Nicusor Iftimia is leader of the Advanced Microscopy and Image Guided Interventions Group at Physical Sciences, Inc. in Andover, Massachusetts. He has been awarded several NIH and DoD grants to conduct cutting-edge research in biomedical optics imaging for cancer diagnosis and therapy guidance. He has published over forty peer-reviewed journal papers, is the author of several book chapters, and a co-inventor of more than ten patents. William R. Brugge is Director of the Gastrointestinal Endoscopy Unit at the Massachusetts General Hospital and Professor of Medicine at Harvard Medical School. Dr. Brugge pioneered the use of endoscopic ultrasound imaging¿in the diagnosis and staging of gastrointestinal malignancies, particularly early malignancies of the pancreas.Daniel X. Hammer is leader of the Biomedical Imaging Group at Physical Sciences, Inc. in Andover, Massachusetts. He specializes in the development of innovative biomedical optical instruments, conducting international award-winning research in the area of ophthalmology and adaptive optics. He has published more than forty peer-reviewed journal papers and is a co-inventor of more than ten patents.

• Contributors. Preface.1 Introduction to Optical Imaging in Clinical Medicine (Nicusor Iftimia, Daniel X. Hammer, and William R. Brugge).2 Traditional Imaging Modalities in Clinical Medicine (Ileana Iftimia and Herbert Mower).3 Current Imaging Approaches and Further Imaging Needs in Clinical Medicine: A Clinician’s Perspective (Gadi Wollstein and Joel S. Schuman, Cetin Karaca, Sevdenur Cizginer, and William R. Brugge, Ik-Kyung Jang and Jin-Man Cho, Peter K. Dempsey).4 Advances in Retinal Imaging (Daniel X. Hammer).5 Confocal Microscopy of Skin Cancers (Juliana Casagrande Tavoloni Braga, Itay Klaz, Alon Scope, Daniel Gareau, Milind Rajadhyaksha, and Ashfaq A. Marghoob).6 High-Resolution Optical Coherence Tomography Imaging in Gastroenterology (Melissa J. Suter, Brett E. Bouma, and Guillermo J. Tearney).7 High-Resolution Confocal Endomicroscopy for Gastrointestinal Cancer Detection (Jonathan T. C. Liu, Jonathan W. Hardy, and Christopher H. Contag).8 High-Resolution Optical Imaging in Interventional Cardiology (Thomas J. Kiernan, Bryan P. Yan, Kyoichi Mizuno, and Ik-Kyung Jang).9 Fluorescence Lifetime Spectroscopy in Cardio and Neuroimaging (Laura Marcu, Javier A. Jo, and Pramod Butte).10 Advanced Optical Methods for Functional Brain Imaging: Time-Domain Functional Near-Infrared Spectroscopy (Alessandro Torricelli, Davide Contini, Lorenzo Spinelli, Matteo Caffini, Antonio Pifferi, and Rinaldo Cubeddu).11 Advances in Optical Mammography (Xavier Intes and Fred S. Azar).12 Photoacoustic Tomography (Huabei Jiang and Zhen Yuan).13 Optical Imaging and Measurement of Angiogenesis (Brian S. Sorg).14 High-Resolution Phase-Contrast Optical Coherence Tomography for Functional Biomedical Imaging (Taner Akkin and Digant P. Davé).15 Polarization Imaging (Mircea Mujat).16 Nanotechnology Approaches to Contrast Enhancement in Optical Imaging and Disease-Targeted Therapy (Nicusor Iftimia, Lara Milane, Amy Oldenburg, and Mansoor Amiji).17 Molecular Probes for Optical Contrast Enhancement of Gastrointestinal Cancers (Jonathan W. Hardy, Anson W. Lowe, Christopher H. Contag, and Jonathan T. C. Liu).Index.