cases with videos, and a question and answer chapter on practical issues. This volume is ideal for nuclear cardiologists in training and nuclear clinicians alike who are searching for quick answers to important clinical and technical questions.

Nuclear cardiac imaging refers to cardiac radiological diagnostic techniques performed with the aid of radiopharmaceuticals, which are perfused into the myocardium as markers. These imaging studies provide a wide range of information about the heart, including the contractility of the heart, the amount of blood supply to the heart and whether parts of the heart muscle are alive or dead. This is essential information for cardiologists, and nuclear imaging has become an increasingly important part of the cardiologist''s armamentarium. Chapters in Nuclear Cardiac Imaging cover historical, technical and physiological considerations, diagnosis and prognosis, conditions other than Coronary Artery Disease (CAD), advanced cardiac imaging, and challenges and opportunities. New to the sixth edition are key point summaries at the start of each chapter, clinical cases with videos, and a question and answer chapter on practical issues. This volume is ideal for nuclear cardiologists in training and nuclear clinicians alike who are searching for quick answers to important clinical and technical questions.

Neurological history claims its earliest origins in the 17th century with Thomas Willis's publication of Anatomy of the Brain, coming fully into fruition as a field in the late 1850s as medical technology and advancements allowed for in depth study of the brain. However, many of the foundations in neurology can find the seed of their beginning to a time much earlier than that, to ancient Greece in fact. Neurological Concepts in Ancient Greek Medicine is a collection of essays exploring neurological ideas between the Archaic and Hellenistic eras. These essays also provide historic, intellectual, and cultural context to ancient Greek medical practice and emphasizing the interest in the brain of the early physicians. This book describes source material that is over 2,500 years old and reveals the observational skills of ancient physicians. It provides complete translations of two historic Hippocratic texts: On the Sacred Diseases and On the Wounds of the Head. The book also discusses the Hippocratic Oath and the modern applications of its meaning. Dr. Walshe connects this ancient history, usually buried in medical histories, and shows the ancient Greek notions that are the precursors of our understanding of the brain and nervous system.

The neuron doctrine, first formulated in 1891, states that the brain is constructed of individual neurons, organized into functioning circuits that mediate behavior. Above all else, this is the main concept that underlies all of modern neuroscience. This 25th Aniversary Edition of The Foundations of the Neuron Doctrine explains how this theory was the product of an explosion of histological studies and vigorous debates near the end of the nineteenth century by an extraordinary group of scientists, most importantly the leading figure of the time, Santiago Ramon y Cajal of Spain, and includes the foremost nervous system investigators of many countries, such as Albrecht Kolliker, Sigmund Freud, Wilhelm His, August Forel, Fritdjof Nansen and Gustav Retzius. The neuron doctrine explains how these eminent scientists used a selective nerve cell stain invented by Camillo Golgi of Italy and followed him in describing the fabulous branching patterns of nerve cells, providing strong evidence that the cells interact as individual units to form circuits. This work also describes how this view was opposed by Golgi, who maintained that the nerve cells form syncytial networks. Studies in the 1950s appeared resoundingly to confirm the nerve cell as an individual unit, as embodied in the neuron doctrine, which became the basis for the rise of concepts of normal and disordered neural function in the remaining 20th century. This 25th Anniversary Edition concludes by discussing how recent studies are showing a much greater degree of complexity in neuronal organization, so that the debate of neuron versus network is again coming to the fore of neuroscience research. Unique to this anniversary edition is the inclusion of commentaries by distinguished leaders in the neurosciences on the continuing relevance of the neuron doctrine for modern studies of the brain at all levels, from genes and molecules to microcircuits, neural networks, and behavior.

