Mark Hallett, MD, Senior Investigator at National Institute of Neurological Disorders and Stroke (NINDS), Chief of the Medical Neurology Branch and Chief of Human Motor Control Section; Editor-in-Chief of Clinical Neurophysiology; Associate Editor of Brain. Werner Poewe, Chairman of the Department of Neurology at Medical University of Innsbruck; Editorial board member of Movement Disorder, Journal of Neurology, Journal of Neural Transmission, and Aktuelle Neurologie.

"This book can be strongly recommended and is an asset to libraries of both movement disorder specialists and general neurologists. Its logical structure, linking therapy with underlying pathophysiology, means that it will remain a useful reference even as new therapies inevitably emerge." (The Lancet Neurology, July 2009)

• Preface ixContributors xiPart I Parkinson’s Disease and Parkinsonism1 The Etiopathogenesis of Parkinson’s Disease: Basic Mechanisms of Neurodegeneration 3C. Warren Olanow and Kevin McNaught2 Physiology of Parkinson’s Disease 25Shlomo Elias, Zvi Israel and Hagai Bergman3 Pharmacology of Parkinson’s Disease 37Jonathan M. Brotchie4 The Treatment of Early Parkinson’s Disease 49Olivier Rascol and Regina Katzenschlager5 Treatment of Motor Complications in Advanced Parkinson’s Disease 71Susan H. Fox and Anthony E. Lang6 Managing the Non-Motor Symptoms of Parkinson’s Disease 91Werner Poewe and Klaus Seppi7 Surgery for Parkinson’s Disease 121Jens Volkmann8 Future Cell- and Gene-Based Therapies for Parkinson’s Disease 145Tomas Björklund, Asuka Morizane, Deniz Kirik and Patrik Brundin9 Parkinson-Plus Disorders 157Martin Köllensperger and Gregor K. WenningPart II Tremor Disorders10 Essential Tremor 179Rodger J. Elble11 Other Tremor Disorders 193Günther DeuschlPart III Dystonia, Cramps, and Spasms12 Pathophysiology of Dystonia 205Mark Hallett13 General Management Approach to Dystonia 217Cynthia L. Comella14 Botulinum Toxin for Treatment of Dystonia 227Dirk Dressler15 Surgical Treatments of Dystonia 241Christopher Kenney and Joseph Jankovic16 Wilson’s Disease 251George J. Brewer17 Cramps and Spasms 263Christine D. Esper, Pratibha G. Aia, Leslie J. Cloud and Stewart A. Factor18 Stiff Person Syndrome 283Philip D. Thompson and Hans-Michael MeinckPart IV Chorea, Tics and other Movement Disorders19 Huntington’s Disease 295Kevin M. Biglan and Ira Shoulson20 Chorea 317Francisco Cardoso21 Treatment of Tics and Tourette Syndrome 331Harvey S. Singer and Erika L.F. Hedderick22 Therapeutics of Paroxysmal Dyskinesias 345Shyamal H. Mehta and Kapil D. Sethi23 Treatment of Miscellaneous Disorders 353Marie Vidailhet, Emmanuel Roze and David Grabli24 Myoclonus 363Shu-Ching Hu, Steven J. Frucht and Hiroshi ShibasakiPart V Drug-induced Movement Disorders25 Neuroleptic-Induced Movement Disorders 373S. Elizabeth Zauber and Christopher G. Goetz26 Other Drug-Induced Dyskinesias 389Oscar S. GershanikPart VI Ataxia and Disorders of Gait and Balance27 Ataxia 407Thomas Klockgether28 Treatment of Gait and Balance Disorders 417Bastiaan R. Bloem, Alexander C. Geurts, S. Hassin-Baer and Nir GiladiPart VII Restless Legs Syndrome29 The Restless Legs Syndrome 447Richard P. Allen and Birgit H€oglPart VIII Pediatric Movement Disorders30 Pediatric Movement Disorders 471Jonathan W. MinkPart IX Psychogenic Movement Disorders31 Psychogenic Movement Disorders 479Elizabeth Peckham and Mark HallettIndex 489

Mark Hallett, MD, Senior Investigator at National Institute of Neurological Disorders and Stroke (NINDS), Chief of the Medical Neurology Branch and Chief of Human Motor Control Section; Editor-in-Chief of Clinical Neurophysiology; Associate Editor of Brain. Werner Poewe, Chairman of the Department of Neurology at Medical University of Innsbruck; Editorial board member of Movement Disorder, Journal of Neurology, Journal of Neural Transmission, and Aktuelle Neurologie.

