GUOAN LUO is Professor in the Institute of Biomedicine and Director of the Modern Research Center for Traditional Chinese Medicine at Tsinghua University in Beijing. Professor Luo is dedicated to the application of systems biology to study and advance TCM. He has published more than 680 peer-reviewed papers and applied for thirty-one patents. Among the many honors he has received for his research achievements are two National Scientific and Technological Advancement Prizes. YIMING WANG is Professor at Tsinghua University.QIONGLIN LIANG is Associate Professor at Tsinghua University.QINGFEI LIU is Assistant Professor at Tsinghua University.

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• Foreword ixPreface xiiiAbbreviations xvii1 Introduction of Systems Biology in Traditional Chinese Medicine (tcm) 11.1 Characteristics and Compatibility Principles of Traditional Chinese Medicine (TCM) 11.2 Key Scientific Issues in TCM Modernization 91.3 Development of Systems Biology 161.4 Chemomics Integrated Systems Biology 191.5 Research Strategy and Prospective of Systems Biology in Tcm 25References 342 Chemomics of Traditional Chinese Medicine 382.1 Characteristics and Research Difficulties in TCM 392.2 Background of TCM Chemomics’ Proposal and Development 452.3 Chemomics 522.4 Chemomics and the Research of Formulas 58References 633 Technological Platform of Tcm Chemomics 663.1 Acquisition Methods and Techniques for TCM Chemomics 663.2 Characterization Techniques of Chemome-TCM Fingerprinting 733.3 Information Processing for the Study of TCM Chemomics 1073.4 Development of an Intelligent Quality Control System in the Process of Chinese Medicine Production 119References 1274 Pharmacokinetic Investigation on Tcm Formulas Based on Global Systems Biology 1314.1 Pharmacokinetic Characteristics of TCM Formulas 1314.2 Methodology of Pharmacokinetics of TCM Formulas 1334.3 Application of PK-PD Model in the Toxicological Research of Liushen Pills (LSP) 1384.4 Prospect 143References 1445 Application of Genomics in the Research of Tcm 1465.1 Genomics and TCM System Research 1465.2 Prospect of Genomics in TCM Research 1485.3 Cases of the Application of Genomics in TCM Research 148References 1686 Proteomics Study of Tcm 1716.1 Proteomics in TCM Research 1716.2 A Case Study of Proteomics in TCM 1746.3 The Application of High Content Screening in TCM Research 1826.4 Limitations and Prospect of TCM Proteomics 186References 1877 Application of Metabonomics in Research on Tcm 1917.1 Current Research Situation of Metabonomics 1917.2 Integration of Quantitative Metabonomics Platform Technology (qmpt) 1917.3 Application of Metabonomics in the Field of Medicine 1947.4 Examples of Metabonomic Research on TCM 198References 2068 Application of Chemometrics and Bioinformatics in Tcm Research 2108.1 Introduction of Chemometrics 2108.2 Chemometric Techniques and Their Applications in TCM Research 2118.3 Introduction of Bioinformatics 2168.4 Bioinformatics Techniques and Their Applications in the Research of TCM 2198.5 Conclusions 222References 2249 Study of Integrated Biomarker System of Diabetic Nephropathy 2289.1 Introduction of Diabetic Nephropathy 2289.2 Mogensen Staging and TCM Typing of DN 2349.3 The Metabonomics Study of DN 2449.4 Condition of Metabolism after Treatment with TangShen Formula (TSF) 2789.5 Genomics Study of Diabetic Neuropathy 2869.6 The Integrated Biomarker System of DN 3019.7 Conclusions 311References 31210 Chemomics Research on the Tcm Formula of The Qingkailing Injection 31710.1 Chemomics Research of Qingkailing Injection 31810.2 Pharmacodynamic Evaluation of Qingkailing Injection 33010.3 Research on the Qingkailing Derived Formula 33510.4 Conclusions 368References 36911 Integrated Global Systems Biology for the Research and Development of Chinese MedicineShuanglong Formula 37111.1 Brief Introduction to the Shuanglong Formula 37111.2 Chemomics Study of the Shuanglong Formula 37411.3 Pharmacodynamic Evaluation of SLF Effective Ingredients 38411.4 Systems Biology Study of the Mechanism of Directed Differentiation of Stem Cells Induced by NSLF6 40211.5 Anti-Myocardial Infarction Effect of NSLF6 42611.6 Conclusions 429References 43012 Demonstrative Research on the Safety Evaluation of Liushen Pills 43712.1 Introduction 43712.2 Toxicity Study of Chansu 43812.3 Chemomics Study of LSP 44612.4 Assessment of Effectiveness and Safety of LSP 45712.5 In Vivo Distribution and Metabonomics of LSP and Xionghuang 46212.6 Metabonomic Research of LSP 46712.7 Conclusions 477References 478Index 481

GUOAN LUO is Professor in the Institute of Biomedicine and Director of the Modern Research Center for Traditional Chinese Medicine at Tsinghua University in Beijing. Professor Luo is dedicated to the application of systems biology to study and advance TCM. He has published more than 680 peer-reviewed papers and applied for thirty-one patents. Among the many honors he has received for his research achievements are two National Scientific and Technological Advancement Prizes. YIMING WANG is Professor at Tsinghua University.QIONGLIN LIANG is Associate Professor at Tsinghua University.QINGFEI LIU is Assistant Professor at Tsinghua University.

