Volatile Biomarkers

Cristina Davis is chair and professor of Mechanical and Aerospace Engineering at the University of California Davis, United States. Her research focuses on development of novel chemical and biological sensor systems and biomarker identification in agriculture and human/animal health monitoring. She has 12 issued patents and has coauthored over 100 peer-reviewed journal articles and book chapters. She is current chair-elect of IABR. Jonathan Beauchamp is manager of the Emissions Analytics and Diagnostics group at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising, Germany. He has been involved in academic and industrial breath research for the past 15 years and is currently principal investigator in several breath-related projects. He is an active member and current treasurer of the International Association of Breath Research (IABR).

"The book appropriately starts with a discussion of interpreting breath analyses, and readers quickly learn that the lack of standardization for specimen collection, patient preparation, or laboratory analytical methodology has greatly limited its applicability to assessing human health or disease…This book nicely summarizes the current state of the art of VOC detection and analysis for a variety of interesting applications." --Doody.com, November 2013"Volatile organic compounds are continuously generated by the human body and partially emitted in exhaled breath and through the skin, as well as other pathways…Medical, biological, chemical, and engineering specialists review developments in breath analysis since 2005, when the previous volume was completed." --Reference & Research Book News, October 2013

• A: Interpretation of Breath Analysis Data1. Mathematical and Statistical Approaches for Interpreting Biomarker Compounds in Exhaled Human Breath2. Issues and Challenges in Human Breath Research: Perspectives from Our ExperienceB: Real-Time Analysis of Exhaled Breath3. Physiological Modeling for Analysis of Exhaled BreathC: Physiological and Clinical Studies4. Recent SIFT-MS Studies of Volatile Compounds in Physiology, Medicine and Cell Biology5. The Analysis of Oral Air by Selected Ion Flow Tube Mass Spectrometry Using Indole and Methylindole as Examples6. Smokers Breath as Seen by Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry (PTR-TOF-MS)7. Exhaled Breath Analysis in Occupational Medicine8. Volatile Organic Compounds in Human Breath: Biogenic Origin and Point-of-Care AnalysisApproaches9. Breath Analysis in Critically Ill Patients—Potential and Limitations10. Analysis of Cancer Biomarkers in Exhaled Breath and Comparison with Sensory Indications by DogsD: Nitric Oxide, No, and Carbon Monoxide, Co11. Added Value with Extended NO Analysis12. Carbon Monoxide as an Exhaled Biomarker of Pulmonary Diseases13. Exhaled Nitric Oxide in Clinical Practice: Recent Advances and New ChallengesE: Clinical Breath Tests14. An Update on 13C-Breath Tests: The Transition to Acceptability into Clinical PracticeF: Development and Use Of Sensors15. Sensors for Exhaled Gas Analysis: An Analytical Review16. Arrays of Nanomaterial-Based Sensors for Breath Testing17. Smart Sensor Systems for Human Health Breath Monitoring Applications18. VOC Analysis by SIFT-MS, GC-MS, and Electronic Nose for Diagnosing and Monitoring DiseaseG: Exhaled Breath Condensate (Ebc) And Particulates19. Measurement of Biomarkers of Oxidative Stress and Airway Inflammation in Exhaled Breath Condensate: Methodology and Potential Applications in Patients with COPD and Healthy Smokers20. Particles in Exhaled Air—A Novel Method of Sampling Non-Volatiles in Exhaled AirH: Volatiles Of Microbial Origin: Urine, Stool and In Vitro Cultures21. Challenges in the Investigation of Volatile Disease Biomarkers in Urine22. Volatile Organic Compounds (VOCs) Found in Urine and Stool23. Volatile Organic Compounds (VOCs) Released by Pathogenic Microorganisms in vitro: Potential Breath Biomarkers for Early-Stage Diagnosis of DiseaseI: Urban Search and Rescue Operations24. Potential Applications of Volatile Organic Compounds in Safety and Security