Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration.Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, Dec 2007).

"For those wishing to gain an insight the potential power of toxicogenomics in toxicity assessment Toxicogenomics: A Powerful Tool for Toxicity Assessment will be if interest." (BTS Newsletter, Summer 2009)

• Preface xiList of Contributors xiiiAcknowledgments xixSection 1 Design, Analysis and Interpretation Of Toxicogenomics1 Mechanistic Toxicogenomics: Design and Analysis of Microarray Experiments 3Kirstin Meyer, Susanne Schwenke and Johanna M. Beekman2 A New Approach to Analysis and Interpretation of Toxicogenomic Gene Expression Data and its Importance in Examining Biological Responses to Low, Environmentally Relevant Doses of Toxicants 27Julie A. Gosse, Thomas H. Hampton, Jennifer C. Davey and Joshua W. Hamilton3 Principles of Data Mining in Toxicogenomics 59Yoko Hirabayashi and Tohru Inoue Copyrighted Material4 Design Issues in Toxicogenomics: The Application of Genomic Technologies for Mechanistic and Predictive Research 87Woong-Yang Park, Lian Li and Daehee Kang5 Sources of Variability in Toxicogenomic Assays 101Karol Thompson, P. Scott Pine and Barry Rosenzweig6 Key Aspects of Toxicogenomic Data Analysis and Interpretation as a Safety Assessment Tool to Identify and Understand Drug-Induced Toxicity 111Antoaneta Vladimirova and Brigitte GanterSection 2 Applications of Toxicogenomics7 Toxicogenomics as a Tool to Assess Immunotoxicity 129Kirsten A. Baken, Janine Ezendam, Jeroen L.A. Pennings, Rob J. Vandebriel and Henk van Loveren8 Toxicogenomics and Ecotoxicogenomics: Studying Chemical Effects and Basic Biology in Vertebrates and Invertebrates 143Taisen Iguchi, Hajime Watanabe and Yoshinao Katsu9 Gene Expression Profiling of Transplacental Arsenic Carcinogenesis in Mice 159Jie Liu, Bhalchandra A. Diwan, Raymond Tennant and Michael P. Waalkes10 Characterization of Estrogen-active Compounds and Estrogenic Signaling by Global Gene Expression Profiling In Vitro 175Stephanie Simon, Kathleen Boehme, Susanne U. Schmidt and Stefan O. Mueller11 Escherichia coli Stress Response as a Tool for Detection of Toxicity 199Arindam Mitra, Nabarun Chakraborti and Suman Mukhopadhyay12 Toxicogenomics In Vitro: A Powerful Tool for Screening Hepatotoxic Potential of Food-related Products 211Saura C. Sahu13 Toxicogenomics Approach to Drug-induced Phospholipidosis 225Hiroshi Sawada14 Use of Toxicogenomics as an Early Predictive Tool for Hepatotoxicity 235Laura Suter15 Nutrigenomics: The Application of Genomics Signatures in Nutrition-related Research 253Elisavet T. Gatzidou and Stamatios E. Theocharis16 Application of Toxicogenomics in Drug Discovery 269Michael J. Liguori, Amy C. Ditewig and Jeffrey F. WaringSection 3 Toxicogenomics and Risk Assessment17 Natural Products from Medicinal Plants and Risk Assessment 289Leila Chekir-Ghedira18 The Development of a Metabonomic-based Drug Safety Testing Paradigm 309Muireann Coen, Elaine Holmes, Jeremy K. Nicholson and John C. Lindon19 Potential Uses of Toxicogenomic Biomarkers in Occupational Health and Risk Assessment 345Paul A. NonySection 4 Toxicogenomics for Regulatory Use20 Toxicogenomics: A Regulatory Perspective 355Daniel A. Casciano21 Toxicogenomics for Regulatory Use: The View from the Bench 365P. Ancian, S. Leuillet, S. Arthaud, J.J. Legrand and R. Forster22 Perspectives on Toxicogenomics Activities at the US Environmental Protection Agency 377Karen Hamernik, Kenneth Haymes, Susan Hester and J. Thomas McClintockIndex 397

Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration.Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, Dec 2007).