"This book can be strongly recommended and is an asset to libraries of both movement disorder specialists and general neurologists. Its logical structure, linking therapy with underlying pathophysiology, means that it will remain a useful reference even as new therapies inevitably emerge." (The Lancet Neurology, July 2009)

• Preface ixContributors xiPart I Parkinson’s Disease and Parkinsonism1 The Etiopathogenesis of Parkinson’s Disease: Basic Mechanisms of Neurodegeneration 3C. Warren Olanow and Kevin McNaught2 Physiology of Parkinson’s Disease 25Shlomo Elias, Zvi Israel and Hagai Bergman3 Pharmacology of Parkinson’s Disease 37Jonathan M. Brotchie4 The Treatment of Early Parkinson’s Disease 49Olivier Rascol and Regina Katzenschlager5 Treatment of Motor Complications in Advanced Parkinson’s Disease 71Susan H. Fox and Anthony E. Lang6 Managing the Non-Motor Symptoms of Parkinson’s Disease 91Werner Poewe and Klaus Seppi7 Surgery for Parkinson’s Disease 121Jens Volkmann8 Future Cell- and Gene-Based Therapies for Parkinson’s Disease 145Tomas Björklund, Asuka Morizane, Deniz Kirik and Patrik Brundin9 Parkinson-Plus Disorders 157Martin Köllensperger and Gregor K. WenningPart II Tremor Disorders10 Essential Tremor 179Rodger J. Elble11 Other Tremor Disorders 193Günther DeuschlPart III Dystonia, Cramps, and Spasms12 Pathophysiology of Dystonia 205Mark Hallett13 General Management Approach to Dystonia 217Cynthia L. Comella14 Botulinum Toxin for Treatment of Dystonia 227Dirk Dressler15 Surgical Treatments of Dystonia 241Christopher Kenney and Joseph Jankovic16 Wilson’s Disease 251George J. Brewer17 Cramps and Spasms 263Christine D. Esper, Pratibha G. Aia, Leslie J. Cloud and Stewart A. Factor18 Stiff Person Syndrome 283Philip D. Thompson and Hans-Michael MeinckPart IV Chorea, Tics and other Movement Disorders19 Huntington’s Disease 295Kevin M. Biglan and Ira Shoulson20 Chorea 317Francisco Cardoso21 Treatment of Tics and Tourette Syndrome 331Harvey S. Singer and Erika L.F. Hedderick22 Therapeutics of Paroxysmal Dyskinesias 345Shyamal H. Mehta and Kapil D. Sethi23 Treatment of Miscellaneous Disorders 353Marie Vidailhet, Emmanuel Roze and David Grabli24 Myoclonus 363Shu-Ching Hu, Steven J. Frucht and Hiroshi ShibasakiPart V Drug-induced Movement Disorders25 Neuroleptic-Induced Movement Disorders 373S. Elizabeth Zauber and Christopher G. Goetz26 Other Drug-Induced Dyskinesias 389Oscar S. GershanikPart VI Ataxia and Disorders of Gait and Balance27 Ataxia 407Thomas Klockgether28 Treatment of Gait and Balance Disorders 417Bastiaan R. Bloem, Alexander C. Geurts, S. Hassin-Baer and Nir GiladiPart VII Restless Legs Syndrome29 The Restless Legs Syndrome 447Richard P. Allen and Birgit H€oglPart VIII Pediatric Movement Disorders30 Pediatric Movement Disorders 471Jonathan W. MinkPart IX Psychogenic Movement Disorders31 Psychogenic Movement Disorders 479Elizabeth Peckham and Mark HallettIndex 489