The neuron doctrine, first formulated in 1891, states that the brain is constructed of individual neurons, organized into functioning circuits that mediate behavior. It is the fundamental principal that underlies all of neuroscience and clinical neurology. Foundations of the Neuron Doctrine gives an authoritative account of how this theory was the product of an explosion of histological studies and vigorous debates near the end of the nineteenth century by an extraordinary group of scientists, led by Santiago Ramon y Cajal of Spain, using a selective stain discovered by Camillo Golgi of Italy. They were the first to describe the distinctive branching patterns of nerve cells, providing evidence that the cells interact as individual units to form circuits, opposed however by Golgi, who held out for a view that the nerve cells form syncytial networks. Studies in the 1950s appeared to confirm the nerve cell as an individual unit, as embodied in the neuron doctrine, which became the basis for the rise of concepts of normal and disordered neural function since then. This 25th Anniversary Edition is timely. Recent studies are showing a much greater degree of complexity in neuronal organization, so that the debate of neuron versus network is again coming to the fore in neuroscience research. Unique to this Anniversary Edition is the inclusion of commentaries by distinguished international leaders - Marina Bentivoglio, Xavier De Felipe, Sten Grillner, Paolo Mazzarello, Larry Swanson, and Rafael Yuste - on the continuing relevance of the neuron doctrine for modern studies of the brain at all levels, from genes and molecules to microcircuits, neural networks, and behavior. As this new wave of modern studies expands our concepts of nervous function as the basis of behavior, Foundations of the Neuron Doctrine will be a unique source providing conceptual continuity from classical times to the present and into the future.With commentaries fromMarina Bentivoglio Paolo Mazzarello Javier DeFelipe Larry Swanson Sten Grillner Rafael Yuste

The neuron doctrine, first formulated in 1891, states that the brain is constructed of individual neurons, organized into functioning circuits that mediate behavior. It is the fundamental principal that underlies all of neuroscience and clinical neurology. Foundations of the Neuron Doctrine gives an authoritative account of how this theory was the product of an explosion of histological studies and vigorous debates near the end of the nineteenth century by an extraordinary group of scientists, led by Santiago Ramon y Cajal of Spain, using a selective stain discovered by Camillo Golgi of Italy. They were the first to describe the distinctive branching patterns of nerve cells, providing evidence that the cells interact as individual units to form circuits, opposed however by Golgi, who held out for a view that the nerve cells form syncytial networks. Studies in the 1950s appeared to confirm the nerve cell as an individual unit, as embodied in the neuron doctrine, which became the basis for the rise of concepts of normal and disordered neural function since then. This 25th Anniversary Edition is timely. Recent studies are showing a much greater degree of complexity in neuronal organization, so that the debate of neuron versus network is again coming to the fore in neuroscience research. Unique to this Anniversary Edition is the inclusion of commentaries by distinguished international leaders - Marina Bentivoglio, Xavier De Felipe, Sten Grillner, Paolo Mazzarello, Larry Swanson, and Rafael Yuste - on the continuing relevance of the neuron doctrine for modern studies of the brain at all levels, from genes and molecules to microcircuits, neural networks, and behavior. As this new wave of modern studies expands our concepts of nervous function as the basis of behavior, Foundations of the Neuron Doctrine will be a unique source providing conceptual continuity from classical times to the present and into the future.With commentaries fromMarina Bentivoglio Paolo Mazzarello Javier DeFelipe Larry Swanson Sten Grillner Rafael Yuste

In 194 cases featuring over 550, high-quality images, Nuclear Medicine and PET/CT Cases provides a succinct review of clinically relevant cases covering the full range of nuclear medicine. Cases are grouped into sections including: Nuclear CNS Imaging, Nuclear Inflammation/Infection Imaging, Ventilation/Perfusion Lung Scintigraphy, Pediatric Nuclear Medicine, Cardiac Imaging, Bone Scintigraphy, PET/CT in Oncology, General Oncologic Imaging, Thyroid and Parathyroid, Radionuclide Therapy and Pre-Therapy Evaluation, Liver, Spleen and Biliary Tract, Gastrointestinal Tract, Renal Scintigraphy. Part of the Cases in Radiology series, this book follows the easy-to-use format of question and answer in which the patient history is provided on the first page of the case, and radiologic findings, differential diagnosis, teaching points, next steps in management, and suggestions for furthering reading are revealed on the following page. This casebook is an essential resource for radiology residents and practicing radiologists alike.