"For those wishing to gain an insight the potential power of toxicogenomics in toxicity assessment Toxicogenomics: A Powerful Tool for Toxicity Assessment will be if interest." (BTS Newsletter, Summer 2009)

• Preface xiList of Contributors xiiiAcknowledgments xixSection 1 Design, Analysis and Interpretation Of Toxicogenomics1 Mechanistic Toxicogenomics: Design and Analysis of Microarray Experiments 3Kirstin Meyer, Susanne Schwenke and Johanna M. Beekman2 A New Approach to Analysis and Interpretation of Toxicogenomic Gene Expression Data and its Importance in Examining Biological Responses to Low, Environmentally Relevant Doses of Toxicants 27Julie A. Gosse, Thomas H. Hampton, Jennifer C. Davey and Joshua W. Hamilton3 Principles of Data Mining in Toxicogenomics 59Yoko Hirabayashi and Tohru Inoue Copyrighted Material4 Design Issues in Toxicogenomics: The Application of Genomic Technologies for Mechanistic and Predictive Research 87Woong-Yang Park, Lian Li and Daehee Kang5 Sources of Variability in Toxicogenomic Assays 101Karol Thompson, P. Scott Pine and Barry Rosenzweig6 Key Aspects of Toxicogenomic Data Analysis and Interpretation as a Safety Assessment Tool to Identify and Understand Drug-Induced Toxicity 111Antoaneta Vladimirova and Brigitte GanterSection 2 Applications of Toxicogenomics7 Toxicogenomics as a Tool to Assess Immunotoxicity 129Kirsten A. Baken, Janine Ezendam, Jeroen L.A. Pennings, Rob J. Vandebriel and Henk van Loveren8 Toxicogenomics and Ecotoxicogenomics: Studying Chemical Effects and Basic Biology in Vertebrates and Invertebrates 143Taisen Iguchi, Hajime Watanabe and Yoshinao Katsu9 Gene Expression Profiling of Transplacental Arsenic Carcinogenesis in Mice 159Jie Liu, Bhalchandra A. Diwan, Raymond Tennant and Michael P. Waalkes10 Characterization of Estrogen-active Compounds and Estrogenic Signaling by Global Gene Expression Profiling In Vitro 175Stephanie Simon, Kathleen Boehme, Susanne U. Schmidt and Stefan O. Mueller11 Escherichia coli Stress Response as a Tool for Detection of Toxicity 199Arindam Mitra, Nabarun Chakraborti and Suman Mukhopadhyay12 Toxicogenomics In Vitro: A Powerful Tool for Screening Hepatotoxic Potential of Food-related Products 211Saura C. Sahu13 Toxicogenomics Approach to Drug-induced Phospholipidosis 225Hiroshi Sawada14 Use of Toxicogenomics as an Early Predictive Tool for Hepatotoxicity 235Laura Suter15 Nutrigenomics: The Application of Genomics Signatures in Nutrition-related Research 253Elisavet T. Gatzidou and Stamatios E. Theocharis16 Application of Toxicogenomics in Drug Discovery 269Michael J. Liguori, Amy C. Ditewig and Jeffrey F. WaringSection 3 Toxicogenomics and Risk Assessment17 Natural Products from Medicinal Plants and Risk Assessment 289Leila Chekir-Ghedira18 The Development of a Metabonomic-based Drug Safety Testing Paradigm 309Muireann Coen, Elaine Holmes, Jeremy K. Nicholson and John C. Lindon19 Potential Uses of Toxicogenomic Biomarkers in Occupational Health and Risk Assessment 345Paul A. NonySection 4 Toxicogenomics for Regulatory Use20 Toxicogenomics: A Regulatory Perspective 355Daniel A. Casciano21 Toxicogenomics for Regulatory Use: The View from the Bench 365P. Ancian, S. Leuillet, S. Arthaud, J.J. Legrand and R. Forster22 Perspectives on Toxicogenomics Activities at the US Environmental Protection Agency 377Karen Hamernik, Kenneth Haymes, Susan Hester and J. Thomas McClintockIndex 397

Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration.Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, Dec 2007).