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• Foreword ixPreface xiiiAbbreviations xvii1 Introduction of Systems Biology in Traditional Chinese Medicine (tcm) 11.1 Characteristics and Compatibility Principles of Traditional Chinese Medicine (TCM) 11.2 Key Scientific Issues in TCM Modernization 91.3 Development of Systems Biology 161.4 Chemomics Integrated Systems Biology 191.5 Research Strategy and Prospective of Systems Biology in Tcm 25References 342 Chemomics of Traditional Chinese Medicine 382.1 Characteristics and Research Difficulties in TCM 392.2 Background of TCM Chemomics’ Proposal and Development 452.3 Chemomics 522.4 Chemomics and the Research of Formulas 58References 633 Technological Platform of Tcm Chemomics 663.1 Acquisition Methods and Techniques for TCM Chemomics 663.2 Characterization Techniques of Chemome-TCM Fingerprinting 733.3 Information Processing for the Study of TCM Chemomics 1073.4 Development of an Intelligent Quality Control System in the Process of Chinese Medicine Production 119References 1274 Pharmacokinetic Investigation on Tcm Formulas Based on Global Systems Biology 1314.1 Pharmacokinetic Characteristics of TCM Formulas 1314.2 Methodology of Pharmacokinetics of TCM Formulas 1334.3 Application of PK-PD Model in the Toxicological Research of Liushen Pills (LSP) 1384.4 Prospect 143References 1445 Application of Genomics in the Research of Tcm 1465.1 Genomics and TCM System Research 1465.2 Prospect of Genomics in TCM Research 1485.3 Cases of the Application of Genomics in TCM Research 148References 1686 Proteomics Study of Tcm 1716.1 Proteomics in TCM Research 1716.2 A Case Study of Proteomics in TCM 1746.3 The Application of High Content Screening in TCM Research 1826.4 Limitations and Prospect of TCM Proteomics 186References 1877 Application of Metabonomics in Research on Tcm 1917.1 Current Research Situation of Metabonomics 1917.2 Integration of Quantitative Metabonomics Platform Technology (qmpt) 1917.3 Application of Metabonomics in the Field of Medicine 1947.4 Examples of Metabonomic Research on TCM 198References 2068 Application of Chemometrics and Bioinformatics in Tcm Research 2108.1 Introduction of Chemometrics 2108.2 Chemometric Techniques and Their Applications in TCM Research 2118.3 Introduction of Bioinformatics 2168.4 Bioinformatics Techniques and Their Applications in the Research of TCM 2198.5 Conclusions 222References 2249 Study of Integrated Biomarker System of Diabetic Nephropathy 2289.1 Introduction of Diabetic Nephropathy 2289.2 Mogensen Staging and TCM Typing of DN 2349.3 The Metabonomics Study of DN 2449.4 Condition of Metabolism after Treatment with TangShen Formula (TSF) 2789.5 Genomics Study of Diabetic Neuropathy 2869.6 The Integrated Biomarker System of DN 3019.7 Conclusions 311References 31210 Chemomics Research on the Tcm Formula of The Qingkailing Injection 31710.1 Chemomics Research of Qingkailing Injection 31810.2 Pharmacodynamic Evaluation of Qingkailing Injection 33010.3 Research on the Qingkailing Derived Formula 33510.4 Conclusions 368References 36911 Integrated Global Systems Biology for the Research and Development of Chinese MedicineShuanglong Formula 37111.1 Brief Introduction to the Shuanglong Formula 37111.2 Chemomics Study of the Shuanglong Formula 37411.3 Pharmacodynamic Evaluation of SLF Effective Ingredients 38411.4 Systems Biology Study of the Mechanism of Directed Differentiation of Stem Cells Induced by NSLF6 40211.5 Anti-Myocardial Infarction Effect of NSLF6 42611.6 Conclusions 429References 43012 Demonstrative Research on the Safety Evaluation of Liushen Pills 43712.1 Introduction 43712.2 Toxicity Study of Chansu 43812.3 Chemomics Study of LSP 44612.4 Assessment of Effectiveness and Safety of LSP 45712.5 In Vivo Distribution and Metabonomics of LSP and Xionghuang 46212.6 Metabonomic Research of LSP 46712.7 Conclusions 477References 478Index 481