Decoding the JAK-STAT Pathway

Emerging Insights and Clinical Applications Across Diseases

Häftad, Engelska, 2027

1 882 kr

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Beskrivning

Decoding the JAK-STAT Pathway: Emerging Insights and Clinical Applications Across Diseases offers a comprehensive exploration of one of the most vital molecular signaling pathways in human health and immune regulation. This reference addresses the critical need for an integrated resource that connects fundamental immunological mechanisms with translational and clinical applications, particularly in autoimmune, inflammatory, and infectious diseases. The book covers the pathway’s physiological roles in cytokine signaling, immune homeostasis, and cellular communication, as well as its dysregulation in conditions such as rheumatoid arthritis, inflammatory bowel disease, neuroinflammation, and viral infections. Its chapters feature contributions from global experts, detailing recent advances in targeted therapies, including JAK inhibitors, and their potential for personalized medicine. The content is organized to highlight disease-specific roles, therapeutic strategies, and emerging research directions, making it an essential resource for immunologists, biomedical scientists, clinicians, and pharmaceutical researchers seeking an authoritative, up-to-date guide to the molecular and clinical aspects of JAK-STAT signaling. By elucidating how this pathway influences immune responses and disease progression, the book facilitates a deeper understanding of immune regulation and offers insights into novel treatment approaches, ultimately supporting advancements in immunotherapy and precision medicine across diverse patient populations worldwide.

Integrates molecular immunology with translational and clinical insights on JAK-STAT signaling
Highlights the pathway’s central role in immune regulation and autoimmune diseases
Describes recent advances in targeted therapies for immune-mediated disorders
Provides a global perspective on immune-related research and therapeutic strategies
Serves as a comprehensive resource for immunologists, clinicians, and researchers

Produktinformation

Utgivningsdatum:2027-03-01
Mått:191 x 235 x undefined mm
Format:Häftad
Språk:Engelska
Antal sidor:300
Förlag:Elsevier Science
ISBN:9780443540813

Utforska kategorier

Sjukdomar och rubbningar inom Medicin
Onkologi inom Medicin

Mer om författaren

Dr. Meenakshi Dhanawat is an Associate Professor at the Amity Institute of Pharmacy, Amity University Haryana, with many years of experience in Pharmaceutical Sciences and Medicinal Chemistry. She completed her Master's degree at NIPER, Mohali, focusing on glycosylamino acids, and earned her Ph.D. from IIT-BHU, Varanasi, investigating CNS drug delivery targeting 5HT1A/2A receptors. Her research encompasses synthetic and heterocyclic chemistry, nanotechnology, drug delivery systems, prodrug design, complexation, polymer chemistry, and herbal drug extraction. Dr. Dhanawat has received notable international recognition, including a travel grant from the AAPS Drug Delivery and Development section for the 2010 National Biotechnology Conference in California, and international travel grants from DBT and DST, Government of India, for conferences in California and Munich. Her distinguished honors include the Rajiv Gandhi National Fellowship, affirming her sustained contributions to pharmaceutical research and academic excellence. Dr. Inderjeet Verma is a Professor and Head of Pharm.D at M.M. College of Pharmacy, with over 16 years of experience in pharmacology and drug development. His research spans clinical pharmacology, rheumatology, and experimental therapeutics, with a focus on autoimmune and inflammatory diseases. He has published extensively and holds a UK patent on a medical UV device. His work emphasizes translational research, molecular signaling pathways, and innovative drug therapies for autoimmune disorders. His expertise in pharmacodynamics and clinical pharmacology supports the development of targeted treatments such as JAK inhibitors and signaling pathways in disease management.

Innehållsförteckning

1. Role of JAK-STAT Signaling in Physiology: Immunity and Homeostasis2. JAK-STAT Targeted Therapy in Immunology: Advances and Prospects3. Unraveling the JAK-STAT in Rheumatoid Arthritis4. Innovations in JAK-STAT Targeted Medicine Development of Inflammatory Bowel Disease5. Role of the JAK-STAT Pathway in Dermatologic Diseases: Pathophysiology and Therapeutic Implications6. Exploring the Role of JAK/STAT Signaling in Osteoarthritis Progression7. The JAK-STAT Pathway as a Novel Antiviral Target: Mechanisms and Therapeutic Prospect8. Exploring the JAK/STAT Pathway in Metabolic Disorders: Obesity and Diabetes9. JAK Inhibitors for Respiratory Disorders10. Deciphering JAK/STAT Signaling Roles in Tumorigenesis and Therapeutic Targeting11. Neuroinflammation and Neurological Disorders: The Rescue of the JAK/STAT Signaling Cascade12. Pediatric Applications and Considerations of JAK Inhibition13. Exploring the Integration of JAK/STAT with Other Signaling Pathways in Health and Disease