"For those wishing to gain an insight the potential power of toxicogenomics in toxicity assessment Toxicogenomics: A Powerful Tool for Toxicity Assessment will be if interest." (BTS Newsletter, Summer 2009)

• Preface xiList of Contributors xiiiAcknowledgments xixSection 1 Design, Analysis and Interpretation Of Toxicogenomics1 Mechanistic Toxicogenomics: Design and Analysis of Microarray Experiments 3Kirstin Meyer, Susanne Schwenke and Johanna M. Beekman2 A New Approach to Analysis and Interpretation of Toxicogenomic Gene Expression Data and its Importance in Examining Biological Responses to Low, Environmentally Relevant Doses of Toxicants 27Julie A. Gosse, Thomas H. Hampton, Jennifer C. Davey and Joshua W. Hamilton3 Principles of Data Mining in Toxicogenomics 59Yoko Hirabayashi and Tohru Inoue Copyrighted Material4 Design Issues in Toxicogenomics: The Application of Genomic Technologies for Mechanistic and Predictive Research 87Woong-Yang Park, Lian Li and Daehee Kang5 Sources of Variability in Toxicogenomic Assays 101Karol Thompson, P. Scott Pine and Barry Rosenzweig6 Key Aspects of Toxicogenomic Data Analysis and Interpretation as a Safety Assessment Tool to Identify and Understand Drug-Induced Toxicity 111Antoaneta Vladimirova and Brigitte GanterSection 2 Applications of Toxicogenomics7 Toxicogenomics as a Tool to Assess Immunotoxicity 129Kirsten A. Baken, Janine Ezendam, Jeroen L.A. Pennings, Rob J. Vandebriel and Henk van Loveren8 Toxicogenomics and Ecotoxicogenomics: Studying Chemical Effects and Basic Biology in Vertebrates and Invertebrates 143Taisen Iguchi, Hajime Watanabe and Yoshinao Katsu9 Gene Expression Profiling of Transplacental Arsenic Carcinogenesis in Mice 159Jie Liu, Bhalchandra A. Diwan, Raymond Tennant and Michael P. Waalkes10 Characterization of Estrogen-active Compounds and Estrogenic Signaling by Global Gene Expression Profiling In Vitro 175Stephanie Simon, Kathleen Boehme, Susanne U. Schmidt and Stefan O. Mueller11 Escherichia coli Stress Response as a Tool for Detection of Toxicity 199Arindam Mitra, Nabarun Chakraborti and Suman Mukhopadhyay12 Toxicogenomics In Vitro: A Powerful Tool for Screening Hepatotoxic Potential of Food-related Products 211Saura C. Sahu13 Toxicogenomics Approach to Drug-induced Phospholipidosis 225Hiroshi Sawada14 Use of Toxicogenomics as an Early Predictive Tool for Hepatotoxicity 235Laura Suter15 Nutrigenomics: The Application of Genomics Signatures in Nutrition-related Research 253Elisavet T. Gatzidou and Stamatios E. Theocharis16 Application of Toxicogenomics in Drug Discovery 269Michael J. Liguori, Amy C. Ditewig and Jeffrey F. WaringSection 3 Toxicogenomics and Risk Assessment17 Natural Products from Medicinal Plants and Risk Assessment 289Leila Chekir-Ghedira18 The Development of a Metabonomic-based Drug Safety Testing Paradigm 309Muireann Coen, Elaine Holmes, Jeremy K. Nicholson and John C. Lindon19 Potential Uses of Toxicogenomic Biomarkers in Occupational Health and Risk Assessment 345Paul A. NonySection 4 Toxicogenomics for Regulatory Use20 Toxicogenomics: A Regulatory Perspective 355Daniel A. Casciano21 Toxicogenomics for Regulatory Use: The View from the Bench 365P. Ancian, S. Leuillet, S. Arthaud, J.J. Legrand and R. Forster22 Perspectives on Toxicogenomics Activities at the US Environmental Protection Agency 377Karen Hamernik, Kenneth Haymes, Susan Hester and J. Thomas McClintockIndex 397