Nuclear cardiac imaging refers to cardiac radiological diagnostic techniques performed with the aid of radiopharmaceuticals, which are perfused into the myocardium as markers. These imaging studies provide a wide range of information about the heart, including the contractility of the heart, the amount of blood supply to the heart and whether parts of the heart muscle are alive or dead. This is essential information for cardiologists, and nuclear imaging has become an increasingly important part of the cardiologist''s armamentarium. Chapters in Nuclear Cardiac Imaging cover historical, technical and physiological considerations, diagnosis and prognosis, conditions other than Coronary Artery Disease (CAD), advanced cardiac imaging, and challenges and opportunities. New to the fifth edition are key point summaries at the start of each chapter, clinical cases with videos, and a question and answer chapter on practical issues. This volume is ideal for nuclear cardiologists in training and nuclear clinicians alike who are searching for quick answers to important clinical and technical questions.

Readable, practical and concise, Nuclear Cardiology is a self-contained guide to this cardiac imaging subspecialty. Including both technical and clinical aspects, it provides a foundation of essential knowledge common to practitioners from any background.This title covers radiation physics, biology and protection, and addresses all areas of imaging including the design and operation of the gamma camera (including solid-state cameras), single photon emission computed tomography (SPECT) acquisition and processing, and image interpretation and writing of reports. Stress testing and radiopharmaceuticals are explained in detail, as is the evidence-base underpinning myocardial perfusion scintigraphy. Newer radionuclide imaging techniques are well-covered (e.g. phosphate scintigraphy in cardiac amyloidosis), as is the expanding field of cardiac positron emission tomography (PET).Fully updated with coverage of new indications for gamma camera imaging, increased focus on attenuation correction and SPECT-CT and detail on the design use and clinical implications of solid-state gamma cameras throughout, this second edition of the essential text for nuclear cardiology trainees and practitioners is fully illustrated with colour plates to aid clinical practice. Presented in the bestselling Oxford Specialist Handbook format, Nuclear Cardiology provides core knowledge for those training in the subspecialty, whether at a basic or advanced level or from a medical or technical background, and is a key resource for those seeking to accredit in the subspecialty.

Readable, practical and concise, Nuclear Cardiology is a self-contained guide to this cardiac imaging subspecialty. Including both technical and clinical aspects, it provides a foundation of essential knowledge common to practitioners from any background.This title covers radiation physics, biology and protection, and addresses all areas of imaging including the design and operation of the gamma camera (including solid-state cameras), single photon emission computed tomography (SPECT) acquisition and processing, and image interpretation and writing of reports. Stress testing and radiopharmaceuticals are explained in detail, as is the evidence-base underpinning myocardial perfusion scintigraphy. Newer radionuclide imaging techniques are well-covered (e.g. phosphate scintigraphy in cardiac amyloidosis), as is the expanding field of cardiac positron emission tomography (PET).Fully updated with coverage of new indications for gamma camera imaging, increased focus on attenuation correction and SPECT-CT and detail on the design use and clinical implications of solid-state gamma cameras throughout, this second edition of the essential text for nuclear cardiology trainees and practitioners is fully illustrated with colour plates to aid clinical practice. Presented in the bestselling Oxford Specialist Handbook format, Nuclear Cardiology provides core knowledge for those training in the subspecialty, whether at a basic or advanced level or from a medical or technical background, and is a key resource for those seeking to accredit in the subspecialty.

