In this issue of Clinics in Laboratory Medicine, guest editor Dr. Nicole A. Cipriani brings her considerable expertise to the topic of Endocrine Pathology. Top experts discuss common or complex problems in thyroid and parathyroid pathology, emerging molecular findings in endocrine neoplasms and syndromes, and new horizons for diagnosis and treatment of endocrine tumors. This issue address challenges that pathologists encounter in daily practice as well as introduces innovations in the interdisciplinary practice of medicine related to endocrine tumors.