Radioisotope therapy is an internal form of radiation used to treat cancer; it may be administered orally or intravenously and represents the nearest treatment option to the ''magic bullet'', specifically targeting sites of disease whilst sparing surrounding normal tissues. Radioisotope therapy has an important role to play in modern medicine, particularly in the treatment of thyroid disease, neuroendocrine tumours, bone metastasis and non-Hodgkin''s lymphoma. It isfound in both the diagnostic setting and in therapy, but recently there has been a renaissance in the application of radioisotope unsealed sources in therapeutic indications. It is an active area of research, with the quest for new compounds that will be specific for therapeutic targets.This book is an essential, practical guide to the use of radioisotope therapy, and also includes the background and developmental biology which underpins its use. Individual tumours and diseases are explored, with specific focus given to radioisotope treatment options. The barriers to radioisotope therapy, such as ease of access, acquisition of radioisotopes, radiation protection regulations, and cost are also discussed.ABOUT THE SERIESRadiotherapy remains the major non-surgical treatment modality for the management of malignant disease, with over 50% of patients receiving treatment at some time during the management of their malignant disease. It is based on the application of the principles of applied physics, radiobiology, and tumour biology to clinical practice. Each volume in this series takes the reader through the basic principles of different types of radiotherapy, and then develops these by individual sites. Thisseries of practical handbooks are aimed at physicians both training and practising in radiotherapy, as well as medical physicists, dosimetrists, radiographers and senior nurses.

As functional imaging becomes increasingly important in radiology, practitioners in a wide range of disciplines need to understand more about the quantitive aspects of physiology and pathophysiology. In straightforward language, this book integrates the principles and mathematics of measurements with physiological systems to which the quantitive problems are applied. Although there is an emphasis on clinical management with radionuclides and quantitive procedures in nuclear medicine, this book has been written with all practitioners in mind and also therefore embraces techniques based on non-radioactive indicators, including contrast agents used in CT, MRI, and ultrasound. Starting from basic mathematics, the book describes the measurement of fundamental physiological variables, like transit time, clearance, and blood flow, and goes on to cover the perpheral circulation and microvascular solute transfer, the pharmacokinetics of agents routinely used in nuclear medicine, as well as scintillation detectors, data processing, and quantification. In separate chapters, measurements in the heart, lung, gastrointestinal tract, liver, blood, genitourinary tract, brain, and skeleton are discussed, and the book finishes with a chapter on questions and worked answers.

The European Society of Cardiology publications are key reference works authored and edited by leading international experts. Aligned with the ESC Core Curriculum, the ESC suite of publications are optimally placed for training and accreditation in cardiovascular medicine and related specialties.Our extensive line-up of publications is anchored by the groundbreaking ESC CardioMed: an online-only work comprised of nearly 70 sections, with over 1000 chapters, and authors from around the globe. Every publication is peer reviewed and supported by evidence-based research, reflects current ESC guidelines, the educational syllabus, task force reports, and the scientific statements that guide current clinical practice.Digital excellence at the heart of cardiology All ESC publications are available in multiple outputs, with an increased emphasis of online updates to meet the needs of todays user. Oxford University Press shares the ESC mission to reduce the burden of cardiovascular disease through this publishing partnership.

Part of the European Society of Cardiology portfolio of titles, the EACVI Handbook of Nuclear Cardiology serves as a user-friendly clinical guide to the field of nuclear cardiology. Covering all aspects of this ever-expanding area, it is an indispensable tool in the diagnosis and management of patients with heart failure (ischemic and non-ischemic), amyloid heart disease, endocarditis, myocarditis, and cardiac sarcoidosis.The handbook includes many images, tables, and bullet points that can be used daily in your busy practice to refresh your memory on various cardiac pathologies. The illustrations are derived from a typical clinical practice and the easy accessible format allows you as a reader to focus on the “typical findings” of various cardiac pathologies. Written by an international collection of experts this concise and practical handbook will appeal to students, trainees or advanced users; cardiologists, radiologists, cardiac surgeons or technicians, in their everyday practice.